Self-reinforcing hydrogels comprised of hydrophobic methyl methacrylate macromers copolymerized withN,N-dimethylacrylamide

Drug diffusion in hydrophobically modified N,N-dimethylacrylamide hydrogels

“…Therefore, hydrophobically modified hydrogels are of significant interest because their properties can be 'tuned'. Related studies have shown that 5-30 wt% of the hydrophobic monomer MMA can be copolymerized with DMA to achieve an optimal balance between mechanical strength and water content [7]. Equilibrium water contents from 70 to 97% and Young's modului from w0 to 0.5 MPa were achievable by varying the MMA concentration.…”

Synthesis of amphiphilic block copolymers based on poly(dimethylsiloxane) via fragmentation chain transfer (RAFT) polymerization

“…Optimizing oxygen permeability without losing transparency, mechanical integrity and surface hydrophilicity requires controlled phase separation via careful macromolecular design. In other work [13,14] we demonstrated that self-reinforcing hydrogels can be formed by copolymerizing hydrophobic macromonomers with hydrophilic monomers, in work originally inspired by Yamashita et al [15] and Tsukahara et al [16]. High moduli hydrogels were formed, and the mechanical integrity was postulated to originate from hydrophobic interactions of the macromonomer combs.…”

Synthesis, characterization, and evaluation of copolymers based on N‐isopropylacrylamide and 2‐ethoxyethyl methacrylate for the controlled release of felodipine

“…PNIPAAm has a lower critical solution temperature at 32°C in aqueous solutions2 because of the hydrogen‐bonding effect between water and amide groups of the polymer. The behavior of acrylamide‐based copolymers in water can be modified 3–6. In the case of PNIPAAm, modification has been carried out by the copolymerization of the hydrophilic or hydrophobic monomers, by the grafting of PNIPAAm with another polymer such as poly(ethylene oxide),7–9 or by the use of surface‐active compounds such as sodium dodecyl sulfate 10, 11 .…”