Synergetic Thermal Therapy for Cancer: State-of-the-Art and the Future

Dai, Qizheng; Cao, Bo; Zhao, Shiqing; Zhang, Aili

doi:10.3390/bioengineering9090474

Cited by 6 publications

(5 citation statements)

References 157 publications

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“…This method uses heat from a heating agent to locally treat cancer. This method is considered to be a safe and minimally invasive method. , One of its striking features compared to drug-based treatment is that thermal therapies can be used repeatedly without generating resistance . Thermal therapy is divided into two types according to the operative temperature: (i) thermal ablation (>55 °C) and (ii) hyperthermia (>39–45 °C).…”

Section: Heating Agent Using Iron Oxidesmentioning

confidence: 99%

Crafting Iron Oxides for Next-Generation Biomedical Applications

Amrillah,

Notodidjojo,

Kalimanjaro

et al. 2024

Crystal Growth & Design

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Iron oxides are multifunctional materials that have been extensively explored for many applications, including in novel biomedical applications. However, boosting their ability for biomedical purposes remains a significant challenge. Many strategies have been proposed to increase the feasibility of iron oxides for biomedical applications, such as doping and defect engineering, compositing and decorating, surface and interface engineering, and structure and morphology development. This review focuses on the essential advancements of iron oxides for their implementation in biomedical applications. The discussion starts with the design of iron oxides in biomedical applications, such as drug delivery, heat delivery, contrast agents, biomedical nanorobots, and disease-sensing systems. We also discuss the obstacle of iron oxides in biomedical applications and continue by proposing a plausible strategy to enhance the feasibility of iron oxides in biomedical applications. The provided discussion and perspectives can enrich the information and pave the way to finding strategies to enhance the feasibility of iron oxides in biomedicalrelated applications. We believe that our review also could shed light on how to bring iron oxides close to real implementation for biomedical purposes.

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Section: Heating Agent Using Iron Oxidesmentioning

confidence: 99%

Crafting Iron Oxides for Next-Generation Biomedical Applications

Amrillah,

Notodidjojo,

Kalimanjaro

et al. 2024

Crystal Growth & Design

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“…[18] Combining these modalities can be beneficial in terms of increasing each other's efficiency or reducing the required dose of chemotherapeutic agents or thermal energy. [19] Here, we demonstrate combined chemotherapy and photothermal ablation applications using microrollers. The magnetic microrollers were composed of mesoporous 3 μm silica particles, half coated with a magnetic nickel (Ni) layer, enabling not only magnetically powered locomotion but also photothermal heating of the microrollers along with the gold (Au) layer.…”

Section: Introductionmentioning

confidence: 99%

“…[ 18 ] Combining these modalities can be beneficial in terms of increasing each other's efficiency or reducing the required dose of chemotherapeutic agents or thermal energy. [ 19 ]…”

Section: Introductionmentioning

confidence: 99%

Magnetic Mesoporous Janus Microrollers for Combined Chemo‐ and Photothermal Ablation Therapy

Aybar Tural,

Bozuyuk,

Dogan

et al. 2023

Advanced Therapeutics

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Mobile microrobots have been proposed as a promising approach to overcome the limitations of traditional drug/gene delivery systems. Magnetically actuated surface rolling microrobots, or magnetic surface microrollers, have shown potential for navigation in physiologically relevant environments due to their robust locomotion characteristics. Although much is known about their locomotion abilities in various environments, the full extent of their potential in medical applications has yet to be fully explored. Here, we demonstrate the potential of surface microrollers for combined chemo‐ and photothermal ablation therapy under medical imaging modalities. The surface microrollers were half‐coated with magnetic material, allowing for photothermal heating and magnetic locomotion, and loaded with a Biopharmaceutics Classification System Class IV anti‐cancer drug, Docetaxel, for combined therapy. Synergistic action of on‐demand photothermal ablation and controlled release of Docetaxel resulted in efficient elimination of cancer cells. Furthermore, microrollers could be detected ex vivo with magnetic resonance imaging and photoacoustic imaging, highlighting the potential of surface microrollers for future targeted medical applications.This article is protected by copyright. All rights reserved

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“…The production of cytokines that modulate inflammation and the activation of inflammatory cells are crucial for balancing the immune response. Consequently, HSP70 induced by hyperthermia and other therapies exhibits effects on various diseases, including neurodegenerative disorders like Alzheimer’s and Parkinson’s disease ( 95 ), metabolic syndrome ( 96 ), cancer ( 97 , 98 ), and allergic conditions such as asthma ( 84 , 99 ). These effects are attributed to the activation of the immune system through HSP70 expression, leading to enhanced natural healing capabilities.…”

Section: Introductionmentioning

confidence: 99%

Maintenance of homeostasis by TLR4 ligands

Oda,

Yamamoto,

Kawakami

2024

Front. Immunol.

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Immunotherapy is renowned for its capacity to elicit anti-infective and anti-cancer effects by harnessing immune responses to microbial components and bolstering innate healing mechanisms through a cascade of immunological reactions. Specifically, mammalian Toll-like receptors (TLRs) have been identified as key receptors responsible for detecting microbial components. The discovery of these mammalian Toll-like receptors has clarified antigen recognition by the innate immune system. It has furnished a molecular foundation for comprehending the interplay between innate immunity and its anti-tumor or anti-infective capabilities. Moreover, accumulating evidence highlights the crucial role of TLRs in maintaining tissue homeostasis. It has also become evident that TLR-expressing macrophages play a central role in immunity by participating in the clearance of foreign substances, tissue repair, and the establishment of new tissue. This macrophage network, centered on macrophages, significantly contributes to innate healing. This review will primarily delve into innate immunity, specifically focusing on substances targeting TLR4.

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Synergetic Thermal Therapy for Cancer: State-of-the-Art and the Future

Cited by 6 publications

References 157 publications

Crafting Iron Oxides for Next-Generation Biomedical Applications

Crafting Iron Oxides for Next-Generation Biomedical Applications

Magnetic Mesoporous Janus Microrollers for Combined Chemo‐ and Photothermal Ablation Therapy

Maintenance of homeostasis by TLR4 ligands

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