Self‐Powered, Implantable, and Wirelessly Controlled NO Generation System for Intracranial Neuroglioma Therapy

Yao, Shuncheng; Zheng, Minjia; Wang, Zhuo; Zhao, Yunchao; Wang, Shaobo; Liu, Zhongfan; Zhou, Li; Guan, Yunqian; Wang, Zhong Lin; Li, Linlin

doi:10.1002/adma.202205881

Cited by 40 publications

(19 citation statements)

References 45 publications

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“…32,33 It has been reported that light, heat, or some metal ions could induce the S-N bond cleavage and cause NO to be released from GSNO. [34][35][36][37][38] Thus, the high photothermal conversion effect of BP provides a basis for the breakage of the S-N bond. To test this, 4, 5-diamino fluorescein (DAF-2) was used as an indicator to detect the released NO from the BN-MSs.…”

Section: Resultsmentioning

confidence: 99%

Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy

Liang,

Kuang,

Chen

et al. 2023

Smart Medicine

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Nitric oxide (NO) has shown great potential in tumor therapy, and the development of a platform for precise and controllable NO release still needs to be explored. Herein, a microfluidic electrospray strategy is proposed for the fabrication of hydrogel microspheres encapsulating NO donors (S‐nitrosoglutathione, GSNO) together with black phosphorus (BP) and chemotherapeutic doxorubicin (DOX) as microcarriers for tumor therapy. Based on the excellent photothermal property of BP and thermal sensitivity of GSNO, the microcarriers exhibit a near‐infrared light (NIR)‐responsive NO release behavior. Besides, the photothermal performance of the microcarriers accelerates the release of DOX. All these contribute to the excellent tumor‐killing effect of the microcarriers by combining multiple therapeutic strategies including NO therapy, photothermal therapy, and chemotherapy. Moreover, it was demonstrated that the NIR‐responsive NO delivery microcarriers could significantly inhibit tumor growth without apparent side effects in vivo. Therefore, it is believed that the novel NIR‐responsive NO microcarriers are promising candidates in clinical tumor therapy applications.

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Section: Resultsmentioning

confidence: 99%

Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy

Liang,

Kuang,

Chen

et al. 2023

Smart Medicine

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Section: Ng As a Power Source For The Cancer Therapymentioning

confidence: 99%

“…(wsTENG) with single-electrode mode. [85] The wsTENG could be attached to human body to collect energy from movement (Figure 3c). A NO releasing device (NO-LED) implanted transcranial close to tumor tissue was powered by the generated energy from wsTENG.…”

Section: Ng As a Power Source For The Cancer Therapymentioning

confidence: 99%

Emerging trends in materials and devices‐based electric stimulation therapy for tumors

Xie

Huang

Pereira

et al. 2023

BMEMat

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Electrical stimulation (ES), as one of the physical therapy modalities for tumors, has attracted extensive attention of researchers due to its promising efficacy. With the continuous development of material science, nanotechnology, and micro/nano processing techniques, novel electroactive nanomaterials and delicately designed devices have emerged to realize innovative ES therapies, which provide more possibilities and approaches for tumor treatment. Meanwhile, exploring the molecular biological mechanisms underlying different ES modalities affecting tumor cells and their immune microenvironment is also an unresolved hotspot emerging from the current biomedical engineering research. Focusing on the above research interests, in this review, we systematically summarized the effects of different ES parameters on the subcellular structure of tumor cells and the tumor immune microenvironment (TIME) in conjunction with the involved signaling pathways. In addition, we also reviewed the latest progress in novel self‐powered devices and electroactive nanomaterials for tumor therapy. Finally, the prospects for the development of electrostimulation tumor therapy are also discussed, bringing inspiration for the development of new physical therapy strategies in the future.

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“…The triboelectric nanogenerator (TENG) has become a promising candidate for the next generation of energy harvesting [ 1 , 2 ] and self-powered sensing platforms [ 3 , 4 , 5 , 6 ]. It possesses outstanding characteristics such as high energy conversion efficiency [ 7 , 8 ], abundant materials resource [ 9 , 10 ], a simple fabrication process [ 11 , 12 ] and multifunctional integration [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

A High Performance Triboelectric Nanogenerator Based on MXene/Graphene Oxide Electrode for Glucose Detection

et al. 2023

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A smart sensing platform based on a triboelectric nanogenerator (TENG) possesses various advantages such as self-powering, convenience, real-time and biocompatibility. However, the detection limit of the TENG-based sensor is required to be improved. In this study, a high performance TENG-based glucose sensor was proposed by using the Ti3C2Tx (MXene)/graphene oxide (GO) composite electrode. The MXene and GO nanosheets are popular 2D materials which possessed high conductivity and a rich surface functional group. The MXene/GO thin films were prepared through electrostatic self-assembly technology, which can effectively impede the agglomeration of two nanoflakes. The as-prepared MXene/GO film presented outstanding mechanical property. To figure out the relationship between the nanostructure of MXene/GO film and the TENG, a series of MXene/GO-based TENG with different GO sizes was characterized. As a result, the TENG with 400 nm GO demonstrated the highest output performance. Subsequently, the optimized TENG was used in glucose detection application without the assistance of a glucose enzyme. This simple and flexible TENG shows promising potential in biosensors and non-invasive health monitoring.

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Self‐Powered, Implantable, and Wirelessly Controlled NO Generation System for Intracranial Neuroglioma Therapy

Cited by 40 publications

References 45 publications

Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy

Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy

Emerging trends in materials and devices‐based electric stimulation therapy for tumors

A High Performance Triboelectric Nanogenerator Based on MXene/Graphene Oxide Electrode for Glucose Detection

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