An Overview of Gastroduodenal Perforation

Weledji, Elroy Patrick

doi:10.3389/fsurg.2020.573901

Cited by 51 publications

(62 citation statements)

References 100 publications

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“…The PEI/PAA gel adhered on the stomach remained stable and exhibited no significant degradation after a 30-day implantation, indicating that the PEI/PAA gel can act as a physical barrier on the healed perforation site to provide protection for a longer period. Although the gastric perforation has healed, the healing tissue is still mechanically weak than healthy tissues in the early stage of 3 to 6 months after operation ( 55 , 56 ), and this may lead to a second gastric perforation in the short time. Therefore, we suggest that the stable PEI/PAA gel might act as a robust physical barrier on the healed wound site to avoid the recurrence of perforation.…”

Section: Discussionmentioning

confidence: 99%

Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations

et al. 2021

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Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an acute clinical demand because of the interfering interfacial water and limited adhesive-tissue interactions. Here we report a self-gelling and adhesive polyethyleneimine and polyacrylic acid (PEI/PAA) powder, which can absorb interfacial water to form a physically cross-linked hydrogel in situ within 2 seconds due to strong physical interactions between the polymers. Furthermore, the physically cross-linked polymers can diffuse into the substrate polymeric network to enhance wet adhesion. Superficial deposition of PEI/PAA powder can effectively seal damaged porcine stomach and intestine despite excessive mechanical challenges and tissue surface irregularities. We further demonstrate PEI/PAA powder as an effective sealant to enhance the treatment outcomes of gastric perforation in a rat model. The strong wet adhesion, excellent cytocompatibility, adaptability to fit complex sites, and easy synthesis of PEI/PAA powder make it a promising bioadhesive for numerous biomedical applications.

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Section: Discussionmentioning

confidence: 99%

Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations

et al. 2021

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“…However, the sites of lesion, in the gastroduodenal tract, show different occurrence chance of the complication. The major frequency of perforation is in duodenal ulcer, reaching 60%; in the antral and gastric body site, the ulcer perforation develops by 20% [23,24]. This clinical event is spontaneous.…”

Section: Perforationmentioning

confidence: 99%

“…The early management of perforated peptic ulcer encloses fluid infusion, intravenous proton pump inhibitor, antibiotics with wide antimicrobial activity, and positioning of the nasogastric tube. The central therapeutic role in the peptic ulcer perforation is played by surgery, usually by mini-invasive approach, following one of several procedures of surgical ulcer closure [23,24,28]. The altered conditions in the patients with every free perforation are indication to urgent surgery.…”

Section: Perforationmentioning

confidence: 99%

Introductory Chapter: Complications of Gastroduodenal Ulcers

Neri¹,

Ahmed²

2021

Esophagitis and Gastritis - Recent Updates

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“…TAWH are often accompanied by intra-abdominal injuries [ 3 ]. Gastric injury is suspected following penetrating or blunt abdominal injury [ 4 ]. Diagnosis requires careful examination and high index of suspicion [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Acute traumatic abdominal wall hernia—value of the physical examination: case report

Cervantes

Lopez

Lambert

et al. 2021

Journal of Surgical Case Reports

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Acute traumatic abdominal wall hernia (TAWH) is a rare type of hernia that occurs after a low or high velocity impact of the abdominal wall against a blunt object with few cases reported. Perforations of the hollow viscera commonly follow abdominal trauma and likely require surgery for hemorrhage and sepsis source control. We report a case where a high velocity impact of the abdominal wall against the stump of a felled tree caused a TAWH with concomitant gastric perforation in a 20-year-old male patient who required exploratory laparotomy with primary repair of the stomach and fascia. The physical examination findings without previous history of abdominal hernia and pneumoperitoneum in the chest X-ray made suspect our diagnosis and it was confirmed intraoperatively. At 3 months postoperatively the patient has a strong abdominal wall. It is imperative to emphasize the importance of the physical examination goal of not losing diagnosis of TAWH.

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An Overview of Gastroduodenal Perforation

Cited by 51 publications

References 100 publications

Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations

Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations

Introductory Chapter: Complications of Gastroduodenal Ulcers

Acute traumatic abdominal wall hernia—value of the physical examination: case report

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