Self-cascade nanohybrids boost cell ferroptosis stress for tumor radiosensitization therapy

Ultrasmall MnOx Nanodots Catalyze Glucose for Reactive Oxygen Species‐Dependent Sequential Anti‐Infection and Regeneration Therapy

“…Synthesis and Characterizations of BM-NDs: BSA-coated MnO x nanodots with different valence states of Mn were prepared according to our previous study with minor modifications. [19] Briefly, the pH value of BSA solutions (250 mg, 5 mL) was adjusted to 5.5, 7.0, and 8.5 using Na 2 CO 3 /HCl, followed by the dropwise addition of KMnO 4 (400 μL, 100 mM), and the solutions were continuously stirred (500 rpm) for 2 h at 37 °C using a magnetic heating agitator (DLAB, China). After being purified by the ultrafiltration (MWCO = 100 K), the products were lyophilized for subsequent characterizations and usages.…”

“…[ 18 ] In our recent work, we have developed Mn‐based nanohybrids with “four‐in‐one” enzyme‐mimicking activities that are capable of self‐supplying H 2 O 2 and generating ·OH and oxygen, while simultaneously depleting intracellular glutathione (GSH), ultimately inducing ferroptosis of tumor cells. [ 19 ] Notably, the ultrasmall MnO x nanodots exhibit glucose oxidase (GOx)‐mimicking properties, enabling the efficient consumption of glucose. [ 19 ] This unique property of the MnO x nanodots makes them particularly well‐suited for use in diabetic wound microenvironments, where they could potentially function as a glucose‐driven therapeutic agent.…”

Cascade strategy for glucose oxidase-based synergistic cancer therapy using nanomaterials

“…With the exogenous H 2 O 2 furnished by GOx, OH generated by the reduction of H 2 O 2 by radiation-generated electrons could cooperate with ROS generated by semiconductor heterojunctions, manifesting a more potent efficacy at lower radiation doses. More recently, considering the intriguing radiosensitization of Au and CAT/GOx-mimicking activity of ultrafine MnO 2 nanosheets, Wu et al 251 employed Au nanoclusters coated with BSA (BSA@Au, BA) to conjugate with Mn-based nanoparticles of ultrasmall size. Meanwhile, the researchers radioactively labeled the Au nanocluster core with 64 Cu to achieve positron emission tomography imaging, ultimately designing a selfcascade nanozyme (BAM) (Fig.…”

The rational design of nanozymes for imaging-monitored cancer therapy

“…A four-in-one self-cascade nanohybrid with POD, CAT, and GPx-like enzyme-like activities was applied to boost ferroptosis stress for tumor therapy. 114 This nanozyme was fabricated with MnO 2 nanodots, bovine serum albumin, and Au nanoclusters. Ferroptosis stress was enhanced due to the hypoxia relief (O 2 generation through a CAT-like process), oxidation of lipids (ROS generated from a POD-like process), and GSH depletion (GPx-like process).…”