1989
DOI: 10.1002/jps.2600780204
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Self-Association and Solubility Behaviors of a Novel Anticancer Agent, Brequinar Sodium

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Cited by 25 publications
(11 citation statements)
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“…It should be noted that not all surface-active molecules or ions form micelles [16]. This behavior has also been evidenced with some drugs that are shown to be surface active, but do not form micelles [17]. This work highlights that not all surface-active molecules form micelles.…”
Section: Surface Characteristics Of Surfactant and Preservative Aqueosupporting
confidence: 64%
“…It should be noted that not all surface-active molecules or ions form micelles [16]. This behavior has also been evidenced with some drugs that are shown to be surface active, but do not form micelles [17]. This work highlights that not all surface-active molecules form micelles.…”
Section: Surface Characteristics Of Surfactant and Preservative Aqueosupporting
confidence: 64%
“…This method has been used to determine critical association concentrations of other aromatic drugs 15,16 and is briefly described here. In the limit of an infinitely dilute solution, the cromolyn molecules exist predominantly as solvated monomers and the NMR resonances occur at corresponding values, d m .…”
mentioning
confidence: 99%
“…As both 13 C and 1 H at position 6 showed significant spectral shifts, the chemical shift of this proton, H6, was chosen as an indicator for self‐association of cromolyn molecules in D 2 O. This method has been used to determine critical association concentrations of other aromatic drugs15,16 and is briefly described here. In the limit of an infinitely dilute solution, the cromolyn molecules exist predominantly as solvated monomers and the NMR resonances occur at corresponding values, δ m .…”
Section: Resultsmentioning
confidence: 99%