Self-Reported Taste and Smell Disorders in Patients with COVID-19: Distinct Features in China

Song, Jia; Deng, Yi‐Ke; Wang, Hai; Wang, Zhichao; Liao, Bo; Ma, Jin; He, Chao; Li, Pan; Liu, Yang; Alobid, Isam; Wang, Deyun; Zeng, Ming; Mullol, Joaquim; Liu, Zheng

doi:10.21203/rs.3.rs-52752/v1

Cited by 7 publications

(4 citation statements)

References 27 publications

(71 reference statements)

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“…al. 6 , and self-reported by patients in a retrospective study conducted early in the pandemic 24 . Other symptoms experienced by Sudanese patients were sore throat and headache.…”

Section: Discussionmentioning

confidence: 99%

The Distribution and Determinants of COVID-19 in Sudan, 2020/2021: Analysis of Surveillance Data

Abdullah

Mohammed

Ibrahim³

et al. 2022

Preprint

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Background Since the first case of COVID-19 in Sudan was reported in March 2020, the Federal Ministry of Health adopted an active surveillance system to collect and analyze information from the isolation centers and public and private laboratories about all suspected and confirmed COVID-19 cases. This study used the surveillance data to better understand the distribution and determinants of COVID-19 in Sudan and to construct a threshold level beyond which the dramatic surge may occur. Methods Data of suspected and confirmed COVID-19 cases were extracted from the line list prepared by the Surveillance and Information Department at the Federal Ministry of Health after obtaining ethical approval from the National Ethics Committee. Data were cleaned, coded, and analyzed using SPSS version 21. Frequencies and proportions were used to describe data. A univariate logistic regression analysis was used to determine the association of variables with the positivity of COVID-19. Variables with p-values < 0.05 in the univariate logistic analyses were included in multivariable logistic regression to determine the adjusted odds ratios (ORs) and their 95% confidence interval (CI). A two-sided α of less than 0.05 (p < 0.05) was considered statistically significant. Results Out of 48,545 suspected cases, 27,453 were positive. Four waves were seen, with a distinct explosion point of around 200 cases observed nationwide. Khartoum reported the highest number of cases. Of those tested positive, 16,444 (59.9%) were male and 11,009 (40.1%) were female. The mean (SD) age of cases was 41.1 (19.0) years with 21.6% of cases above 60 years. 14,780 (53.8%) of cases were asymptomatic. Fever, cough, shortness of breath, and loss of smell and taste were reported in 32.7%, 26.4%, 19.1 and 4.5% of confirmed cases, respectively. A total of 1,793 confirmed cases died; the case fatality rate was 6.5%. A considerable proportion of infection was reported among health workers. A univariate logistic regression analysis revealed that being symptomatic is significantly associated with testing negative for COVID-19 (odds ratio < 1). Conclusions COVID-19 was widely spread in Sudan with more cases in Khartoum, the capital of Sudan. The country experienced four waves with an observable epidemic explosion point of around 200 positive cases per week nationwide. Around half of the patients were asymptomatic; however, fever, cough, and shortness of breath were the commonest symptoms. The CFR all through was 6.5%, with death having a strong association with age. Further studies are recommended to clarify the image, especially among health workers. The study also highlighted the need to improve the quality of surveillance data.

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“…al. 6 , and self-reported by patients in a retrospective study conducted early in the pandemic 24 . Other symptoms experienced by Sudanese patients were sore throat and headache.…”

Section: Discussionmentioning

confidence: 99%

The Distribution and Determinants of COVID-19 in Sudan, 2020/2021: Analysis of Surveillance Data

Abdullah

Mohammed

Ibrahim³

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Approximately 80% of all COVID-19 patients with smell and taste impairment are reported to regain their sense of smell and taste impairment within 2 weeks of the COVID-19 cure. 65…”

Section: Hypogeusia and Hyposmiamentioning

confidence: 99%

Update on neurological symptoms in patients infected with severe acute respiratory syndrome coronavirus‐2

Xiao

You

Zeng

et al. 2021

Ibrain

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is the latest and most intense epidemic, which is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In addition to causing respiratory symptoms, SARS-CoV-2 can have severe effects on the nervous system. Clinically, COVID-19 patients have been reported ranging from mild hypogeusia and hyposmia to severe neurological disorders, such as encephalopathy, encephalitis, strokes, and seizures syndrome. However, the pathological mechanisms of this SARS-CoV-2 neuro aggressiveness remain unclear, so it is of great significance to explore the neurological effects of SARS-CoV-2 infection. To facilitate clinicians to timely recognize the manifestations of COVID-19 patients with neurological injury and timely treatment, the author hereby reviews the latest research progress in the possible pathways, clinical manifestations, and pathogenesis of COVID-19 patients with nerve injury.

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“…The study from China reported 5%-25% patients have smell and/or taste disorder(Jia Song et al 2021;Mao et al 2020). Omicron variant, which firstly detected in South Africa in November 2021, has become the main epidemic strain in the world by 15 January 2022 (Menni et al 2022;Hu et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Smell, taste and chemesthesis disorders in patients with the SARS-CoV-2 Omicron variant in China

Chen

Liu

et al. 2023

Preprint

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Many studies have confirmed that chemosensory disorder (including smell, taste and chemesthesis) is one of the symptoms of COVID-19 infection. However, new data indicated that the changes of chemosensory sensation caused by COVID-19 may be different among different populations and COVID-19 variants. At present, there are few studies focusing on the influence of Omicron on qualitative changes and quantitative reductions of chemosensory in China. We conducted a cross‑sectional study on COVID-19 Omicron variant patients to investigate the prevalence of chemosensory disorders and their chemosensory function before and during infection by online questionnaire. A total of 1245 patients with COVID-19 completed the study. The prevalence of smell, taste and chemesthesis disorder was 69.2%, 67.7% and 31.4% respectively. Sex, age, smoking and COVID-19-related symptoms such as lack of appetite, dyspnea and fatigue may have association with chemosensory disorders during COVID-19. Self-ratings of chemosensory function revealed that patients experienced a decline in the function of smell, taste and chemesthesis generally. Further studies are needed to combine the data using objective assessment and investigate the factors affecting chemosensory in COVID-19 through longitudinal research.

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Self-Reported Taste and Smell Disorders in Patients with COVID-19: Distinct Features in China

Cited by 7 publications

References 27 publications

The Distribution and Determinants of COVID-19 in Sudan, 2020/2021: Analysis of Surveillance Data

The Distribution and Determinants of COVID-19 in Sudan, 2020/2021: Analysis of Surveillance Data

Update on neurological symptoms in patients infected with severe acute respiratory syndrome coronavirus‐2

Smell, taste and chemesthesis disorders in patients with the SARS-CoV-2 Omicron variant in China

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