Semantic-Episodic Memory Interactions in Semantic Dementia: Implications for Retrograde Memory Function

Snowden, Julie S.; Griffiths, Helen; Neary, David

doi:10.1080/026432996381674

Cited by 175 publications

(124 citation statements)

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“…Some fMRI work suggests that the hippocampus contributes to semantic memory, although the precise role of the hippocampus is debated (Kounios et al, 2003;Moscovitch et al, 2005;Nadel & Moscovitch, 1997;Ryan et al, 2000;Squire & Alvarez, 1995). Other work indicates, however, that patients with semantic dementia have difficulty learning and retaining meaningful information despite relatively intact episodic memory (Graham, Patterson, Pratt, & Hodges, 1999;Snowden, Griffiths, & Neary, 1996). The findings of the present study can be contrasted instructively with observations of lexical acquisition and hippocampal functioning in semantic dementia patients.…”

Section: Difficulty Acquiring the Meaning Of A New Word In Adcontrasting

confidence: 55%

Verb acquisition and representation in Alzheimer's disease

et al. 2007

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We examined the implicit acquisition and mental representation of a novel verb in patients with probable Alzheimer's disease (AD). Patients were exposed to the new verb in a naturalistic manner as part of a simple picture story. We probed grammatical, semantic and thematic matrix knowledge of the verb soon after presentation and again one week later. We found partial verb acquisition that was retained over one week. AD patients did not differ from controls in their acquisition and retention of a new verb's major grammatical subcategory, although they acquired little of its semantic properties and displayed minimal acquisition of the new word's thematic matrix. Moreover, AD patients appeared to maintain their acquired grammatical knowledge over one week. We discuss the implications of these findings from several perspectives, including the modularity of the language processing system, the relationship between episodic memory and semantic memory, and the role of the preserved implicit memory system in AD patients' partially successful lexical acquisition.

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Section: Difficulty Acquiring the Meaning Of A New Word In Adcontrasting

confidence: 55%

Verb acquisition and representation in Alzheimer's disease

et al. 2007

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“…A particular group in whom there may be disproportionate semantic memory loss is patients with semantic dementia, usually resulting from left temporal lobe atrophy. However, the interpretation of their remote memory loss is controversial: some studies report preservation for`recent' but not distant autobiographical memories (Snowden et al 1996;Graham & Hodges 1997), whereas others ¢nd a more uniform loss, largely secondary to their semantic memory de¢cit (Moss et al 2000).…”

Section: Dissociations Within Ra (A) Autobiographical Versus Semanticmentioning

confidence: 99%

“…A ¢fth argument is that there is at least some evidence that patients with lesions con¢ned to the diencephalic or medial temporal structures have an RA which may extend back 2^3 years but no further (Milner 1966;Zola-Morgan et al 1986;Dusoir et al 1990;Gra¡-Radford et al 1990;Snowden et al 1996;Graham & Hodges 1997;Guinan et al 1998). As will be discussed below (½ 5), cortical damage seems to be required for a more extensive RA, going back years or decades as is seen in (for example) the Korsako¡ syndrome, herpes encephalitis, or Alzheimer dementia (e.g.…”

Section: (C) Brief Versus Extensive Episodic Ramentioning

confidence: 99%

The loss of episodic memories in retrograde amnesia: single–case and group studies

Kopelman

Kapur

2001

Phil. Trans. R. Soc. Lond. B

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Retrograde amnesia in neurological disorders is a perplexing and fascinating research topic. The severity of retrograde amnesia is not well correlated with that of anterograde amnesia, and there can be disproportionate impairments of either. Within retrograde amnesia, there are various dissociations which have been claimedöfor example, between the more autobiographical (episodic) and more semantic components of memory. However, the associations of di¡erent types of retrograde amnesia are also important, and clari¢cation of these issues is confounded by the fact that retrograde amnesia seems to be particularly vulnerable to psychogenic factors. Large frontal and temporal lobe lesions have been postulated as critical in producing retrograde amnesia. Theories of retrograde amnesia have encompassed storage versus access disruption, physiological processes of`consolidation', the progressive transformation of episodic memories into a more`semantic' form, and multiple-trace theory. Single-case investigations, group studies and various forms of neuroimaging can all contribute to the resolution of these controversies.

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“…Patients with semantic memory deficits and intact episodic memory are at most very rare. It was for a time thought that patients with semantic dementia presented with such a pattern (Graham & Hodges, 1997;Hodges et al, 1992;Snowden et al, 1996), but recently it has become clear that episodic memory is by no means intact in semantic dementia (Graham et al, 2000;Westmacott et al, 2001). It may be that extended retrograde amnesia is in fact a semantic memory deficit-this is the portent of one view on temporally graded retrograde amnesia, semantization (Cermak, 1984;Meeter & Murre, 2004;Rosenbaum et al, 2001).…”

Section: Semantic Retrograde Amnesiamentioning

confidence: 99%

Retrograde amnesia for semantic information in Alzheimer's disease

Meeter

Kollen²,

Scheltens

2005

J Int Neuropsychol Soc

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Patients with mild to moderate Alzheimer's disease and normal controls were tested on a retrograde amnesia test with semantic content (Neologism and Vocabulary Test, or NVT), consisting of neologisms to be defined. Patients showed a decrement as compared to normal controls, pointing to retrograde amnesia within semantic memory. No evidence for a gradient within this amnesia was found, although one was present on an autobiographic test of retrograde amnesia that had a wider time scale. Several explanations for these results are presented, including one that suggests that extended retrograde amnesia and semantic memory deficits are in fact one and the same deficit. (JINS, 2005, 11, 40-48.)

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Semantic-Episodic Memory Interactions in Semantic Dementia: Implications for Retrograde Memory Function

Cited by 175 publications

References 0 publications

Verb acquisition and representation in Alzheimer's disease

Verb acquisition and representation in Alzheimer's disease

The loss of episodic memories in retrograde amnesia: single–case and group studies

Retrograde amnesia for semantic information in Alzheimer's disease

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