Omentum a powerful biological source in regenerative surgery

Nicola, Valerio Di

doi:10.1016/j.reth.2019.07.008

Cited by 89 publications

(90 citation statements)

References 105 publications

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“…The integrity of the repair may be confirmed by the "tire test' (air insufflation via the nasogastric (NG) tube. The simplest method which has amply stood the test of time is to plug the defect with a convenient frond of omentum which provides the stimulus for fibrin formation and tissue regeneration ( Figure 1C) (27). Cellan-Jones in 1929 (28) suggested omentoplasty without primary closure of the defect to prevent narrowing of the duodenum.…”

Section: Operative Managementmentioning

confidence: 99%

An Overview of Gastroduodenal Perforation

Weledji

2020

Front. Surg.

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Section: Operative Managementmentioning

confidence: 99%

An Overview of Gastroduodenal Perforation

Weledji

2020

Front. Surg.

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“…Even more importantly, the patient's anal function quickly returned to normal after the operation, whereas low rectal cancer patients with anastomotic leakage in the past have experienced a series of symptoms such as increased defecation frequency, urgency, di culty in defecation, and incontinence due to pelvic in ammation, from which recovery is di cult. Other studies have found that the particular biological characteristics of the greater omentum can be used to treat brain injuries, hand trauma, and other defects, and has the ability to repair nerve tissue and promote regeneration (6,29,30). Research on whether the omental pedicle ap reconstruction of the mesorectum in the present study has similar restoration of neurological function as to accelerate the recovery of anal function is still lacking.…”

Section: Discussionmentioning

confidence: 99%

“…The prevention and treatment of postoperative LARS and other complications have become a global problem. By consulting the previous literature report (5), the author found that the greater omentum has become a natural material for surgeons to repair and reconstruct the damaged tissue (6). As an ideal source of biological tissue, we cut and transplanted the greater omentum ap into the presacral space to make the omentum adhere to the presacral in ammatory site.…”

Section: Introductionmentioning

confidence: 99%

A Study on the Clinical Application of Greater Omental Pedicle Flap Transplantation to Correct Anterior Resection Syndrome in Patients With Low Rectal Cancer

Qin

Meng

Huang

et al. 2020

Preprint

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PurposeLow anterior resection syndrome (LARS) is the most common complication after total mesorectal excision (TME) in patients with low rectal cancer and has been a challenge in colorectal surgery that severely impacts the quality of life of patients. This study aimed to introduce a revised surgical procedure which could effectively maintain rectal compliance and significantly improve LARS after the operation.MethodsWe performed mesorectal reconstruction after routine Dixon-TME using greater omental pedicle flap transplantation in 11 patients with low rectal cancer (5 cases of preoperative neoadjuvant chemoradiotherapy, 5 cases of preoperative neoadjuvant chemotherapy, and 1 case of postoperative adjuvant chemotherapy), thereby simulating the initial anatomical structure of the mesorectum and significantly reducing the postoperative anterior resection syndrome. The lars precision syndrome assessment scale (LARSS) was used to access the LARS.ResultsAt 12 weeks after the 11 patients recovered from the anal defecation function, the average score on the LARS questionnaire was 25.5 ± 0.5 (mild). The average time at which anal function began to recover was 6.2 ± 2.6 weeks after surgery. The recovery was rapid, as the rectal and anal function of all patients generally returned to normal levels within 12 weeks, and the quality of life was close to that before surgery. ConclusionGreater omental flap transplantation can significantly improve LARS after Dixon-TME in patients with low rectal cancer.

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“…However, they have a very short life span in the tissue if they are injected into a target. In many studies, the omentum has been used to wrap the injured tissue and has been shown to be useful (13). According to the results of a previous study, progression to chronic kidney failure has been shown to slow down after subtotal nephrectomy when omentum was used to cover the kidneys (11).…”

Section: Introductionmentioning

confidence: 99%

Contribution of Autologous Omentum Transposition to the Regeneration of Renal Injuries in the Rat Model

Bilgiç

İnce

Narter

2020

Preprint

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Aim: After renal trauma, surgical treatment is vital, but sometimes there may be loss of function due to fibrosis. We aimed to evaluate the repair effect of transpositioned autologous omentum on injured renal tissue in a rat model. Methods: A total of 30 female Wistar Albino rats were included and they were randomly separated into a sham group and four study groups. Iatrogenic renal injuries were repaired using a surgical technique (primary repair 1 and 2 groups) or transpositioned autologous omentum (omentum repair 1 and 2 groups). In all groups, blood samples were taken preoperatively and on the 7 th postoperative day in all groups and also on the 18 th postoperative day in the control and two study groups. All rats were sacrificed on the 7 th or 18 th day postoperatively and their right kidneys were taken for histopathological evaluation.Results: There was a trend toward decrease in urea and creatinine levels in all the groups. There was no significant correlation between urea and creatinine levels and histological finding scores. The omentum repair group had significantly lower inflammation and granulation scores compared with the primary repair and sham groups. There was a significant and positive correlation between inflammation and granulation and fibrosis scores. There was a significant and negative correlation between healing completion score and either inflammation and granulation scores. There were also positive correlations between histological findings in the kidney specimen and surrounding tissues. Conclusion: The use of the autologous omentum tissue for repair of kidney injury had attenuation effects on inflammation and granulation compared with primary repair. These results imply that use of omentum tissue to facilitate healing of kidney injury may theoretically lead to a more effective healing process and reduced fibrosis and tissue and function loss. These potentially beneficial effects of autologous omentum tissue should be investigated in further well-designed experimental and clinical studies.

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Omentum a powerful biological source in regenerative surgery

Cited by 89 publications

References 105 publications

An Overview of Gastroduodenal Perforation

An Overview of Gastroduodenal Perforation

A Study on the Clinical Application of Greater Omental Pedicle Flap Transplantation to Correct Anterior Resection Syndrome in Patients With Low Rectal Cancer

Contribution of Autologous Omentum Transposition to the Regeneration of Renal Injuries in the Rat Model

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