Self-expanding nitinol stents for bleeding from esophageal varices in patients with portal hypertension

Жигалова, С. Б.; Шерцингер, А. Г.; Manukyan, G. V.; Musin, R. A.; Markarov, A. E.; Bobyleva, Ya S

doi:10.17116/hirurgia202012146

Cited by 2 publications

(1 citation statement)

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“…Наиболее привлекательным является формирование у лабораторного животного подпечёночной портальной гипертензии [7]. Безусловно, она отличается патогенезом от наиболее распространённого в реальных клинических условиях внутрипечёночного варианта [8]. Однако, относительная простота и достаточная степень сходства гемодинамических изменений перевешивают указанные минусы.…”

Section: результатыunclassified

Method for increasing scientific value of portal hypertension modeling experiment

Федосеев

Budarev

Chekushin

2023

jour

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Aim: development and testing of a technically simple method for the formation of portal hypertension in the body of a domestic pig, which makes it possible to obtain a model that is close in key parameters to humans. Materials and methods. The material of the study was the results of an experiment conducted in the vivarium of the Ryazan State Medical University on 12 domestic pigs. Results. A method for modeling portal hypertension in the body of a domestic pig by dosed compression of the hepatoduodenal ligament with a plastic clamp was developed and tested. Conclusions. A model of portal hypertension was obtained, which makes it possible to obtain scientific data easily extended to humans, due to the similarity of the anatomy, physiology, and size of the used laboratory animal with those of humans.

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Section: результатыunclassified

Method for increasing scientific value of portal hypertension modeling experiment

Федосеев

Budarev

Chekushin

2023

jour

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An Alternative Option to Compression Hemostasis in Case of Esophageal Vein Bleeding in Patients with Portal Hypertension

Budarev,

Fedoseev

2024

VECS

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Introduction. Compression hemostasis is widely used to arrest bleeding from veins of the esophagus in portal hypertension. Since it has a number of severe drawbacks, research is relevant to develop new approaches to solve this problem.The aim of the study was to provide evidence and develop a technique to arrest bleeding from varicose veins of the esophagus, which can become an alternative to compression hemostasis.Materials and methods. The key technology in the study was chemical-mechanical hemostasis – the combined esophageal vein compression and Hemoblock application. At the first stage, this technique was tested on laboratory animals - domestic pigs, since a model of the esophageal vein bleeding was formed in their bodies. At the clinical stage, chemical-mechanical hemostasis was performed in 15 patients with the recurrent esophageal vein bleeding; they made up the experimental group. The control group consisted of 15 patients subjected to compression hemostasis. The hemostatic effectiveness of the techniques and their assessment by the patients themselves were compared in the study.Results. In the experimental group, bleeding was arrested in 46.7% of cases by installing a probe for chemical-mechanical hemostasis with a 5-minute exposure. In the control group, bleeding was arrested in 66.7% of cases by installing an obturator probe with a 10- to 24-hour exposure. As patients’ survey reported, in the control group, patients experienced pain during the insertion of the obturator probe in 86.7% of cases, and 20% of patients experienced pain during the entire time the obturator probe was in the esophagus; 93.3% of patients expected an early termination of the procedure, 13.3% claimed that they would never agree to the procedure again. As patients’ survey reported, in the experimental group, 6.7% of patients experienced pain when inserting the probe for chemical-mechanical hemostasis and during the time, it remained in the body. 46.7% of patients wanted the procedure to be terminated as soon as possible. There were no patients who refused to repeat a procedure of chemical-mechanical hemostasis if required.Conclusions. The study demonstrated that a modified conventional obturator probe, which allowed combining compression of the esophageal veins with the hemostatic drug effect, resulted in a significantly increased hemostatic effect in case of the esophageal vein bleeding. During the study, this technique prevented 46.7% of patients from the need to use an obturator probe. Since the obturator probe, when applied, causes a large number of troublesome and painful sensations (a fact reported by 93.3% of patients), even its partial elimination can be considered as an option improving the quality of the treatment.

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Self-expanding nitinol stents for bleeding from esophageal varices in patients with portal hypertension

Cited by 2 publications

References 5 publications

Method for increasing scientific value of portal hypertension modeling experiment

Method for increasing scientific value of portal hypertension modeling experiment

An Alternative Option to Compression Hemostasis in Case of Esophageal Vein Bleeding in Patients with Portal Hypertension

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