Self-targeting nanotherapy based on functionalized graphene oxide for synergistic thermochemotherapy

Shi, Dao; Zhuang, Jiangyuan; Fan, Zhongxiong; Zhao, Hai; Zhang, Xin; Su, Guanghao; Xie, Liping; Ge, Dongtao; Hou, Zhenqing

doi:10.1016/j.jcis.2021.06.072

Cited by 8 publications

(3 citation statements)

References 36 publications

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“…GO exhibits distinctive physical and chemical characteristics encompassing remarkable mechanical robustness, abundant oxygen-functional groups, and a high ratio of surface area. These attributes enable it to play a pivotal role in various biomedical engineering applications [48], nanomedicine advancements [49], tumor therapy strategies [50], drug release systems [51], and biological imaging techniques [52], among others. Compared to other spherical or flat nanomaterials, GO exhibits a significantly larger specific surface area along with superior strength and excellent biocompatibility.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Osteogenic Activity and Antibacterial Properties of Graphene Oxide-Poly(Lactic Acid) Films for the Repair of Cranial Defects in Rats

Liu,

Lai,

et al. 2024

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The failure of bone defect repair caused by bacterial infection is a significant clinical challenge. However, the currently utilized bone graft materials lack antibacterial properties, necessitating the development of bone repair materials with both osteoinductive and antibacterial capabilities. Graphene oxide (GO) has garnered considerable attention due to its distinctive physical, chemical, and biological characteristics. In this study, we prepared a graphene oxide-poly(lactic acid) (GO-PLA) film with exceptional biological properties. In vitro investigations demonstrated that the GO-PLA film substantially enhanced the adhesion and proliferation capacity of rat bone marrow mesenchymal stem cells (rBMSCs). Furthermore, we observed augmented alkaline phosphatase activity as well as increased expression levels of osteogenic genes in rBMSCs cultured on the GO-PLA film. Additionally, we evaluated the antibacterial activity of our samples using gram-positive Streptococcus mutans (Sm) and gram-negative Actinobacillus actinomycetemcomitans (Aa). Our findings revealed that GO doping significantly inhibited bacterial growth. Moreover, implantation experiments conducted on rat skull defects demonstrated excellent guided bone regeneration performance exhibited by the GO-PLA film. Overall, our results indicate that the GO-PLA film possesses outstanding osteogenic and antibacterial properties, making it a promising biomaterial for bone tissue regeneration.

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Section: Discussionmentioning

confidence: 99%

Enhanced Osteogenic Activity and Antibacterial Properties of Graphene Oxide-Poly(Lactic Acid) Films for the Repair of Cranial Defects in Rats

Liu,

Lai,

et al. 2024

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“…When the chemotherapeutic agents are packed as nano-drugs, the spatial distribution can be further controlled and targeted to decrease the byproduct of chemotherapy by application of thermal energy [ 58 ] with therapeutic effect enhanced and side effects decreased from the followed aspects.…”

Section: Cancer Treatments Combined With Thermal Therapymentioning

confidence: 99%

“…When nano-drugs in the cancer tissue serve as multiple thermal sources, the special distribution of the nano-drugs generates a unique heating pattern and thus helps further focus the application of thermal energy [ 72 ]. Besides, by surface modification, the nano-particles would target the cell surface [ 58 , 73 ] or even subcellular structures such as mitochondria [ 74 ] and thus realizing heating targeted region accordingly. Also.…”

Section: Cancer Treatments Combined With Thermal Therapymentioning

confidence: 99%

Synergetic Thermal Therapy for Cancer: State-of-the-Art and the Future

et al. 2022

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As a safe and minimal-invasive modality, thermal therapy has become an effective treatment in cancer treatment. Other than killing the tumor cells or destroying the tumor entirely, the thermal modality results in profound molecular, cellular and biological effects on both the targeted tissue, surrounding environments, and even the whole body, which has triggered the combination of the thermal therapy with other traditional therapies as chemotherapy and radiation therapy or new therapies like immunotherapy, gene therapy, etc. The combined treatments have shown encouraging therapeutic effects both in research and clinic. In this review, we have summarized the outcomes of the existing synergistic therapies, the underlying mechanisms that lead to these improvements, and the latest research in the past five years. Limitations and future directions of synergistic thermal therapy are also discussed.

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