Self-Repair in Degenerative Joint Disease

Nicola, Valerio Di; Nicola, Renato Di

doi:10.2174/1874609811205030015

Cited by 6 publications

(6 citation statements)

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“…In Orthopaedics, omentum arthroplasty using omentum fragments or tiny patches to be allocated over the capsule bursa tissue may be considered to stimulate local MSCs and tissue recovery. Local stimulation of MSCs has already been proven effective to regenerate capsule bursa tissue and neo-cartilage formation in clinical research [116], [117], [118].…”

Section: Debate and Proposalsmentioning

confidence: 99%

Omentum a powerful biological source in regenerative surgery

Nicola

2019

Regenerative Therapy

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The Omentum is a large flat adipose tissue layer nestling on the surface of the intra-peritoneal organs. Besides fat storage, omentum has key biological functions in immune-regulation and tissue regeneration . Omentum biological properties include neovascularization, haemostasis, tissue healing and regeneration and as an in vivo incubator for cells and tissue cultivation. Some of these properties have long been noted in surgical practice and used empirically in several procedures. In this review article, the author tries to highlight the omentum biological properties and their application in regenerative surgery procedures. Further, he has started a process of standardisation of basic biological principles to pave the way for future surgical practice.

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Section: Debate and Proposalsmentioning

confidence: 99%

Omentum a powerful biological source in regenerative surgery

Nicola

2019

Regenerative Therapy

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“…Since 2012 the author has published work on procedures whose core effect is stimulation of joint resident MSCs [34,35]. A study mentioned in the work aimed to show long-term symptom control through the recovery of local cell homeostasis and tissue repair.…”

Section: Our Research and Innovative Proceduresmentioning

confidence: 99%

“…An observational clinical trial with 3 years follow-up showed a persistent improvement of symptoms together with a radiologic recovery of joints affected by degenerative Osteoarthritis. Lower pain level and increased joint mobility were observed in almost 80% treated patients and imaging often showed a downgrading of the degenerative OA [34,35]. Besides cartilage and bone regeneration, Gel Repair ® (in some preliminary experiences) has shown wound healing properties on chronic skin ulcers that did not respond to traditional treatments.…”

Section: Our Research and Innovative Proceduresmentioning

confidence: 99%

Regenerative Surgery Unit (RSU) a new model of care

Nicola¹

2020

Biomed Res Clin Prac

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Regenerative Surgery (RS) defines all the Regenerative Medicine (RM) treatments that can be applied through minimally invasive surgical procedures. This biomedical approach includes the use of stem cells, various local biochemical mediators, and tissue engineering.The Regenerative Surgery Unit (RSU) is a new model of health care governance integrating clinical, scientific and research activities.RSU works in a multidisciplinary setting involving surgeon, biologist, immunologist, laboratory technician, radiologist, and physiotherapist.RSU setting also aims to generate a special relation between doctor and patient. The aim of this relationship is to establish a solid and mutually beneficial alliance, founded on medical ethics, between doctor and patient.RSU organises clinical services through ambulatory care and day surgery settings. The scientific and research activities are integrated as components of daily medical practice.This article describes some established procedures in RS and some refinements that are more recently available as a result of our clinical and research experience in RM fields.Health Tourism is one element of the sustainable growth model we are developing in the RSU-Villa Aurora Hospital, Foligno (Italy).

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“…In our original research and clinical application we have made upa biomaterial composed by Polydeoxyribonucleotides (Pdrn), Hsps and a thickening-scaffolding substance finally being called Gel -Repairer. It works as a local Mesenchymal Stem Cells (MSCs) activator, ultimately generating connective tissue renewal [1,2].…”

Section: Introductionmentioning

confidence: 99%