2014
DOI: 10.1021/la5031262
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Self-Assembly Thermodynamics of pH-Responsive Amino-Acid-Based Polymers with a Nonionic Surfactant

Abstract: The behavior of pH-responsive polymers poly(N-methacryloyl-l-valine) (P1), poly(N-methacryloyl-l-phenylalanine) (P2), and poly(N-methacryloylglycyne-l-leucine) (P3) has been studied in the presence of the nonionic surfactant Brij98. The pure polymers phase-separate in an acidic medium with critical pHtr values of 3.7, 5.5, and 3.4, respectively. The addition of the surfactant prevents phase separation and promotes reorganization of polymer molecules. The nature of the interaction between polymer and surfactant… Show more

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Cited by 15 publications
(9 citation statements)
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References 81 publications
(133 reference statements)
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“…A versatile trigger to achieve structural control over the self‐assembled nanoparticles is pH; for instance, building blocks with pH‐dependent molecular structure can be used . Recently, we have introduced a concept of electrostatic self‐assembly relying on a general combination of interactions leading to the synthesis of well‐defined supramolecular nanoscale assemblies .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…A versatile trigger to achieve structural control over the self‐assembled nanoparticles is pH; for instance, building blocks with pH‐dependent molecular structure can be used . Recently, we have introduced a concept of electrostatic self‐assembly relying on a general combination of interactions leading to the synthesis of well‐defined supramolecular nanoscale assemblies .…”
Section: Introductionmentioning
confidence: 99%
“…
particular with regard to newer concepts for self-assembly.A versatile trigger to achieve structural control over the self-assembled nanoparticles is pH; for instance, building blocks with pH-dependent molecular structure can be used. [12][13][14][15][16] Recently, we have introduced a concept of electrostatic self-assembly relying on a general combination of interactions leading to the synthesis of well-defined supramolecular nanoscale assemblies. [17] The process is based on the self-assembly of polyelectrolytes and organic counterions and results in electrostatically stabilized nanoparticles with sizes up to more than hundred nanometers.
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mentioning
confidence: 99%
“…In addition, particles with triggerable size and shape are of special interest for drug delivery. For example, the circulation lifetime of intravenously administered nanoparticles has been demonstrated to depend on their dimension and shape. Among others, pH variation is commonly used as a trigger for size and shape. In this context, we have recently introduced the concept of electrostatic self-assembly for the formation of responsive supramolecular nanoscale assemblies. The process is based on the interconnection of dendrimeric macroions and oppositely charged multivalent azo dyes under secondary interaction effects such as π–π stacking or geometric factors and leads to the formation of nanoparticles with sizes up to more than 100 nm. , The process relies on a general combination of interactions rather than on specific binding motifs. Choosing appropriate building blocks, switchable nanoparticles that respond to light and pH have been built. ,, An assembly with on–off switchability through pH is realized via protonation and deprotonation of the polyelectrolyte, that is, charging and uncharging the dendrimer macroions.…”
Section: Introductionmentioning
confidence: 99%
“…FTIR (cm −1 ) (Figure S2C): 3300, ν N−H (amide); 1692, ν CO (carbamate); 1657, ν CO (amide I); 1520, ν CO (amide II); 1394, ν C−N (amide). 1 H NMR (400 MHz, CD 3 OD, TMS) δ (ppm) (Figure S9): 1.42 (s, 9H, "h"), 4.0 (br s, 1H), 1.75 (br s, 2H, "g"), 1.61 (br s, 2H, "f"), 1.52 (br s, 2H, "d"), 3.0 (br s, 2H, "e"), 2.0 (br s, 2H, "a"), and 1.51 (br s, 1H, "b"). 13 C NMR (100 MHz, CD 3 OD, TMS) δ (ppm) (Figure S10): 23.1 (methylene, "f"), 28.2 (methyl, "l"), 28.7 (methylene, "e"), 30.7 (methylene, "g"), 40.3 (methylene, "d"), 55.5 (methyne, "h"), 80.8 (tertiary, "k"), 31.5 (methylene, "a"), 42.7 (methyne, "b"), 158.5 (carbamate, "j"), 177.3 (amide, "c"), and 178.6 (carboxyl, "i").…”
Section: ■ Experimental Sectionmentioning
confidence: 99%