Drug diffusion in hydrophobically modified N,N-dimethylacrylamide hydrogels

Mullarney, Matthew P.; Seery, Thomas A. P.; Weiß, Robert

doi:10.1016/j.polymer.2006.03.096

Cited by 122 publications

(83 citation statements)

References 37 publications

(41 reference statements)

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“…4d). 4 Mullarney et al 37 reported similar kind of Fickian behaviour for the release of Pheniramine maleate through 38 using interpenetrating networks of poly(nisopropylacrylamide) and calcium alginate.…”

Section: Figs 3(a)mentioning

confidence: 84%

Utilization of Acrylamide and Natural Polysaccharide Based Polymeric Networks in Ph Controlled Release of 5-Amino Salicylic Acid

Kumar

Kaith

Mittal

2010

J. Chil. Chem. Soc.

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In this paper, psyllium (Psy) and acrylamide (AAm) based superabsorbent, synthesized using potassium persulphate (KPS) as an initiator and hexamethylene tetramine (HTMA) as a crosslinker, has been investigated for its swelling behaviour in distilled water as a function of time, temperature and pH. The hydrogel has further been applied for controlled delivery of 5-amino salicylic acid (5-ASA) under different pH conditions at 37 ºC. It has been found to show Fickian type mechanism as the drug release showed diffusion coefficient less than 0.50 for all the pH conditions.The gel characteristic constant has been found to show 6.9 × 10 -2 , 20.61 × 10 -2 and 33.4 × 10 -2 values for pH 4.0, 7.0 and 9.2, respectively. The initial diffusion coefficient has been found to show greater values than late diffusion coefficient confirming greater release at the early stages of the drug release than that in the late stages.

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Section: Figs 3(a)mentioning

confidence: 84%

Utilization of Acrylamide and Natural Polysaccharide Based Polymeric Networks in Ph Controlled Release of 5-Amino Salicylic Acid

Kumar

Kaith

Mittal

2010

J. Chil. Chem. Soc.

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“…For the Etters model, p, b, and k were 1.3390, 2.6001, and 10.5449, respectively [45]. To determine the diffusion coefficient of microfibre/LDPE composites, we applied equation 6, the "early-time" approximation which fits the sorption process.…”

Section: Diffusion Coefficient (D)mentioning

confidence: 99%

Organic Solvents Transport Through Alkali-Treated Agro-waste Microfibre Incorporated with Low Density Polyethylene Composites

Obasi¹

2017

AJPST

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Abstract:We report the transport behaviour of low density polyethylene composites containing both untreated and alkalitreated agro-waste microfibre in three aromatic organic solvents (benzene, toluene, and xylene) at 40, 60 and 80°C by the conventional weight-gain method. The effects of fibre content, alkali treatment, and filler particle size on solvent sorption were analysed. Transport parameters such as diffusion coefficient, sorption coefficient, and permeation coefficient have been calculated in terms of microfibre content, particle size, nature of the solvent, and temperature. It was observed that all the systems follow the Fickian mode of transport on increasing temperature. The van't Hoff's relationship was used to determine the thermodynamic parameters and was found that the estimated free energies of sorption were all positive, indicating nonspontaneity of the solubility of micro fibre/LDPE composites. The first order kinetic rate constant and swelling parameters were also evaluated.

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“…the artificial cornea (15), and to produce controlled drug delivery systems (12, 16,17). Their highly porous structure can easily be tuned by controlling the density of cross-links in the gel matrix, the affinity of the hydrogels for the aqueous environment in which they are swollen, and also allows drug loading into the gel matrix for subsequent drug release at a rate dependent on the diffusion coefficient of the drug through the gel network (13).…”

Section: Hydrogelsmentioning

confidence: 99%

Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

Ribeiro¹,

Figueiras²,

Veiga³

2015

J Pharm Pharm Sci

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-Purpose. Conventional ophthalmic systems present very low corneal systemic bioavailability due to the nasolacrimal drainage and the difficulty to deliver the drug in the posterior segment of ocular tissue. For these reasons, recent advances have focused on the development of new ophthalmic drug delivery systems. This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings in soft contact lenses (SCL) and the applications of novel pharmaceutical systems for ocular drug delivery. Among the new therapeutic approaches in ophthalmology, SCL are novel continuous-delivery systems, providing high and sustained levels of drugs to the cornea. The tendency of research in ophthalmic drug delivery systems development are directed towards a combination of several technologies (bio-inspired and molecular imprinting techniques) and materials (cyclodextrins, surfactants, specific monomers). There is a tendency to develop systems which not only prolong the contact time of the vehicle at the ocular surface, but also at the same time slow down the clearance of the drug. Different materials can be applied during the development of contact lenses and can be combined with natural inspired strategies of drug immobilization and release, providing successful tools for ocular drug delivery systems.

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Drug diffusion in hydrophobically modified N,N-dimethylacrylamide hydrogels

Cited by 122 publications

References 37 publications

Utilization of Acrylamide and Natural Polysaccharide Based Polymeric Networks in Ph Controlled Release of 5-Amino Salicylic Acid

Utilization of Acrylamide and Natural Polysaccharide Based Polymeric Networks in Ph Controlled Release of 5-Amino Salicylic Acid

Organic Solvents Transport Through Alkali-Treated Agro-waste Microfibre Incorporated with Low Density Polyethylene Composites

Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

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