Novel chitosan–cellulose nanofiber self-healing hydrogels to correlate self-healing properties of hydrogels with neural regeneration effects

Cheng, Kun-Chih; Huang, Chih‐Feng; Wei, Yen; Hsu, Shan‐hui

doi:10.1038/s41427-019-0124-z

Cited by 125 publications

(67 citation statements)

References 64 publications

(75 reference statements)

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“…As shown in Scheme 1a, TOCNs were prepared according to the literature [4,49,50]. Paper pulp (15 g) was dispersed in 1000 mL of DI water with vigorous stirring for a few hours and then the filtrate was collected and washed with water to remove impurities.…”

Section: Methodsmentioning

confidence: 99%

Surface-Initiated Initiators for Continuous Activator Regeneration (SI ICAR) ATRP of MMA from 2,2,6,6–tetramethylpiperidine–1–oxy (TEMPO) Oxidized Cellulose Nanofibers for the Preparations of PMMA Nanocomposites

Tsai

Chang

et al. 2019

Polymers

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An effective method of oxidation from paper pulps via 2,2,6,6–tetramethylpiperidine–1–oxy (TEMPO) compound to obtain TEMPO-oxidized cellulose nanofibers (TOCNs) was demonstrated. Following by acylation, TOCN having an atom transfer radical polymerization (ATRP) initiating site of bromoisobutyryl moiety (i.e., TOCN–Br) was successfully obtained. Through a facile and practical technique of surface-initiated initiators for continuous activator regeneration atom transfer radical polymerization (SI ICAR ATRP) of methyl methacrylate (MMA) from TOCN–Br, controllable grafting polymer chain lengths (Mn = ca. 10k–30k g/mol) with low polydispersity (PDI < 1.2) can be achieved to afford TOCN–g–Poly(methyl methacrylate) (PMMA) nanomaterials. These modifications were monitored by Fourier-transform infrared spectroscopy (FT–IR), scanning electron microscopy (SEM), electron spectroscopy for chemical analysis (ESCA), and water contact angle analysis. Eventually, TOCN–g–PMMA/PMMA composites were prepared using the solvent blending method. Compared to the pristine PMMA (Tg = 100 °C; tensile strength (σT) = 17.1 MPa), the composites possessed high transparency with enhanced thermal properties and high tensile strength (Tg = 110 °C and σT = 37.2 MPa in 1 wt% TOCN containing case) that were investigated by ultraviolet-visible spectroscopy (UV-Vis), thermogravimetric analysis (TGA), dynamic mechanical analysis (DMA), and tensile tests. We demonstrated that minor amounts of TOCN–g–PMMA nanofillers can provide high efficacy in improving the mechanical and thermal properties of PMMA matrix.

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Section: Methodsmentioning

confidence: 99%

Surface-Initiated Initiators for Continuous Activator Regeneration (SI ICAR) ATRP of MMA from 2,2,6,6–tetramethylpiperidine–1–oxy (TEMPO) Oxidized Cellulose Nanofibers for the Preparations of PMMA Nanocomposites

Tsai

Chang

et al. 2019

Polymers

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“…Self-healing of organisms is a common phenomenon in nature. When injured by the outside world, life forms can heal themselves, which provides inspiration for self-healing materials [1][2][3][4] Therefore, the self-healing mechanism is widely used in a variety of materials, because it can increase the service life of materials and reduce the demand for resources. [5][6][7][8] As the surface protection of metal matrix and foundation building, coating is easy to be scratched and damaged by external materials, and the matrix may also be damaged.…”

Section: Introductionmentioning

confidence: 99%

A Thermosetting Polyurethane with Excellent Self‐Healing Properties and Stability for Metal Surface Coating

Xiang

et al. 2020

Macro Chemistry & Physics

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Polyurethane was mainly a linear or network polymer material containing urethane groups and the separation of hard segments and soft segments often occurred in polyurethane molecules because of the different compatibility of different component. [10-13] The hard segments are mainly composed of chain extenders and curing agents, which mainly affected the mechanical performance of polyurethane. The soft segments were mainly composed of long chain molecules with active groups at both ends, which affected the elasticity and toughness of polyurethane. Due to the controllability and transformation of the hard segment structure, some reversible covalent bonds can be introduced into polyurethane to prepare self-healing polyurethane materials. [14-16] For example thiol-disulfide exchange reactions(disulfide metathesis), [17,18] Diels-Alder reactions, [19] or Boron-oxygen bonding. [20] It has a nondynamic covalent bond, for example, hydrogen bonding, [21-24] metalligand coordination. [25,26] Judit et al. introduced disulfide groups into rubber network to allow the surface damage of the rubber to recover and the healing process to be repetitive. [27] Rekondo et al. prepared a novel poly(urea-urethane) thermoset elastomer with aromatic disulfide bond crosslinking, which can perform disulfide metathesis without catalyst and has certain self-healing capability in light and heat, but weak mechanical strength. [28] Kuhl et al. used acylhydrazones covalent crosslinkers for self-healing, analyzed the basic healing mechanism and corresponding mechanical performance. [7] Xu et al. synthesized a supramolecular elastomer PUU-g-C 3 N 4 NS material, which has both mechanical performance and room temperature self-healing capability, and the self-healing capability was derived from multiple supramolecular hydrogen bonds of PUU matrix. [29] Li et al. designed a highly stretchable and autonomous self-healing material by combining coordination complexes with various bond strengths as cross-links between polymer chains. [30] A large number of research have shown that the excellent self-healing performance of materials are favored by researchers. The research of self-healing coating materials will be the future development trend of coating materials. In this work, we prepared a supramolecular thermosetting self-healing polyurethane with excellent mechanical performance and thermal stability by a simple one-step method. The key to this design was to introduce exchangeable disulfide groups into the polyurethane network structure to achieve Self-healing performance of materials can greatly improve the life of materials and reduce their maintenance costs. Therefore, preparation of self-healing coating materials is expected to be the development trend of coating materials. In this paper, thermosetting polyurethane material (HTPB-PG-SS-TDI) is designed with excellent mechanical performance, thermal stability, acid-base resistance property, and self-healing capability by introducing SS (4,4-dihydroxy diphenyl dithioether) into thermosetting polyureth...

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“…Recently, Cheng et al exploited chitosan-cellulose nanofiber selfhealing hydrogels for neural regeneration. Improved neural differentiation and oxygen metabolism were observed upon embedding neural stem cells (Cheng et al, 2019). In other study by Li et al (2018) polyacrylamide grafted cellulose nanocrystals (CNC-g-PAM), as physical crosslinkers and interfacial compatible nanofillers, were incorporated into poly(acrylic acid) to develop NC hydrogels.…”

Section: Nano-scaled Cellulose: a Robust Nanomaterialsmentioning

confidence: 99%

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

et al. 2020

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Since the introduction of tissue engineering as an encouraging method for the repair and regeneration of injured tissue, there have been many attempts by researchers to construct bio-mimetic scaffolds which mimic the native extracellular matrix, with the aim of promoting cell growth, cell proliferation, and restoration of the tissue's native functionality. Among the different materials and methods of scaffold fabrication, one particularly promising class of materials, hydrogels, has been extensively studied, with the inclusion of nano-scaled materials into hydrogels leading to the creation of an exciting new generation of nanocomposites, known as nanocomposite hydrogels. To closely mimic the native tissue behavior, scientists have recently focused on the functionalization of incorporated nanomaterials via chiral biomolecules, with reported results showing great potential. The current article aims to introduce a perspective of nano-scaled cellulose as a promising nanomaterial which can be multi-functionalized for the fabrication of nanocomposite hydrogels with applications in tissue engineering and drug delivery systems. This article also briefly reviews the recently reported literature on nanocomposite hydrogels incorporated with chiral functionalized nanomaterials. Such knowledge paves the path for the development of tailored hydrogels toward practical applications.

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Novel chitosan–cellulose nanofiber self-healing hydrogels to correlate self-healing properties of hydrogels with neural regeneration effects

Cited by 125 publications

References 64 publications

Surface-Initiated Initiators for Continuous Activator Regeneration (SI ICAR) ATRP of MMA from 2,2,6,6–tetramethylpiperidine–1–oxy (TEMPO) Oxidized Cellulose Nanofibers for the Preparations of PMMA Nanocomposites

Surface-Initiated Initiators for Continuous Activator Regeneration (SI ICAR) ATRP of MMA from 2,2,6,6–tetramethylpiperidine–1–oxy (TEMPO) Oxidized Cellulose Nanofibers for the Preparations of PMMA Nanocomposites

A Thermosetting Polyurethane with Excellent Self‐Healing Properties and Stability for Metal Surface Coating

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

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