Architectonics of Phage-Liposome Nanowebs as Optimized Photosensitizer Vehicles for Photodynamic Cancer Therapy

Janardhanan, Sreeram Kalarical; Narayan, Shoba; Abbineni, Gopal; Hayhurst, Andrew; Mao, Chuanbin

doi:10.1158/1535-7163.mct-10-0253

Cited by 37 publications

(16 citation statements)

References 49 publications

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“…Our group has recently developed a novel non-viral vector that mimics the structure of viruses to achieve a high transfection efficiency and sustained gene expression by means of phage-displayed cell-targeting peptides 56 57 . We will use phage display to select tumor-targeting peptides and integrate these peptides into the virus-like vector 56 58 59 to deliver ING4 gene to osteosarcoma in the future studies.…”

Section: Discussionmentioning

confidence: 99%

Delivery of inhibitor of growth 4 (ING4) gene significantly inhibits proliferation and invasion and promotes apoptosis of human osteosarcoma cells

Zhu

Zhang

et al. 2014

Sci Rep

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Growing evidence has suggested that inhibitor of growth 4 (ING4), a novel member of ING family proteins, plays a critical role in the development and progression of different tumors via multiple pathways. However, the function of ING4 in human osteosarcoma remains unclear. To understand its potential roles and mechanisms in inhibiting osteosarcoma, we constructed an expression vector pEGFP-ING4 and transfected the human osteosarcoma cells using this vector. We then studied the effects of over-expressed ING4 in the transfected cells on the proliferation, apoptosis and invasion of the osteosarcoma cells. The up-regulation of ING4 in the osteosarcoma cells, arising from the stable pEGFP-ING4 gene transfection, was found to significantly inhibit the cell proliferation by the cell cycle alteration with S phase reduction and G0/G1 phase arrest, induce cell apoptosis via the activation of the mitochondria pathway, and suppress cell invasion through the down-regulation of the matrix metalloproteinase 2 (MMP-2) and MMP-9 expression. In addition, increased ING4 level evoked the blockade of NF-κB signaling pathway and down-regulation of its target proteins. Our work suggests that ING4 can suppress osteosarcoma progression through signaling pathways such as mitochondria pathway and NF-κB signaling pathway and ING4 gene therapy is a promising approach to treating osteosarcoma.

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Section: Discussionmentioning

confidence: 99%

Delivery of inhibitor of growth 4 (ING4) gene significantly inhibits proliferation and invasion and promotes apoptosis of human osteosarcoma cells

Zhu

Zhang

et al. 2014

Sci Rep

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“…It is a rising oncologic therapeutic modality with specific spatiotemporal control and selectivity. [128] PDT generally requires three key components: photosensitizers, excitation light, and oxygen molecules. [129] Compared with typical cancer treatments including surgery, radiotherapy and chemotherapy, the main advantage of PDT is its inherent safety in the absence of light, no drug resistance, repeated treatment and minimal invasiveness.…”

Section: Electrospun Nanofibers For Photodynamic Therapymentioning

confidence: 99%

“…Electrospun nanofibers for cancer PDT can achieve considerable selective therapeutic effect by simply focusing the light on the scaffold-localized tumor region. [128a, 136] Severyukhina et al . reported a type of photosensitizer-loaded electrospun fibers for photodynamic cancer therapy.…”

Section: Electrospun Nanofibers For Photodynamic Therapymentioning

confidence: 99%

Multifunctional Electrospun Nanofibers for Enhancing Localized Cancer Treatment

Ren

et al. 2018

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Localized cancer treatment is one of the most effective strategies in clinical destruction of solid tumors at early stages as it can minimize the side effects of cancer therapeutics. Electrospun nanofibers have been demonstrated as a promising implantable platform in localized cancer treatment, enabling the on-site delivery of therapeutic components and minimizing side effects to normal tissues. This Review discusses the recent cutting-edge research with regard to electrospun nanofibers used for various therapeutic approaches, including gene therapy, chemotherapy, photodynamic therapy, thermal therapy, and combination therapy, in enhancing localized cancer treatment. Furthermore, it extensively analyzes the current challenges and potential breakthroughs in utilizing this novel platform for clinical transition in localized cancer treatment.

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“…Filamentous phage increasingly attracts scientists' attention in recent years because of its wide usage in many fields. For example, it can act as a template for nanomaterials formation, as a probe for sensing and imaging, as a vector for targeted drug and gene delivery, as a platform for screening peptides or antibodies, and as a scaffold for inducing stem cell differentiation and bone formation …”

Section: Introductionmentioning

confidence: 99%

Genetically Engineered Virus Nanofibers as an Efficient Vaccine for Preventing Fungal Infection

Huai

Dong

Zhu

et al. 2016

Adv Healthcare Materials

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Candida albicans (CA) is a kind of fungi that can cause high morbidity and mortality in immunocompromised patients. However, preventing CA infection in these patients is still a daunting challenge. Herein, inspired from the fact that immunization with Secreted aspartyl proteinases 2 (Sap2) could prevent the infection, we propose to use filamentous phage, a human-safe virus nanofiber specifically infecting bacteria (~900 nm long and 7 nm wide), to display an epitope peptide of Sap2 (EPS, with a sequence of Val-Lys-Tyr-Thr-Ser) on its side wall and thus serve as a vaccine for preventing CA infection. The engineered virus nanofibers and recombinant Sap2 (rSap2) are then separately used to immunize mice. The humoral and cellular immune responses in the immunized mice are evaluated. Surprisingly, the virus nanofibers significantly induce mice to produce strong immune response as rSap2 and generate antibodies that can bind Sap2 and CA to inhibit the CA infection. Consequently, immunization with the virus nanofibers in mice dramatically increase the survival rate of CA-infected mice. All these results, along with the fact that the virus nanofibers can be mass-produced by infecting bacteria cost-effectively, suggest that virus nanofibers displaying EPS can be a vaccine candidate against fungal infection.

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Architectonics of Phage-Liposome Nanowebs as Optimized Photosensitizer Vehicles for Photodynamic Cancer Therapy

Cited by 37 publications

References 49 publications

Delivery of inhibitor of growth 4 (ING4) gene significantly inhibits proliferation and invasion and promotes apoptosis of human osteosarcoma cells

Delivery of inhibitor of growth 4 (ING4) gene significantly inhibits proliferation and invasion and promotes apoptosis of human osteosarcoma cells

Multifunctional Electrospun Nanofibers for Enhancing Localized Cancer Treatment

Genetically Engineered Virus Nanofibers as an Efficient Vaccine for Preventing Fungal Infection

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