Self-crosslinked keratin nanoparticles for pH and GSH dual responsive drug carriers

Wang, Lijuan; Du, Jinsong; Han, Xiao; Dou, Jun; Shen, Jian; Yuan, Jiang

doi:10.1080/09205063.2020.1788371

Cited by 18 publications

(7 citation statements)

References 38 publications

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“…Compared with single stimulus responsive charge reversal systems, some CR-NDDSs could consecutively respond to different stimuli in extracellular and intracellular environment of cancer cells, such as pH/GSH [ 122 , 123 ], pH/ROS [ 88 , 124 , 125 ], ROS/Near-Infrared Light [ 126 ], pH/Thermal/GSH [ 127 ], etc . These dual and multi-responsive CR-NDDSs exhibit superior antitumor effects and negligible systemic toxicity, thus have attracted extensive research attention in tumor treatment as well.…”

Section: Mechanisms Of Triggered Surface Charge Conversionmentioning

confidence: 99%

Charge reversal nano-systems for tumor therapy

Zhang

Chen

et al. 2022

J Nanobiotechnol

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Surface charge of biological and medical nanocarriers has been demonstrated to play an important role in cellular uptake. Owing to the unique physicochemical properties, charge-reversal delivery strategy has rapidly developed as a promising approach for drug delivery application, especially for cancer treatment. Charge-reversal nanocarriers are neutral/negatively charged at physiological conditions while could be triggered to positively charged by specific stimuli (i.e., pH, redox, ROS, enzyme, light or temperature) to achieve the prolonged blood circulation and enhanced tumor cellular uptake, thus to potentiate the antitumor effects of delivered therapeutic agents. In this review, we comprehensively summarized the recent advances of charge-reversal nanocarriers, including: (i) the effect of surface charge on cellular uptake; (ii) charge-conversion mechanisms responding to several specific stimuli; (iii) relation between the chemical structure and charge reversal activity; and (iv) polymeric materials that are commonly applied in the charge-reversal delivery systems. Graphical Abstract

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Section: Mechanisms Of Triggered Surface Charge Conversionmentioning

confidence: 99%

Charge reversal nano-systems for tumor therapy

Zhang

Chen

et al. 2022

J Nanobiotechnol

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“…MSNs-DOX@PDA@keratin showed good pH and GSH responsiveness, as well as selective toxicity against A549 tumor cells as opposed to normal L929 cells (Figure 8), thus representing a promising approach to promote MSN-based drug delivery [26]. In a previous paper, the same authors further deepened the production of DOXloaded human hair KPNs with high GSH and pH responsiveness [47]. As opposed to other literature reports, this work describes the preparation of KNPs from reduced human hair keratin in the presence of H 2 O 2 .…”

Section: Doxorubicin-loaded Human Hair Keratin-based Nanoparticlesmentioning

confidence: 90%

Keratin-Based Nanoparticles as Drug Delivery Carriers

Ferroni

Varchi

2021

Applied Sciences

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Keratin is a structural protein of mammalian tissues and birds, representing the principal constituent of hair, nails, skin, wool, hooves, horns, beaks, and feathers, and playing an essential role in protecting the body from external harassment. Due to its intrinsic features such as biocompatibility, biodegradability, responsiveness to specific biological environment, and physical–chemical properties, keratin has been extensively explored in the production of nanocarriers of active principles for different biomedical applications. In the present review paper, we aimed to give a literature overview of keratin-based nanoparticles produced starting from human hair, wool, and chicken feathers. Along with the chemical and structural description of keratin nanoparticles, selected in vitro and in vivo biological data are also discussed to provide a more comprehensive framework of possible fields of application of this protein. Despite the considerable number of papers describing the production and use of keratin nanoparticles as carries of anticancer and antimicrobial drugs or as hemostatic and wound healing materials, still, efforts are needed to implement keratin nanoparticles towards their clinical application.

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“…The protonation of keratin NPs resulted in a zeta potential shift from −10.8 to −9.5 mV and raised further to +5.1 mV in 50 mm GSH by breaking disulfide bonds. [105] Polydopamine (PDA)/keratin NPs exhibited a shift in their zeta potential, transitioning from −11.2 to −8.7 mV at a pH of 5. However, under conditions of pH 5 along with the presence of 10 mm GSH, the zeta potential underwent a shift to the positive realm, measuring +2.9 mV.…”

Section: Ph and Redox-responsive Nanoparticlesmentioning

confidence: 99%

Charge‐Reversible Nanoparticles: Advanced Delivery Systems for Therapy and Diagnosis

Veider,

Sanchez Armengol,

Bernkop‐Schnürch

2023

Small

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The past two decades have witnessed a rapid progress in the development of surface charge‐reversible nanoparticles (NPs) for drug delivery and diagnosis. These NPs are able to elegantly address the polycation dilemma. Converting their surface charge from negative/neutral to positive at the target site, they can substantially improve delivery of drugs and diagnostic agents. By specific stimuli like a shift in pH and redox potential, enzymes, or exogenous stimuli such as light or heat, charge reversal of NP surface can be achieved at the target site. The activated positive surface charge enhances the adhesion of NPs to target cells and facilitates cellular uptake, endosomal escape, and mitochondrial targeting. Because of these properties, the efficacy of incorporated drugs as well as the sensitivity of diagnostic agents can be essentially enhanced. Furthermore, charge‐reversible NPs are shown to overcome the biofilm formed by pathogenic bacteria and to shuttle antibiotics directly to the cell membrane of these microorganisms. In this review, the up‐to‐date design of charge‐reversible NPs and their emerging applications in drug delivery and diagnosis are highlighted.

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Self-crosslinked keratin nanoparticles for pH and GSH dual responsive drug carriers

Cited by 18 publications

References 38 publications

Charge reversal nano-systems for tumor therapy

Charge reversal nano-systems for tumor therapy

Keratin-Based Nanoparticles as Drug Delivery Carriers

Charge‐Reversible Nanoparticles: Advanced Delivery Systems for Therapy and Diagnosis

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