Self-report prevalence and associated factors to drug hypersensitivity in Mexican young adults

Abstract

BackgroundDrug hypersensitivity is defined as any unfavorable reaction that occurs after the administration of any drug. It may or may not be mediated by the involvement of the immune system. Epidemiological data related to drug hypersensitivity reactions in our country are scarce.ObjectiveTo determine the prevalence of drug hypersensitivity in a group of young adults, as well as to identify associated factors.MethodsA structured questionnaire was applied to young people aged 18 to 25 years. The instrument was oriented to identify reactions of drug hypersensitivity, as well as the most prevalent drugs involved. In addition, a personal and family history of atopic diseases was included. Analysis for associations between variables was been done through logistic regression.ResultsThe prevalence of drug hypersensitivity reactions was 12% (144 of 1,200). The antibiotics were the agents most related to hypersensitivity reactions (9.8%) followed by nonsteroidal anti-inflammatory drugs (1.6%). Factors associated with drug hypersensitivity were a personal history of asthma, odds ratio (OR) 3.15 (95% confidence interval [CI], 1.44–6.91), maternal and paternal history of drug hypersensitivity, OR 2.33 (95% CI, 1.21–4.48) and OR 3.11 (95% CI, 1.22–7.92), respectively.ConclusionThe results of this research show that drug hypersensitivity in young adults is a highly prevalent event and it is associated with personal history of asthma and history of drug hypersensitivity in parents.

Attitudes of dental practitioners towards antimicrobial therapy in Croatia and Bosnia and Herzegovina

“…19 Previous studies showed that antimicrobials induced hypersensitivity reactions are in high prevalence. [20][21][22][23][24][25] Also worrisome is the finding that 13% were undecided and 26% of respondents agreed that pregnant women and breastfeeding women should not use any antimicrobials. Antimicrobial treatment of infections is important for the health of women and their children during pregnancy.…”

“…Adverse effects are common in treatment with antibiotics . Previous studies showed that antimicrobials induced hypersensitivity reactions are in high prevalence . Also worrisome is the finding that 13% were undecided and 26% of respondents agreed that pregnant women and breastfeeding women should not use any antimicrobials.…”

Self-Reported Drug Hypersensitivity Amongst Late Adolescents in Mexico: A Population Based Study

“…Lastly, we found a significant association between a personal history of asthma and prevalence of DHR. Multiple studies conducted around the world, including Mexico, support the hypothesis that allergic conditions are a risk factor for drug hypersensitivity [1,3,5,6].…”

“…Epidemiological studies have shown that more than 5% of the population have experienced a DHR at some point in their lives [1][2][3]. For many years, antibiotics have been the main culprits, followed by nonsteroidal anti-inflammatory drugs (NSAIDs).…”

“…For many years, antibiotics have been the main culprits, followed by nonsteroidal anti-inflammatory drugs (NSAIDs). Risk factors for DHR include female sex, age, presence of allergic disease, ethnicity, and genetics [3][4][5][6]. Given the lack of previous studies aimed at defining the magnitude of DHR in Latin America, our main objective was to identify factors associated with the prevalence of DHR in late adolescents.…”