Self-Emulsifying Drug Delivery Systems as an Approach to Improve Therapeutic Effectiveness of Orally Administrated Drugs

Pehlivanov, Ivaylo

doi:10.5272/jimab.2019252.2575

Cited by 4 publications

(2 citation statements)

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“… Spontaneous formation  Ease of manufacture and low cost  Thermodynamic stability and improved solubilization of bioactive materials  More consistent temporal profiles of drug absorption Greater bioavailability  Less drug needs to be used  Faster release rates and improvement of the drug acceptance by consumers  Selective drug targeting toward a specific absorption window in the GI tract and  Drug protection from the hostile environment in the gut  They offer an improvement in the rate and extent of absorption and result in more reproducible blood time profiles  Lower cost. [47][48][49][50] SE Solid Dispersions: These formulations consist of a dispersion of the drug in an inert excipient matrix, but some manufacturing difficulties and stability problems existed. SE excipients have the ability to improve the absorption of drugs with poor solubility.…”

Section: Advantages Of S-smedds: 46mentioning

confidence: 99%

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2020

IJPSR

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Oral route has always been the preferred route of drug administration in many diseases. This route is limited to those drugs molecules that are permeable across the gastric mucosa and are sparingly soluble. Solubility is an important parameter to achieve the desired concentration of drug in systemic circulation for therapeutic response. As a consequence of modern drug discovery techniques, there has been a steady increase in the number of new active lipophilic compounds that are poorly water-soluble. It is a challenge for a scientist to convert those molecules into an orally administered formulation with sufficient bioavailability. Improving oral bioavailability of poorly watersoluble drugs using self micro emulsifying drug delivery systems (SMEDDS) appears most promising. Currently, various technologies are available to deal with insoluble drugs such as micronization, solid dispersions, complex formation, etc. Among the several approaches, SMEDDS has emerged as a distinctive approach used to improve the bioavailability of hydrophobic drugs. SMEDDS is isotropic mixture of drug, surfactants, cosurfactants, and oil which have unique ability to form fine o/w microemulsion on slight shaking followed by dilution with gastrointestinal fluid. In-vitro features such as concentration of surfactants, ratio of oil to surfactant, zeta potential, and size of droplet play a crucial role in drug absorption orally. The present article compiled comprehensively which gives a complete overview of SMEDDS as a promising approach to effectively tackle the problem of poorly soluble molecules. It also provides a discussion on recent developments in SMEDDS and solid SMEDDS, their characterization and applications. INTRODUCTION: As a consequence of modern drug discovery techniques, there has been a steady increase in the number of new pharmacologically active lipophilic compounds that are poorly watersoluble. About 40% of new drugs exhibit poor water solubility, resulting in lack of dose proportionality, high inter-and intra-subject variability, and low oral bioavailability.

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Section: Advantages Of S-smedds: 46mentioning

confidence: 99%

Untitled

2020

IJPSR

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“…Dissolution is the rate-limiting step for less soluble drugs, hence a small increase in dissolution rate sometimes leads to increase in the bioavailability. Formulation performance depends on the rate and extent of the drugs belonging to the Biopharmaceutical Classification System (BCS) Class II [1]. Selfemulsifying drug delivery system (SEDDS) is a lipid-based formulation and an isotropic mixture of surfactants, oil phase, co-solvents and drug that form a milky emulsion with a submicrometric droplet size following mild agitation in water or gastrointestinal fluid [2].…”

Section: Introductionmentioning

confidence: 99%