Self-assembly of drug-loaded liposomes on genetically engineered protein nanotubes: a potential anti-cancer drug delivery vector

Ngweniform, Pascaline; Liu, Dong; Mao, Chuanbin

doi:10.1039/b817863a

Cited by 26 publications

(21 citation statements)

References 20 publications

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“…Biological templates not only guide the nucleation of inorganic materials, but also control the crystal structure and size, under aqueous and ambient conditions. The bionic approaches to the synthesis of nanocrystals can also be extended to living biological systems (Anshup et al, 2005; Du et al, 2007; Mao et al, 2003; Yoo et al, 2006), which are ideal nano-structured templates for the design and synthesis of nanomaterials because of their endogenous ability of molecular recognition and self-assembly (Huang et al, 2005; Ngweniform et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and characterization of CdS quantum dots in genetically engineered Escherichia coli

Wang

Zhang

et al. 2011

Journal of Biotechnology

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Quantum dots (QDs) were prepared in genetically engineered Escherichia coli (E. coli) through the introduction of foreign genes encoding a CdS binding peptide. The CdS QDs were successfully separated from the bacteria through two methods, lysis and freezing–thawing of cells, and purified with an anion-exchange resin. High-resolution transmission electron microscopy, X-ray diffraction, luminescence spectroscopy, and energy dispersive X-ray spectroscopy were applied to characterize the as-prepared CdS QDs. The effects of reactant concentrations, bacteria incubation times, and reaction times on QD growth were systematically investigated. Our work demonstrates that genetically engineered bacteria can be used to synthesize QDs. The biologically synthesized QDs are expected to be more biocompatible probes in bio-labeling and imaging.

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Section: Introductionmentioning

confidence: 99%

Biosynthesis and characterization of CdS quantum dots in genetically engineered Escherichia coli

Wang

Zhang

et al. 2011

Journal of Biotechnology

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“…[1] It combines nontoxic photo-sensitizer (PS), harmless visible light, and cell- and tissue-associated oxygen to generate cytotoxic reactive oxygen species (ROS) such as singlet oxygen ( 1 O 2 ). The resultant ROS kills malignant cancer cells by apoptosis and/or necrosis, shuts down the vasculature in tumors, and stimulates the host immune system, and as a result, to inhibit tumor growth and destruct tumors.…”

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confidence: 99%

Stem Cells Loaded with Nanoparticles as a Drug Carrier for In Vivo Breast Cancer Therapy

et al. 2014

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A novel anti‐cancer drug carrier, mesenchymal stem cells (MSCs) encapsulating drug‐loaded hollow silica nanoparticles, is used to carry a photosensitizer drug and deliver it to breast tumors, due to the natural high tumor affinity of the MSCs, and inhibit tumor growth by photo dynamic therapy. This new strategy for delivering a photo sensitizer to tumors by using tumor‐affinitive MSCs addresses the challenge of the accumulation of photosensitizer drugs in tumors in photodynamic therapy.

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“…Fluorescence quantum yield of the liposome entrapped ZnNC in the absence and presence of engineered phage (L/P=2.2) determined as per standard procedures (36) was found to be 0.072 and 0.076, respectively. An increase in the quantum yield of ZnNC due to the formation of phage-liposome complex can be attributed to radiationless relaxation and resonance energy transfer between engineered phage and ZnNC, making phage-liposome complex an ideal vehicle for phototherapeutics (45). …”

Section: Resultsmentioning

confidence: 99%

Architectonics of Phage-Liposome Nanowebs as Optimized Photosensitizer Vehicles for Photodynamic Cancer Therapy

Janardhanan

Narayan

Abbineni

et al. 2010

Molecular Cancer Therapeutics

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Filamentous M13 phage can be engineered to display cancer cell-targeting or tumor-homing peptides through phage display. It would be highly desirable if the tumor-targeting phage can also carry anticancer drugs to deliver them to the cancer cells. We studied the evolution of structures of the complexes between anionic filamentous M13 phage and cationic serum-stable liposomes that encapsulate the monomeric photosensitizer zinc naphthalocyanine. At specific phage-liposome ratios, multiple phage nanofibers and liposomes are interwoven into a "nanoweb." The chemical and biological properties of the phage-liposome nanoweb were evaluated for possible application in drug delivery. This study highlights the ability of phage-liposome nanowebs to serve as efficient carriers in the transport of photosensitizers to cancer cells.Mol Cancer Ther; 9(9); 2524-35. ©2010 AACR.

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Self-assembly of drug-loaded liposomes on genetically engineered protein nanotubes: a potential anti-cancer drug delivery vector

Cited by 26 publications

References 20 publications

Biosynthesis and characterization of CdS quantum dots in genetically engineered Escherichia coli

Biosynthesis and characterization of CdS quantum dots in genetically engineered Escherichia coli

Stem Cells Loaded with Nanoparticles as a Drug Carrier for In Vivo Breast Cancer Therapy

Architectonics of Phage-Liposome Nanowebs as Optimized Photosensitizer Vehicles for Photodynamic Cancer Therapy

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