Self limiting lupus-like symptoms in patients with parvovirus B19 infection

Abstract

Figure 1 CT scan of the thorax showing marked pericardial effusion (arrow) and bilateral pleural effusions (left greater than right) (arrow): mediastinal windows.

Increased expression and secretion of interleukin-6 in human parvovirus B19 non-structural protein (NS1) transfected COS-7 epithelial cells

“…B19 infection has been associated with various forms of autoimmune diseases and may mimic SLE in children and adults [23,24]. There are striking analogies between the clinical features and haematological findings of SLE and those of B19 infection.…”

Generation of multifunctional murine monoclonal antibodies specifically directed to the VP1unique region protein of human parvovirus B19

“…Additionally, B19 infection has been associated with a variety of autoimmune diseases, as the clinical features of a B19 infection are frequently very similar to those of autoimmune phenomena, especially antiphospholipid syndrome (APS), characterized by the occurrence of antiphospholipid antibodies (aPL) (von Landenberg et al, 2003). For this reason, human parvovirus infections are often discussed as cause or trigger of various forms of autoimmune diseases like rheumatoid arthritis (Naides et al, 1990;Reid et al, 1985), juvenile idioblastic arthritis (Lehmann et al, 2002), autoimmune thrombopenia (Scheurlen et al, 2001) and systemic lupus erythematodes (SLE) Moore et al, 1999;Tovari et al, 2002).…”

Detection of parvovirus B19 DNA in the lesional skin of patients with Behçet's disease

“…Parvovirus B19 is a single‐stranded DNA virus with a genome of 5.6 kb, 6 Infections are common in humans, and are generally benign and self‐limiting with varying clinical presentation. Recently, this viral infection has been associated with systemic lupus erythematosus 7–14 . Serological studies of B19 were previously performed in BD, 15 but in this study, we applied the most sensitive method, real‐time polymerase chain reaction (RT‐PCR) to detect the virus quantitatively by amplification of B19 DNA 16 …”

“…Recently, this viral infection has been associated with systemic lupus erythematosus. [7][8][9][10][11][12][13][14] Serological studies of B19 were previously performed in BD, 15 but in this study, we applied the most sensitive method, real-time polymerase chain reaction (RT-PCR) to detect the virus quantitatively by amplification of B19 DNA. 16 In contrast to previous reports, we aimed to study the presence of B19 DNA in skin lesions of patients with BD and compare the results with those from the skin of healthy controls to evaluate the role of this virus in the pathogenesis.…”