Self-organization processes and phase transitions in nanocrystalline hydroxyapatite according to exoemission data

Krylova, I. V.; Ivanov, L. N.; Bozhevol’nov, V. E.; Северин, А. В.

doi:10.1134/s0036024407020161

Cited by 4 publications

(2 citation statements)

References 2 publications

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“…As the nanodimensional and nanocrystalline calcium orthophosphates tend to agglomerate at heating (Fig. 8) [313,[593][594][595], normally a low-temperature [169,371] and/or a rapid consolidation [169,258,323,[596][597][598][599][600][601][602] techniques must be employed. The low-temperature approach comprises gel hardening (at 4 ºC) [371] and uni-axial pressing at 150 -200 ºC [169].…”

Section: Bone Repairmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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Section: Bone Repairmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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“…Nevertheless, two general directions of the biomedical application of nanodimensional and nanocrystalline calcium orthophosphates can be outlined: (i) using them in powder form as filling materials to impart bioactivity to various biocomposites and hybrid biomaterials [52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,167,478]; (ii) manufacturing of either dense compacts or porous scaffolds, possessing the sufficient mechanical properties [62,79,264,265,464,465,479,480]. As the nanodimensional and nanocrystalline calcium orthophosphates tend to agglomerate at heating (Figure 6) [277,481,482,483], normally a low-temperature [157,297] and/or a rapid consolidation [157,235,286,484,485,486,487] techniques m...…”

Section: Biomedical Applications Of the Nanodimensional And Nanocrmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine

Dorozhkin¹

2009

Materials

243

150

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Recent developments in biomineralization have already demonstrated that nanosized particles play an important role in the formation of hard tissues of animals. Namely, the basic inorganic building blocks of bones and teeth of mammals are nanodimensional and nanocrystalline calcium orthophosphates (in the form of apatites) of a biological origin. In mammals, tens to hundreds nanocrystals of a biological apatite were found to be combined into self-assembled structures under the control of various bioorganic matrixes. In addition, the structures of both dental enamel and bones could be mimicked by an oriented aggregation of nanosized calcium orthophosphates, determined by the biomolecules. The application and prospective use of nanodimensional and nanocrystalline calcium orthophosphates for a clinical repair of damaged bones and teeth are also known. For example, a greater viability and a better proliferation of various types of cells were detected on smaller crystals of calcium orthophosphates. Thus, the nanodimensional and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the field of hard tissue engineering starting from bone repair and augmentation to the controlled drug delivery devices. This paper reviews current state of knowledge and recent developments of this subject starting from the synthesis and characterization to biomedical and clinical applications. More to the point, this review provides possible directions of future research and development.

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Biological and Medical Significance of Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

Biomedical Materials and Diagnostic Devices

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Self-organization processes and phase transitions in nanocrystalline hydroxyapatite according to exoemission data

Cited by 4 publications

References 2 publications

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine

Biological and Medical Significance of Nanodimensional and Nanocrystalline Calcium Orthophosphates

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