Self-Healable, Fast Responsive Poly(ω-Pentadecalactone) Thermogelling System for Effective Liver Cancer Therapy

Shi, Huihui; Luo, Zheng; Lu, Jiang; Loh, Xian Jun; He, Chaobin; Liu, Yupeng

doi:10.3389/fchem.2019.00683

Cited by 16 publications

(12 citation statements)

References 48 publications

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“…PPG blocks present peaks at 1.1 ppm, 3.4 ppm, and 3.5 ppm belonging to CH 3 , CH 2 , and CH, respectively. HDI linkages show specific peaks at 1.3 ppm, 1.5 ppm, and 3.1 ppm ascribed to CH 2 groups [ 42 ]. Referring to the 1 H NMR spectrum of MPOSS, the presence of MPOSS blocks in MPEP copolymers was confirmed by peaks at 0.9 ppm and 0.6 ppm that were attributed to seven CH 3 and CH 2 on the isobutyl groups.…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye

Han

Shi

et al. 2022

Bioactive Materials

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Dry eye is a common ocular disease that results in discomfort and impaired vision, impacting an individual's quality of life. A great number of drugs administered in eye drops to treat dry eye are poorly soluble in water and are rapidly eliminated from the ocular surface, which limits their therapeutic effects. Therefore, it is imperative to design a novel drug delivery system that not only improves the water solubility of the drug but also prolongs its retention time on the ocular surface. Herein, we develop a copolymer from mono-functional POSS, PEG, and PPG (MPOSS-PEG-PPG, MPEP) that exhibits temperature-sensitive sol-gel transition behavior. This thermo-responsive hydrogel improves the water solubility of FK506 and simultaneously provides a mucoadhesive, long-acting ocular delivery system. In addition, the FK506-loaded POSS hydrogel possesses good biocompatibility and significantly improves adhesion to the ocular surface. In comparison with other FK506 formulations and the PEG-PPG-FK506 (F127-FK506) hydrogel, this novel MPOSS-PEG-PPG-FK506 (MPEP-FK506) hydrogel is a more effective treatment of dry eye in the murine dry eye model. Therefore, delivery of FK506 in this POSS hydrogel has the potential to prolong drug retention time on the ocular surface, which will improve its therapeutic efficacy in the management of dry eye.

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Section: Resultsmentioning

confidence: 99%

Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye

Han

Shi

et al. 2022

Bioactive Materials

Self Cite

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“…Thermogels are also useful for lowering the critical micelle concentration (CMC), which means that micelles for drug delivery are much more easily formed than typical hydrogels and offer greater stability. This leads to a higher percentage of micelles reaching the targeted area for drug delivery and can provide better outcomes in medical usage [70].…”

Section: Thermogelsmentioning

confidence: 99%

Recent Progress in Biopolymer-Based Hydrogel Materials for Biomedical Applications

Mahmood

Patel

Hickson

et al. 2022

IJMS

114

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Hydrogels from biopolymers are readily synthesized, can possess various characteristics for different applications, and have been widely used in biomedicine to help with patient treatments and outcomes. Polysaccharides, polypeptides, and nucleic acids can be produced into hydrogels, each for unique purposes depending on their qualities. Examples of polypeptide hydrogels include collagen, gelatin, and elastin, and polysaccharide hydrogels include alginate, cellulose, and glycosaminoglycan. Many different theories have been formulated to research hydrogels, which include Flory-Rehner theory, Rubber Elasticity Theory, and the calculation of porosity and pore size. All these theories take into consideration enthalpy, entropy, and other thermodynamic variables so that the structure and pore sizes of hydrogels can be formulated. Hydrogels can be fabricated in a straightforward process using a homogeneous mixture of different chemicals, depending on the intended purpose of the gel. Different types of hydrogels exist which include pH-sensitive gels, thermogels, electro-sensitive gels, and light-sensitive gels and each has its unique biomedical applications including structural capabilities, regenerative repair, or drug delivery. Major biopolymer-based hydrogels used for cell delivery include encapsulated skeletal muscle cells, osteochondral muscle cells, and stem cells being delivered to desired locations for tissue regeneration. Some examples of hydrogels used for drug and biomolecule delivery include insulin encapsulated hydrogels and hydrogels that encompass cancer drugs for desired controlled release. This review summarizes these newly developed biopolymer-based hydrogel materials that have been mainly made since 2015 and have shown to work and present more avenues for advanced medical applications.

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“…The enhanced Hela cell apoptosis also proved the effectiveness of DOX and p‐Cur combined delivery. Besides, a novel synthetic DTX and DOX co‐delivered PPDL/PEG/PPG (PDEP) hydrogel 129 was applied for treating liver cancer. This copolymer hydrogel showed excellent self‐healing property and thermostability, which could be injected accurately toward carcinoma tissue and quickly transformed into gel in situ, maintaining the localized drug concentration for a long time.…”

Section: The Application Of Hydrogels In Localized Tumor Treatmentmentioning

confidence: 99%

Advances and trends of hydrogel therapy platform in localized tumor treatment: A review

Tan

Huang

et al. 2020

J Biomedical Materials Res

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Due to limitations of treatment and the stubbornness of infiltrative tumor cells, the outcome of conventional antitumor treatment is often compromised by a variety of factors, including severe side effects, unexpected recurrence, and massive tissue loss during the treatment. Hydrogel‐based therapy is becoming a promising option of cancer treatment, because of its controllability, biocompatibility, high drug loading, prolonged drug release, and specific stimuli‐sensitivity. Hydrogel‐based therapy has good malleability and can reach some areas that cannot be easily touched by surgeons. Furthermore, hydrogel can be used not only as a carrier for tumor treatment agents, but also as a scaffold for tissue repair. In this review, we presented the latest researches in hydrogel applications of localized tumor therapy and highlighted the recent progress of hydrogel‐based therapy in preventing postoperative tumor recurrence and improving tissue repair, thus proposing a new trend of hydrogel‐based technology in localized tumor therapy. And this review aims to provide a novel reference and inspire thoughts for a more accurate and individualized cancer treatment.

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Self-Healable, Fast Responsive Poly(ω-Pentadecalactone) Thermogelling System for Effective Liver Cancer Therapy

Cited by 16 publications

References 48 publications

Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye

Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye

Recent Progress in Biopolymer-Based Hydrogel Materials for Biomedical Applications

Advances and trends of hydrogel therapy platform in localized tumor treatment: A review

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