Self-assembly of chiral supra-amphiphiles

Ouyang, Guanghui; Liu, Minghua

doi:10.1039/c9qm00571d

Cited by 40 publications

(76 citation statements)

References 114 publications

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“…These results suggest that chirality of the molecules plays crucial role in determining thermodynamic stability and properties of chiral gels. 2,264,357 Other biomolecules like sugars can also be used to tailor gel to gel transitions. Mahendar et al synthesized a hydrazone coupled phenylboronic acid-based chiral gelator.…”

Section: (Vii) Post Assembly Fabrication Of Gels By Chemical Analytesmentioning

confidence: 99%

Stimuli responsive dynamic transformations in supramolecular gels

2021

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Section: (Vii) Post Assembly Fabrication Of Gels By Chemical Analytesmentioning

confidence: 99%

Stimuli responsive dynamic transformations in supramolecular gels

2021

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“…[30] The guest complex 16 consists of a terpyridine group as a chelating ligand that forms a coordinate with lanthanide ions (Ln 3+ = Tb 3+ , Eu 3+ ). The self-assembled 1D nanofiber based on cucurbit [8]uril (CB [8])-mediated ternary complex with terpyridine derivative (16) associates laterally with the 2D nanosheet by adding azobenzene quaternary ammonium salt (17). Peaks associated with the aromatic protons of CB[8]-16 and 16 were observed in 1 H NMR, and TEM images revealed the presence of wire-like nanofibers several hundred nanometers in length and 15 nm in width.…”

Section: Biological Applications Of Supramolecular 2d Materialsmentioning

confidence: 99%

“…Among diverse self‐assembling modules, aromatic amphiphiles can serve as remarkable candidates for the creation of well‐defined supramolecular 2D structures owing to their rigidity and the π–π stacking of aromatic groups. [ 15–17 ] In self‐assembled 2D structures composed of aromatic amphiphiles, the rigid aromatic segments surrounded by hydrophilic flexible chains can form relatively stable noncovalent interactions in a preferred direction. [ 18 ] Besides, the packing arrangements of aromatic segments can reversibly transform into a different equilibrium state when subjected to subtle environmental changes, demonstrating a distinct adaptive capability of dynamic shape alterations.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Two‐Dimensional Systems and Their Biological Applications

et al. 2020

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the construction of functional 2D materials by the self-assembly of synthetic building blocks such as amphiphilic block copolymers, [10] lipid molecules, [11] deoxyribonucleic acids (DNAs), [12] rod-coil amphiphiles, [13] and oligopeptides. [14] Among diverse self-assembling modules, aromatic amphiphiles can serve as remarkable candidates for the creation of well-defined supramolecular 2D structures owing to their rigidity and the π-π stacking of aromatic groups. [15-17] In self-assembled 2D structures composed of aromatic amphiphiles, the rigid aromatic segments surrounded by hydrophilic flexible chains can form relatively stable noncovalent interactions in a preferred direction. [18] Besides, the packing arrangements of aromatic segments can reversibly transform into a different equilibrium state when subjected to subtle environmental changes, demonstrating a distinct adaptive capability of dynamic shape alterations. [19] Therefore, the supramolecular 2D materials formed by aromatic amphiphiles hold promise in biological applications because the physical and chemical properties of the supramolecular 2D structure, which are attributed to the large surface area of these materials, can enhance the detection sensitivity of target molecules and increase the molecular loading and bio-conjugation efficiency. Furthermore, the flexibility, low toxicity, dispersibility, and permeability offered by 2D materials can contribute to the development of the next generation of functional materials in biological systems. [20-25] In this regard, several types of studies have been conducted on supramolecular 2D materials with biological applicability because supramolecular systems are more convenient for the fabrication of materials with multiple functionalities for biology applications. [26-34] Herein, we summarize supramolecular 2D materials based on the corresponding aromatic amphiphiles and discuss several of their biological applications (Figure 1). We classified the strategies of self-assembly of the 2D structure as follows: direct assembly of monomers and assembly in a stepwise manner via primary structures. In the direct assembly strategy, the aromatic amphiphilic blocks are assembled into 2D structures without transition into an intermediate state, in which the monomers are directly arranged in parallel, zigzag, or hexagonal conformations through hydrophobic, hostguest, and electrostatic interactions. However, in the stepwise assembly strategy, the monomers are assembled into primary structures such as dimeric micelles and fibers in the initial state, which is followed by lateral interactions to 2D structures. Various biological systems rely on the supramolecular assembly of biomolecules through noncovalent bonds for performing sophisticated functions. In particular, cell membranes, which are 2D structures in biological systems, have various characteristics such as a large surface, flexibility, and molecule-recognition ability. Supramolecular 2D materials based on biological systems provide a novel perspective for the deve...

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“…These materials can further be utilized for diverse applications including gene and drug delivery, selfhealing, adsorbents, adhesives, sensing and soft materials. [23][24][25][26][27][28][29] Highly complicated supramolecular structures, such as supramolecular amphiphiles, supramolecular polymers, and molecular machines, have been successfully developed [30][31][32][33] based on hostguest complexation using the aforementioned macrocycles. Macrocycles can be broadly classified into two categories based on their solubility.…”

Section: Bin LImentioning

confidence: 99%