Self-healing and injectable polysaccharide hydrogels with tunable mechanical properties

Liu, Hongchen; Li, Chaojing; Wang, Bijia; Sui, Xiaofeng; Wang, Lu; Yan, Xiaolin; Xu, Hong; Zhang, Linping; Zhong, Yi; Mao, Zhiping

doi:10.1007/s10570-017-1546-9

Cited by 61 publications

(33 citation statements)

References 50 publications

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“…However, the value of G′ is less than G″ on further increasing the strain. As reported in the literature, the point is explained by gel–sol transition and the interruption of the coordination interaction. Meanwhile, the gel–sol transition also points to the importance of the reversible coordination interaction.…”

Section: Methodssupporting

confidence: 54%

Microwave‐Assisted Reversible Coordination‐Mediated Polymerization for Self‐Healing Hybrid Materials: RGO@PDA Simultaneous as Catalyst and Nanocomposites in One‐Pot

Jiang

Wang

Bai

et al. 2019

Macro Materials & Eng

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In this article, polydopamine (PDA) is efficiently adhered on the surface of graphene oxide (GO) by mussel‐inspired chemistry. The obtained reduced GO/PDA (RGO@PDA) nanocomposites are used for catalyzing reversible coordination‐mediated polymerization under microwave radiation. Well‐defined and iodine‐terminated polyacrylonitrile‐co‐poly(n‐butyl acrylate) (PAN‐co‐PnBA) is successfully fabricated by using RGO@PDA nanocomposites as catalysts. Importantly, green and novel strategy of PAN‐co‐PnBA‐type self‐healing nanocomposite materials is further fabricated with RGO@PDA as additive after polymerization as catalyst in one‐pot. As a reinforcement agent, RGO@PDA can also improve the mechanical and self‐healing properties of hybrid materials, which opens up a novel and green methodology for the preparation of self‐healing hybrid materials.

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Section: Methodssupporting

confidence: 54%

Microwave‐Assisted Reversible Coordination‐Mediated Polymerization for Self‐Healing Hybrid Materials: RGO@PDA Simultaneous as Catalyst and Nanocomposites in One‐Pot

Jiang

Wang

Bai

et al. 2019

Macro Materials & Eng

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“…The literature has revealed that the mechanical properties of self-healing hydrogels could be adjusted by the chemical composition, solid contents, or type of composite hydrogels 15,[36][37][38] . Very recently, the self-healing properties of poly(2-acrylamido-2-methyl-1-propanesulfonic acid) hydrogels were also found to be tunable 39 .…”

Section: Discussionmentioning

confidence: 99%

Novel chitosan–cellulose nanofiber self-healing hydrogels to correlate self-healing properties of hydrogels with neural regeneration effects

et al. 2019

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Biodegradable self-healing hydrogels are attractive materials for tissue repair; however, the impact of the self-healing abilities of hydrogels on tissue repair is not clear. In this study, we prepared novel chitosan-cellulose nanofiber (CS-CNF) composite self-healing hydrogels with the same modulus (approximately 2 kPa) but tunable self-healing properties. By adding a low amount of CNFs (0.06-0.15 wt%) in the pristine chitosan (CS) self-healing hydrogel, the reversible dynamic Schiff bonding, strain sensitivity, and self-healing of the hydrogel are obviously affected. Neural stem cells embedded in the CS-CNF hydrogel with better self-healing properties reveal significantly enhanced oxygen metabolism as well as neural differentiation. The differentiation of neural stem cells is highly correlated with their metabolic change in the self-healing hydrogel. Moreover, the neural regeneration effect of the optimized CS-CNF hydrogel with 0.09 wt% CNFs and the best self-healing properties show a 50% improvement over the pristine CS hydrogel in the zebrafish brain injury model. A mechanism is proposed to interpret the tunable self-healing properties of CS-CNF hydrogels with stiffness maintained in a similar range. The new self-healing hydrogels help to clarify the role of self-healing in the biological performance of hydrogels as well as provide design rationale for hydrogels with better injectability and tissue regeneration potential.

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“…It was found that the CNC–NH 2 acted as a physical and chemical cross‐linker and the internal morphology, gelation time, and mechanical properties (significantly higher elastic modulus, with 150% increase at peak strength, compared to a hydrogel without the filler) was dependent on the loading of CNC–NH 2. In addition, L929 fibroblast cytotoxicity investigation demonstrated good biocompatibility …”

Section: Technological Potential Of Cncs: the Development Of A New Gementioning

confidence: 94%

Cellulose Nanocrystals as a Sustainable Raw Material: Cytotoxicity and Applications on Healthcare Technology

Pelegrini

Ré

Oliveira

et al. 2019

Macro Materials & Eng

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Cellulose nanocrystals (CNCs) are an environmentally friendly natural material, consisting of rod‐like crystalline nanoparticles, called whiskers, or nanocrystalline cellulose. The derivation of different natural sources, aligned to their biocompatibility, biodegradability, and versatility, make them a class of fascinating materials with widespread industrial use. In addition, the cellulose species possess intriguing physicochemical and mechanical properties. This paper provides an overview of recent progress in the area of cellulosic nanocomposites, along with details of their structure and liquid crystalline behavior as nematic and cholesteric lyotropic materials. Guidance is subsequently provided for the physicochemical analysis of these materials, including X‐ray diffraction, transmission electron microscopy, optical evaluation, thermogravimetric analysis, and differential scanning calorimetry. Additionally, the functional chemical and physical properties of CNCs are correlated to the resulting nanotoxicity in in vitro and in vivo assays. This review points to relevant concerns, such as sources for the synthesis of CNCs, the nanomaterial size, and the surface chemistry, that must be overcome in order to attain safe use of CNC‐based nanomaterials. The challenging perspectives on the ongoing research are presented in order to explore the technological and industrial perspectives on the use of CNC for the generation of cost‐effective advanced nanomaterials based on cellulosic fibers.

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Self-healing and injectable polysaccharide hydrogels with tunable mechanical properties

Cited by 61 publications

References 50 publications

Microwave‐Assisted Reversible Coordination‐Mediated Polymerization for Self‐Healing Hybrid Materials: RGO@PDA Simultaneous as Catalyst and Nanocomposites in One‐Pot

Microwave‐Assisted Reversible Coordination‐Mediated Polymerization for Self‐Healing Hybrid Materials: RGO@PDA Simultaneous as Catalyst and Nanocomposites in One‐Pot

Novel chitosan–cellulose nanofiber self-healing hydrogels to correlate self-healing properties of hydrogels with neural regeneration effects

Cellulose Nanocrystals as a Sustainable Raw Material: Cytotoxicity and Applications on Healthcare Technology

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