Glutamate Concentration of Medial Prefrontal Cortex is Inversely Associated with Addictive Behaviors: A Translational Study
Yihong Yang,
Hui Zhou,
Tiantian Hong
et al.
Abstract:In both preclinical and clinical settings, dysregulated frontostriatal circuits have been identified as the underlying neural substrates of compulsive seeking/taking behaviors manifested in substance use disorders and behavioral addictions including internet gaming disorder (IGD). However, the neurochemical substrates for these disorders remain elusive. The lack of comprehensive cognitive assessments in animal models has hampered our understanding of neural plasticity in addiction from these models. In this s… Show more
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