Self‐Assembly of Wireframe DNA Nanostructures from Junction Motifs

Huang, Kai; Yang, Donglei; Tan, Zhenyu; Chen, Silian; Xiang, Ye; Mi, Yongli; Mao, Chengde; Wei, Bryan

doi:10.1002/ange.201906408

Cited by 9 publications

(2 citation statements)

References 37 publications

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“…The above results indicated the gradual opening of the parallelly and closely aligned core arms in the H-shaped longitudinal weaving architecture to form the X-shaped bLW xbp tiles with increasing the bridging length, correspondingly. All the bLW xbp -O tubes possess similar diameters in the range of 55.0 to 65.0 nm (Figures S11,14,17,and 20), probably due to the similar overall curvature remained after the counteraction among the face-alternating tiles.…”

Section: Chemistry-a European Journalmentioning

confidence: 91%

“…Rationally, point‐star‐O tiles should be easily deduced from the traditional point‐star‐E tiles because both lengths of an even number and an odd number of half‐turns have been extensively used in DNA nanotechnology to keep planarity of 2D DNA arrays. However, point‐star‐O tiles have been reported only recently, [13,14] nearly 20 years later than the first report of the traditional point‐star‐E tiles [5a] . Point‐star tile cores have the shape of concave polygons.…”

Section: Introductionmentioning

confidence: 99%

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Tuning the Roundabout of Four‐Point‐Star Tiles with the Core Arm Length of Three Half‐Turns for 2D DNA Arrays

Wang

et al. 2022

Chemistry A European J

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By rationally adjusting the weaving modes of point‐star tiles, the curvature inherent in the tiles can be changed, and various DNA nanostructures can be assembled, such as planar wireframe meshes, perforated wireframe tubes, and curved wireframe polyhedra. Based on the weaving and tiling architectures for traditional point‐star tiles with the core arm length at two DNA half‐turns, we improved the weaving modes of our newly reported four‐point‐star tiles with the core arm length at three half‐turns to adjust their curvature and rigidity for assembling 2D arrays of DNA grids and tubes. Following our previous terms and methods to analyze the structural details of E‐tiling tubes, we used the chiral indices (n,m) to describe the most abundant tube of typical assemblies; especially, we applied both one‐locus and/or dual‐locus biotin/streptavidin (SA) labelling strategies to define the configurations of two specific tubes, along with the absolute conformations of their component tiles. Such structural details of the DNA tubes composed of tiles with addressable concave and convex faces and packing directions should help us understand their physio‐chemical and biological properties, and therefore promote their applications in drug delivery, biocatalysis, biomedicine, etc.

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Section: Chemistry-a European Journalmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Tuning the Roundabout of Four‐Point‐Star Tiles with the Core Arm Length of Three Half‐Turns for 2D DNA Arrays

Wang

et al. 2022

Chemistry A European J

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Programming the Nucleation of DNA Brick Self‐Assembly with a Seeding Strand

et al. 2020

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Recently, the DNA brick strategy has provided a highly modular and scalable approach for the construction of complex structures, which can be used as nanoscale pegboards for the precise organization of molecules and nanoparticles for many applications. Despite the dramatic increase of structural complexity provided by the DNA brick method, the assembly pathways are still poorly understood. Herein, we introduce a “seed” strand to control the crucial nucleation and assembly pathway in DNA brick assembly. Through experimental studies and computer simulations, we successfully demonstrate that the regulation of the assembly pathways through seeded growth can accelerate the assembly kinetics and increase the optimal temperature by circa 4–7 °C for isothermal assembly. By improving our understanding of the assembly pathways, we provide new guidelines for the design of programmable pathways to improve the self‐assembly of DNA nanostructures.

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Sequence‐Dependent DNA Functionalization of Upconversion Nanoparticles and Their Programmable Assemblies

Wang

Pan

et al. 2020

Angewandte Chemie

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DNA-modified lanthanide-doped upconversion nanoparticles (DNA-UCNPs) that combine the functions of DNA and the optical features of UCNPs have shown great promise in a wide range of fields. However, challenges remain in precisely tethering and orienting the DNA strands on the UCNP surface. Herein, we systematically investigate the sequence dependence of DNAs in their interactions with UCNPs, and reveal that poly-cytosine (poly-C) has high affinity for the UCNP surface. A general approach to synthesize monodispersed DNA-UCNP conjugates is developed using poly-C-containing diblock DNA strands. The poly-C segment of the DNA strand binds to the surfaces of UCNPs and the second segment is oriented perpendicularly on the UCNP surface, making the DNA-UCNPs highly stable and monodispersed in aqueous solution. The dense layer of DNA on the UCNP surface enables the programmable assembly of UCNPs with other DNA-functionalized nanoparticles or DNA origamis through hybridization, resulting in the formation of well-organized complex structures.

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Self‐Assembly of Wireframe DNA Nanostructures from Junction Motifs

Cited by 9 publications

References 37 publications

Tuning the Roundabout of Four‐Point‐Star Tiles with the Core Arm Length of Three Half‐Turns for 2D DNA Arrays

Tuning the Roundabout of Four‐Point‐Star Tiles with the Core Arm Length of Three Half‐Turns for 2D DNA Arrays

Programming the Nucleation of DNA Brick Self‐Assembly with a Seeding Strand

Sequence‐Dependent DNA Functionalization of Upconversion Nanoparticles and Their Programmable Assemblies

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