Self-setting particle-stabilized foams with hierarchical pore structures

Juillerat, Franziska Krauss; Gonzenbach, Urs T.; Studart, André R.; Gauckler, Ludwig J.

doi:10.1016/j.matlet.2010.03.062

Cited by 30 publications

(35 citation statements)

References 9 publications

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“…For the present study, foams made from alumina particles were combined with a calcium aluminate cement reaction. 18,19 Upon setting and sintering, open-porous scaffolds with different microstructures, which can be machined into the desired shapes, were produced, characterized and engineered with human bone-derived cells. In the present feasibility study, we investigated three scaffolds with various pores and pore openings for biocompatibility and the adhesion behavior, the inscaffold viability and the metabolic activity of human bone-derived cells, using first human osteosarcoma cells to select the scaffolds with optimal porosities, then primary human fetal osteoblasts 25,26 as potential histocompatible cells 9 for cell-engineering the scaffolds prior to their implantation into patient receivers.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][16][17] The adaption of this foaming method allowed the production of macroporous scaffolds which are tailorable not only in pore size, but also in pore interconnectivity. 18,19 In the present study, we made use of this direct foaming method to produce scaffolds from calcium aluminate and evaluated them as potential permanent bone graft materials. To obtain porous scaffolds with different microstructures, ceramic foams with varying pore sizes and porosities were produced from slightly varying compositions ( Table 1).…”

Section: Preparation and Characterization Of The Scaffoldsmentioning

confidence: 99%

“…[10][11][12] In the present study, our goals were to develop calcium aluminate scaffolds suitable for permanent bone replacement, displaying an open-porous channel microstructure allowing the engraftment and migration through the ceramics of human histocompatible bone-derived cells. The calcium aluminate scaffolds were produced from a modified direct foaming method [13][14][15][16][17][18][19] which allows the production of macroporous scaffolds which are tailorable in pore size, microstructure and shape. In particular we aimed to determine the optimal pore sizes to allow survival and migration of these human bone-derived cells across the scaffolds.…”

Section: Introductionmentioning

confidence: 99%

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Functionalization of Microstructured Open-Porous Bioceramic Scaffolds with Human Fetal Bone Cells

et al. 2012

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Bone substitute materials permissive for trans-scaffold migration and in-scaffold survival of human bone-derived cells are mandatory to develop cell-engineered permanent implants to repair bone defects. In this study, we evaluated the influence on human bone-derived cells of the material composition and microstructure of foam scaffolds made from calcium aluminate using a direct foaming method allowing wide-range tailoring of the microstructure for pore size and pore openings. Human fetal osteoblasts attached to the scaffolds, migrated across the entire materials depending on the scaffold pore size, colonized and survived in the porous material for at least 6 weeks. The long-term biocompatibility of the scaffold material for human cells was evidenced by in scaffold determination of cell metabolic activity using a modified MTT assay, a repeated WST-1 assay and scanning electron microscopy. Finally, we demonstrated that the fetal cells can be covalently bound to the scaffolds using biocompatible click chemistry, thus enhancing the rapid adhesion of the cells to the scaffolds. Thus, the different microstructures of the foams influenced the migratory potential of the cells, but not cell viability, and the scaffolds were permissive for covalent biocompatible chemical binding of the cells to the materials, allowing either localized or widespread cellularization of the scaffolds for cell-engineered implants.

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Section: Discussionmentioning

confidence: 99%

Section: Preparation and Characterization Of The Scaffoldsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Functionalization of Microstructured Open-Porous Bioceramic Scaffolds with Human Fetal Bone Cells

et al. 2012

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“…1)3) The dielectric resonators made from tin modified ZrTiO 4 for satellite telecommunication ranging from cellular telephones to global positioning systems has been a focus of great interest. 4) Solid state reactions has been used in the preparation of ZrTiO 4 based ceramics traditionally, with ZrO 2 and TiO 2 powders at high temperatures (above 1400°C).…”

Section: Introductionmentioning

confidence: 99%

ZrO<sub>2</sub>–TiO<sub>2</sub> porous ceramics from particle stabilized wet foam by colloidal processing

Bhaskar

Park

Lee

et al. 2016

J. Ceram. Soc. Japan

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ZrO 2 TiO 2 porous ceramics recently has been great interest in the dielectric resonator materials, as well as in the fields of preparation of optical devices, and bio materials. This study reveals an approach for the production of micro porous ceramics consisting of TiO 2 and ZrO 2 fabricated by colloidal wet processing. ZrO 2 particles in the colloidal suspension was partially hydrophobized using propyl gallate as an amphiphile, with a suitable pH range. The different mole ratios of the TiO 2 suspension was added to the surface modified ZrO 2 suspension. The contact angle was found to be around 75°with the adsorption free energy of 1.8 © 10 ¹11 2.15 © 10 ¹11 J. The Laplace pressure of about 1.481.24 mPa was determined corresponding to the wet foam stability of about 7680%. The microstructure analysis is done after sintering the dried samples for obtaining the porous ceramics.

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“…As far as we know, no group has studied a self-setting particle-stabilized zeolite foam, though several recent reports show the possibility of a self-setting particle-stabilized direct foaming method using calcium aluminate cement. 14) 16) In this study, we used a commercial calcium aluminate cement as a reactive phase to consolidate a particle-stabilized zeolite wet foam to eliminate the need for a sintering process. Incidentally, we did not consider adding zeolite to an autoclaved aerated concrete (AAC) foam.…”

Section: Introductionmentioning

confidence: 99%

Successful preparation of self-setting particle-stabilized zeolite 13X foams

Jung

Ahmad

et al. 2014

J. Ceram. Soc. Japan

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Zeolites are commonly used as adsorbents for a wide range of industrial applications. Recently, to alleviate the pressure drop and mass-transfer problems when zeolites are used as pellets in a packed bed system, the need for a self-standing zeolite foam has grown. Therefore, in this study, a zeolite 13X wet foam was stabilized by zeolite 13X particles that were rendered partially hydrophobic by propyl gallate, mixed with a commercial calcium aluminate cement, and then self-set. A self-setting particlestabilized zeolite 13X foam contains primary macropores with a size range of approximately 200 to 400¯m formed by zeolite 13X particles that are irreversibly adsorbed at liquidgas interfaces as well as secondary inherent micropores. In addition, we investigated the pore characteristics of the self-setting particle-stabilized zeolite 13X foams by scanning electron micrography, mercury porosimetry, physisorption analysis, and capillary flow porosimetry.

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Self-setting particle-stabilized foams with hierarchical pore structures

Cited by 30 publications

References 9 publications

Functionalization of Microstructured Open-Porous Bioceramic Scaffolds with Human Fetal Bone Cells

Functionalization of Microstructured Open-Porous Bioceramic Scaffolds with Human Fetal Bone Cells

ZrO<sub>2</sub>–TiO<sub>2</sub> porous ceramics from particle stabilized wet foam by colloidal processing

Successful preparation of self-setting particle-stabilized zeolite 13X foams

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Self-setting particle-stabilized foams with hierarchical pore structures

Cited by 30 publications

References 9 publications

Functionalization of Microstructured Open-Porous Bioceramic Scaffolds with Human Fetal Bone Cells

Functionalization of Microstructured Open-Porous Bioceramic Scaffolds with Human Fetal Bone Cells

ZrO<sub>2</sub>&ndash;TiO<sub>2</sub> porous ceramics from particle stabilized wet foam by colloidal processing

Successful preparation of self-setting particle-stabilized zeolite 13X foams

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ZrO<sub>2</sub>–TiO<sub>2</sub> porous ceramics from particle stabilized wet foam by colloidal processing