Orally administered self-emulsifying drug delivery system in disease management: advancement and patents

Mishra, Vijay; Nayak, Pallavi; Yadav, Nishika; Singh, Manvendra; Tambuwala, Murtaza M.; Aljabali, Alaa A. A.

doi:10.1080/17425247.2021.1856073

Cited by 43 publications

(24 citation statements)

References 70 publications

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“…However, most existing drugs and chemical entities have poor water solubility [28] . For the formulation of these drugs, several formulation strategies have been developed [ 32 , 33 ]. Among these, the solution is the simplest and its cost is the lowest [ 34 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

Naringenin nanocrystals for improving anti-rheumatoid arthritis activity

Zhang

Sun

Guan

et al. 2021

Asian Journal of Pharmaceutical Sciences

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Naringenin (NAR) is recognized for its anti-inflammatory activity. However, the clinical application of NAR is limited by low bioavailability, which is attributed to its poor aqueous solubility. In this study, we aimed to improve the therapeutic efficacy of NAR by formulating it into nanocrystals (NCs) via wet milling. The obtained NARNCs exhibited superior dissolution behaviors, increased cellular uptake, and enhanced transcellular diffusion relative to those of bulk NAR. Oral administration of NARNCs also significantly improved bioavailability in rats. In addition, the NARNCs effectively improved rheumatoid arthritis treatment in collagen-induced arthritic rats by reducing inflammatory cell infiltration and synovial damage. These results indicate that NARNCs provides a promising strategy for rheumatoid arthritis treatment.

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Section: Resultsmentioning

confidence: 99%

Naringenin nanocrystals for improving anti-rheumatoid arthritis activity

Zhang

Sun

Guan

et al. 2021

Asian Journal of Pharmaceutical Sciences

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“…This process reduces the droplet size of the emulsion and leads to an emulsion of nano size. The mechanism of sonication is responsible for the reduction of the droplet size (Mishra et al., 2021 ).…”

Section: Methods Of Preparation Of Seddsmentioning

confidence: 99%

Self-emulsifying drug delivery systems: a novel approach to deliver drugs

Salawi

2022

Drug Delivery

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Self-emulsifying drug delivery systems (SEDDS) are a proven method for poorly soluble substances works by increasing the solubility and bioavailability. SEDDS and isotropic mixtures, are composed of oils, surfactants, and occasionally cosolvents. The ability of these formulations and methods to produce microemulsions or fine oil-in-water (o/w) emulsions after moderate stirring and dilution by water phase along the GI tract might be a promising technique for lipophilic agents with dissolution rate-limited absorption. This review provides an outline of SEDDS's numerous advances and biopharmaceutical elements, types, manufacturing, characterization, limitations, and future prospects. The evaluation of SEDDS and its applications are also discussed, focusing on the advances of SEDDS's solid self-emulsifying delivery mechanism and dosage form. By integrating suitable polymer into the formulation, SEDDS may be studied for the creation of a formulation with sustained drug release. This technology's improvement might lead to a new application in the field of medicine delivery. SEDDS has been demonstrated to be quite efficient in increasing oral bioavailability of lipophilic products. SEDDS is one of the promising methods for controlling the characteristics of medications that are not great choices for oral delivery. It is also worth mentioning that SEDDS may be made in variety of solid dosage forms that are acceptable for both oral and parenteral administration.

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“…The poor water solubility and active chemical properties limit its application in food and pharmaceutical industries. Oral administration is the most common, ideal, and convenient route for many drugs or bioactive molecule administration [ 14 ]. To improve the bioavailability of genipin through oral administration, nanocrystals [ 15 ], cyclodextrin embedding [ 16 ], and hydrogel [ 17 ] were reported to improve its water solubility and intestinal absorption.…”

Section: Introductionmentioning

confidence: 99%

“…Lipid-based emulsion systems, including microemulsion, nanoemulsion, niosomes, SMEDDS (self microemulsifying drug delivery systems), and SNEDDS (self-nanoemulsifying drug delivery systems), have been proven to promote solubility and bioavailability, highlighting the potential value of this type of delivery approach for water-insoluble bioactive molecules [ 18 , 19 , 20 ]. Furthermore, encapsulating drugs in emulsion can also protect it from degeneration, control the release, and minimize the side effects [ 14 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Microemulsion Delivery System Improves Cellular Uptake of Genipin and Its Protective Effect against Aβ1-42-Induced PC12 Cell Cytotoxicity

Zheng

et al. 2022

Pharmaceutics

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Genipin has attracted much attention for its hepatoprotective, anti-inflammatory, and neuroprotection activities. However, poor water solubility and active chemical properties limit its application in food and pharmaceutical industries. This article aimed to develop a lipid-based microemulsion delivery system to improve the stability and bioavailability of genipin. The excipients for a genipin microemulsion (GME) preparation were screened and a pseudo-ternary phase diagram was established. The droplet size (DS), zeta potential (ZP), polydispersity index (PDI), physical and simulated gastrointestinal digestion stability, and in vitro drug release properties were characterized. Finally, the effect of the microemulsion on its cellular uptake by Caco-2 cells and the protective effect on PC12 cells were investigated. The prepared GME had a transparent appearance with a DS of 16.17 ± 0.27 nm, ZP of −8.11 ± 0.77 mV, and PDI of 0.183 ± 0.013. It exhibited good temperature, pH, ionic strength, and simulated gastrointestinal digestion stability. The in vitro release and cellular uptake data showed that the GME had a lower release rate and better bioavailability compared with that of free genipin. Interestingly, the GME showed a significantly better protective effect against amyloid-β (Aβ1-42)-induced PC12 cell cytotoxicity than that of the unencapsulated genipin. These findings suggest that the lipid-based microemulsion delivery system could serve as a promising approach to improve the application of genipin.

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Orally administered self-emulsifying drug delivery system in disease management: advancement and patents

Abstract: Please download and read the instructions before proceeding to the peer review Orally administered self-emulsifying drug delivery system in disease management: Advancement and Patents

Cited by 43 publications

References 70 publications

Naringenin nanocrystals for improving anti-rheumatoid arthritis activity

Naringenin nanocrystals for improving anti-rheumatoid arthritis activity

Self-emulsifying drug delivery systems: a novel approach to deliver drugs

Microemulsion Delivery System Improves Cellular Uptake of Genipin and Its Protective Effect against Aβ1-42-Induced PC12 Cell Cytotoxicity

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