Self‐control impacts symptoms defining Internet gaming disorder through dorsal anterior cingulate–ventral striatal pathway

Gong, Liangyu; Zhou, Hui; Su, Conghui; Geng, Fengji; Wang, Xi; Teng, Binyu; Yuan, Kai; Zhao, Min; Hu, Yuzheng

doi:10.1111/adb.13210

Cited by 7 publications

(11 citation statements)

References 78 publications

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“…72 These results indicated that the approachavoidance bias was closely associated with addiction, and would dynamically change during the different phases of addiction, and asymmetries in striatal function may serve as the potential neural substrates. Consistent with our previous finding, which displayed that only functional connectivity between rVS and dACC was negatively correlated with individuals' severity of internet gaming disorder, 12 we found that only white matter characteristics of dACC-rVS pathway correlated with individual's self-control and internet addiction severity in the current study. This result indicates that the interplay between self-control and avoidance procedure may play a dominant role in the internet addiction development.…”

Section: The Laterality Of Dacc-vs Pathway In Addictionsupporting

confidence: 93%

“…17 Our previous work has further identified dysfunctional frontostriatal circuits in substance use disorders, and a pivotal imbalance between the orbitofrontal cortex (OFC) and dACC/ prelimbic circuits in both individuals struggling with compulsive drug use and rats exhibiting addictive-like behaviour. 18,19 Moreover, we have further found that the resting-state functional connectivity between the dACC and the right ventral striatum (rVS), but not the left ventral striatum (lVS), partially mediated the relationship between self-control scores and internet addiction severity, 12 indicating the essential role that dACC-rVS pathway plays in modulating self-control and internet addiction. Despite this functional evidence highlighting the interplay between dACC, self-control, and internet addiction, the underlying structural substrates remain elusive.…”

Section: Introductionmentioning

confidence: 81%

“…Previous studies suggested that deficits in self‐control, which refers to the ability to regulate one's thoughts, emotions, and behaviours in the pursuit of long‐term goals, may play a significant role in modulating individuals' addictive behaviours. Specifically, individuals with internet addiction displayed significantly lower levels of self‐control 8,9 and a negative correlation was found between self‐control and the severity of internet addiction, 10 including its manifestations such as online game addiction, 11,12 which is a major form of internet use and has been officially included in the ICD‐11 by World Health Organization 13 . Previous studies have identified that the dorsal anterior cingulate cortex (dACC) is an essential neural substrate underlying both self‐control and addiction behaviour 14,15 .…”

Section: Introductionmentioning

confidence: 99%

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White matter integrity of right frontostriatal circuit predicts internet addiction severity among internet gamers

Zhou,

Gong,

et al. 2024

Addiction Biology

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Excessive use of the internet, which is a typical scenario of self‐control failure, could lead to potential consequences such as anxiety, depression, and diminished academic performance. However, the underlying neuropsychological mechanisms remain poorly understood. This study aims to investigate the structural basis of self‐control and internet addiction. In a cohort of 96 internet gamers, we examined the relationships among grey matter volume and white matter integrity within the frontostriatal circuits and internet addiction severity, as well as self‐control measures. The results showed a significant and negative correlation between dACC grey matter volume and internet addiction severity (p < 0.001), but not with self‐control. Subsequent tractography from the dACC to the bilateral ventral striatum (VS) was conducted. The fractional anisotropy (FA) and radial diffusivity of dACC‐right VS pathway was negatively (p = 0.011) and positively (p = 0.020) correlated with internet addiction severity, respectively, and the FA was also positively correlated with self‐control (p = 0.036). These associations were not observed for the dACC‐left VS pathway. Further mediation analysis demonstrated a significant complete mediation effect of self‐control on the relationship between FA of the dACC‐right VS pathway and internet addiction severity. Our findings suggest that the dACC‐right VS pathway is a critical neural substrate for both internet addiction and self‐control. Deficits in this pathway may lead to impaired self‐regulation over internet usage, exacerbating the severity of internet addiction.

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Section: The Laterality Of Dacc-vs Pathway In Addictionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

White matter integrity of right frontostriatal circuit predicts internet addiction severity among internet gamers

Zhou,

Gong,

et al. 2024

Addiction Biology

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“…IGD severity has also been associated with VS bias for monetary rewards [ 95 ], and has been negatively associated with FC between frontal and striatal brain areas [ 96 ]. Furthermore, the number of IGD symptoms appears to be negatively associated with dorsal-ACC-VS resting-state FC, suggesting that it may be considered as a biomarker of IGD, as well as an important target for interventions addressing this disorder [ 97 ]. The functional coupling between dorsal ACC and VS may be involved in feedback learning.…”

Section: Resultsmentioning

confidence: 99%

Potential Biological Markers and Treatment Implications for Binge Eating Disorder and Behavioral Addictions

Mestre‐Bach

Potenza

2023

Nutrients

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The reward system is highly relevant to behavioral addictions such as gambling disorder (GD), internet gaming disorder (IGD), and food addiction/binge eating disorder (FA/BED). Among other brain regions, the ventral striatum (VS) has been implicated in reward processing. The main objective of the present state-of-the-art review was to explore in depth the specific role of the VS in GD, IGD and FA/BED, understanding it as a possible biomarker of these conditions. Studies analyzing brain changes following interventions for these disorders, and especially those that had explored possible treatment-related changes in VS, are discussed. More evidence is needed on how existing treatments (both pharmacological and psychobehavioral) for behavioral addictions affect the activation of the VS and related circuitry.

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“…For the psychologic mechanism of addiction, previous studies have highlighted self-control and mindful awareness as two factors that potentially modulate addictive behaviors (15)(16)(17). Self-control refers to the ability to regulate one's thoughts, emotions, and behaviors in the pursuit of long-term goals.…”

Section: Introductionmentioning

confidence: 99%

Glutamate Concentration of Medial Prefrontal Cortex is Inversely Associated with Addictive Behaviors: A Translational Study

Yang,

Zhou,

Hong

et al. 2024

Preprint

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In both preclinical and clinical settings, dysregulated frontostriatal circuits have been identified as the underlying neural substrates of compulsive seeking/taking behaviors manifested in substance use disorders and behavioral addictions including internet gaming disorder (IGD). However, the neurochemical substrates for these disorders remain elusive. The lack of comprehensive cognitive assessments in animal models has hampered our understanding of neural plasticity in addiction from these models. In this study, combining data from a rat model of compulsive taking/seeking and human participants with various levels of IGD severity, we investigated the relationship between regional glutamate (Glu) concentration and addictive behaviors. We found that Glu levels were significantly lower in the prelimbic cortex (PrL) of rats after 20-days of methamphetamine self-administration (SA), compared to controls. Glu concentration after a punishment phase negatively correlated with acute drug-seeking behavior. In addition, changes in Glu levels from a drug naïve state to compulsive drug taking patterns negatively correlated with drug-seeking during both acute and prolonged abstinence. The human data revealed a significant negative correlation between Glu concentration in the dorsal anterior cingulate cortex (dACC), the human PrL counterpart, and symptoms of IGD. Interestingly, there was a positive correlation between Glu levels in the dACC and self-control, as well as mindful awareness. Further analysis revealed that the dACC Glu concentration mediated the relationship between self-control/mindful awareness and IGD symptoms. These results provide convergent evidence for a protective role of dACC/PrL in addiction, suggesting interventions to enhance dACC glutamatergic functions as a potential strategy for addiction prevention and treatment.

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Self‐control impacts symptoms defining Internet gaming disorder through dorsal anterior cingulate–ventral striatal pathway

Cited by 7 publications

References 78 publications

White matter integrity of right frontostriatal circuit predicts internet addiction severity among internet gamers

White matter integrity of right frontostriatal circuit predicts internet addiction severity among internet gamers

Potential Biological Markers and Treatment Implications for Binge Eating Disorder and Behavioral Addictions

Glutamate Concentration of Medial Prefrontal Cortex is Inversely Associated with Addictive Behaviors: A Translational Study

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