This research to describe the influence of the Big Five personality traits on self-compassion in adolescents. This research uses a quantitative method. The subjects in this study were 400 students Senior High School in D.I. Yogyakarta. Measuring instruments used are Self Compassion Scale (SCS) and IPIP-BFM-50. Data analysis uses multiple regression with significance (p) < 0,05. The result shows the significant influence of the big five personality traits together on self-compassion in adolescents (p = 0,000). The analysis also revealed that there was influence each big five personality traits on self-compassion, namely; extraversion (p = 0,026), agreeableness (p = 0,003), conscientiousness (p = 0,000), emotional stability (p = 0,000), and intellect (P = 0,709). Based on multiple regression analysis extraversion, agreeableness, conscientiousness, and emotional stability as the predictors of self-compassion in adolescents significantly, whereas intellect personality trait is not significant to be a predictor of self-compassion.