Keratin-Based Nanoparticles as Drug Delivery Carriers

Ferroni, Claudia; Varchi, Greta

doi:10.3390/app11209417

Cited by 30 publications

(19 citation statements)

References 74 publications

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“…Herein, as determined by the CCK-8 assay, we examined the cell viability of hydrogel extractions of different compositions when cocultured with L929 fibroblast cells. On the basis of the rapid proliferation of fibroblasts, the CCK-8 assay was repeated regularly (1, 3, and 7 d) as per previous reports. , The results in Figure a,b demonstrate that the O.D. values representing cell viability in KAPs–PEGDA (that is, KAPs/KIFs = 10/0 in the gel) and KIFs–PEGDA (that is, KAPs/KIFs = 0/10 in the gel) extracts, respectively, showing proliferation of cells increased with time.…”

Section: Resultsmentioning

confidence: 99%

Study on Keratin/PEGDA Composite Hydrogel with the Addition of Varied Hair Protein Fractions

Chen

Wang

et al. 2022

ACS Appl. Polym. Mater.

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Synthetic polymers, such as poly(ethylene glycol diacrylate) (PEGDA), may make hydrogels more quickly and efficiently; however, these systems are devoid of cell adhesion ligands. As a result, poly(ethylene glycol)-based polymers are restricted in their application to tissue engineering, whereas keratins, a biopolymer functional to the body, have been added to the PEGDA composite hydrogel to make it further applicable. However, as keratin is a mixture of proteins, a keratin-based material may have inconsistent properties due to the complicated keratin composition. This study investigates the effects of different fractions of keratin on the keratin/PEGDA composite properties. A hair was extracted and purified to identify internal keratin filaments (KIFs) and keratin-associated proteins (KAPs). The KIFs and KAPs were mixed with PEGDA to form a hydrogel by photo-cross-linking. The porosity measured in the gels was between 54% and 83%. We also determined the mechanical behavior of the composite through compression and tension tests. These analyses yielded a range of material strengths from 4.0 to 7.1 kPa and from 2.7 to 2.3 kPa, respectively. The gel properties correlated highly with the KAPs/KIFs content, as the two proteins have distinct beta structures. Modulating this ratio results in a keratin/PEGDA composite with more controllable gel properties.

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Section: Resultsmentioning

confidence: 99%

Study on Keratin/PEGDA Composite Hydrogel with the Addition of Varied Hair Protein Fractions

Chen

Wang

et al. 2022

ACS Appl. Polym. Mater.

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“…Keratin-based nanoparticles are suitable carriers for various antitumor drugs such as doxorubicin, paclitaxel, and chlorine c6 and 9(R)-9-hydroxystearic acid, and multiple polyphenols such as rutin, quercetin, and curcumin. In addition, they are also crucial for tissue engineering and wound healing [ 152 , 153 ]. Fibroin and sericin are the major proteins of silk proteins.…”

Section: Animal-based Biopolymeric Nanoparticles Used For Healthcare ...mentioning

confidence: 99%

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Kučuk

Primožič

Knez

et al. 2023

IJMS

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Biopolymeric nanoparticles are gaining importance as nanocarriers for various biomedical applications, enabling long-term and controlled release at the target site. Since they are promising delivery systems for various therapeutic agents and offer advantageous properties such as biodegradability, biocompatibility, non-toxicity, and stability compared to various toxic metal nanoparticles, we decided to provide an overview on this topic. Therefore, the review focuses on the use of biopolymeric nanoparticles of animal, plant, algal, fungal, and bacterial origin as a sustainable material for potential use as drug delivery systems. A particular focus is on the encapsulation of many different therapeutic agents categorized as bioactive compounds, drugs, antibiotics, and other antimicrobial agents, extracts, and essential oils into protein- and polysaccharide-based nanocarriers. These show promising benefits for human health, especially for successful antimicrobial and anticancer activity. The review article, divided into protein-based and polysaccharide-based biopolymeric nanoparticles and further according to the origin of the biopolymer, enables the reader to select the appropriate biopolymeric nanoparticles more easily for the incorporation of the desired component. The latest research results from the last five years in the field of the successful production of biopolymeric nanoparticles loaded with various therapeutic agents for healthcare applications are included in this review.

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“…Maleimide-modified ATRP initiators functionalize the thiol group on BSA. Such nanoaggregates have been used to deliver enzymes without affecting their catalytic activity and eliminate organic solvent use during their synthesis [ 110 ].…”

Section: Types Of Proteins Used As Micelles For Drug Deliverymentioning

confidence: 99%

Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers

et al. 2023

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Proteins-derived polymeric micelles have gained attention and revolutionized the biomedical field. Proteins are considered a favorable choice for developing micelles because of their biocompatibility, harmlessness, greater blood circulation and solubilization of poorly soluble drugs. They exhibit great potential in drug delivery systems as capable of controlled loading, distribution and function of loaded agents to the targeted sites within the body. Protein micelles successfully cross biological barriers and can be incorporated into various formulation designs employed in biomedical applications. This review emphasizes the recent advances of protein-based polymeric micelles for drug delivery to targeted sites of various diseases. Most studied protein-based micelles such as soy, gelatin, casein and collagen are discussed in detail, and their applications are highlighted. Finally, the future perspectives and forthcoming challenges for protein-based polymeric micelles have been reviewed with anticipated further advances.

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Keratin-Based Nanoparticles as Drug Delivery Carriers

Cited by 30 publications

References 74 publications

Study on Keratin/PEGDA Composite Hydrogel with the Addition of Varied Hair Protein Fractions

Study on Keratin/PEGDA Composite Hydrogel with the Addition of Varied Hair Protein Fractions

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers

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