Abstract. We calculate mass shift of the J/Ψ meson in nuclear matter arising from the modification of DD, DD * and D * D * meson loop contributions to the J/Ψ self-energy. The estimate includes the in-medium D and D * meson masses consistently. The J/Ψ mass shift (scalar potential) calculated is negative (attractive), and complementary to the attractive potential obtained from the QCD color van der Waals forces. Some results for the J/Ψ-nuclear bound state energies are also presented.Keywords: J/Ψ-nuclear bound state, in-medium J/Ψ self-energy, Quark-meson coupling model PACS: 21.85.+d,21.65Jk,21.65.Qr,24.85.+P