Self-assembly of biological structures

Kushner, D. J.

doi:10.1128/br.33.2.302-345.1969

Cited by 135 publications

(70 citation statements)

References 222 publications

(10 reference statements)

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“…The role of temperature decrease in the complex phenomena under study finds support from many examples of alterations in protein tertiary or quaternary structure or biological activity and in self-assembly of biological structures (Kushner, 1969). These changes are in general reversible when the temperatures include: (1) dissociation of the spindle protein of mammalian cells (Inou6 & Sato, 1967); (2) disaggregation of the glycogen phosphorylase of rabbit skeletal muscle (Kastenschmidt, Kastenschmidt & Helmreich, 1968); (3) increased sensitivity of a histidine biosynthetic enzyme to feedback inhibition by histidine (O'Donovan & Ingraham, 1965); (4) changes in lipoprotein structure (Scanu, Pollard, Hirz & Kothary, 1969); in other cases a decrease in temperature represses a gene (Hartman-Goldstein, 1967), or interferes with the maturation of a virus (Rott & Scholtissek, 1968).…”

Section: Discussionmentioning

confidence: 95%

Ribonucleic acid synthesis and transport in animal cells at 27°C

Horisberger

Amos

1970

Biochemical Journal

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The failure to induce glutamine synthetase in retinal cells with hydrocortisone at 27 degrees C (37 degrees C is the normal temperature for induction) led to a study of some aspects of RNA synthesis at 27 degrees C by using the method of selective labelling with radioactive precursors, sucrose-density-gradient centrifugation and radioautography. The low-temperature treatment not only decreases the rate of RNA synthesis but also interferes with the general pattern of RNA maturation and distribution. It has been found that nuclear-cytoplasmic exchange is severely altered at low temperature and may be an explanation of the failure to induce the enzyme. When the temperature is raised from 27 degrees C to 37 degrees C, the incorporation of exogenous radioactive uridine into the RNA is distorted by a pool-dilution effect that results in an ;over-shoot' phenomenon. The kinetics of labelled uridine equilibration into the UMP pool accounts for the difficulty encountered by many investigators in ;chase' efforts with unlabelled nucleosides.

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Section: Discussionmentioning

confidence: 95%

Ribonucleic acid synthesis and transport in animal cells at 27°C

Horisberger

Amos

1970

Biochemical Journal

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“…[32][33][34] Self-assembly itself has been known for many decades to be key in creating natural and biological 3D architectures. [35] Various self-assembly principles on the atomic and molecular scale have already been applied to form crystals, [36,37] membranes, polymeric organized structures, and molecular monolayers. [38][39][40][41] Similarly, metal-organic and macromolecular assemblies, [42][43][44][45] graphene assemblies [46] and carbon foams, [40] nanotubes, [47,48] nanomachines, [49] and nanocolloids [50] were explored in catalysis, [51,52] drug delivery, [48] and plasmonics [53][54][55] applications.…”

Section: D Microelectronicsmentioning

confidence: 99%

“…Self‐assembly has become a popular strategy in basic research around the world to construct nontrivial 3D structures such as optical Fresnel elements (Figure f), micro vehicles (Figure g) and electronic devices (e.g., antennas (Figure h), actuators, (Figure i) and sensors (Figure j)) on the mesoscopic scale . Self‐assembly itself has been known for many decades to be key in creating natural and biological 3D architectures . Various self‐assembly principles on the atomic and molecular scale have already been applied to form crystals, membranes, polymeric organized structures, and molecular monolayers .…”

Section: Introductionmentioning

confidence: 99%

3D Self‐Assembled Microelectronic Devices: Concepts, Materials, Applications

et al. 2019

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www.advmat.de www.advancedsciencenews.com photolithography techniques. New amorphous semiconducting materials are involved in the development of flexible electronics based on high-performance compounds that include organic [82] and inorganic (e.g., copper oxide [83] or indium-gallium-zinc oxide (IGZO) [84] ) semiconductor possessing, for instance, the transparency [85] required in optoelectronic applications. Once fabricated on polymeric ultrathin substrates, these devices offer the flexibility, stretchability, and imperceptibility [85][86][87] for onskin (Figure 3 a,b,d) biomedical applications, such as biosensors capable of conformally wrapping a soft or irregularly shaped 3D biological sample such as a cancer cell or a pollen grain. [88] Demonstrating outstanding mechanical stability, thin-film materials, in particular semiconductors, are superior candidates for 3D applications compared to monocrystalline semiconductors. [87,89,90] Good examples are amorphous oxides and some organic molecular semiconductors [82] (Figure 3b-d) which are particularly attractive for 3D self-assembled microelectronics. By employing substrates with a thickness in the micro-and submicrometer range (Figure 3) many issues associated with mechanical stress on the surface could be mitigated, demonstrating the increased robustness and reliability of thinfilm electronics. [87,89] Electronic skin (e-skin) (Figure 3a,b,d), for Adv. Mater. 2020, 32, 1902994 Adv. Mater. 2020, 32, 1902994 Figure 3. Thin-film flexible electronic devices and applications. a) Mechanical prosthesis with stretchable electronic skin. Adapted with permission. [97] Copyright 2014, Springer Nature. b) Schematics and photograph of imperceptible organic electronics equipped with tactile active sensor matrix. Adapted with permission. [87] Copyright 2013, Springer Nature. c) Complex circuits with 8-bit microprocessors made of 3381 organic thin-film transistors. Adapted with permission. [98] Copyright 2012, IEEE. d) Ultrathin substrate combined with high-performance indium-gallium-zinc oxide (IGZO) circuitry paving the way for active medical devices on contact lenses. [85] Adapted with permission. [85] Copyright 2014, Springer Nature.

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“…Molecular self-assemblyisconsidered asvery fast-growing field of research considering its crucial significance in the field of material science, 1-4 chemistry 3,5,6 and biological science 3,7,8 for diverse applications. The study of molecular assembly of any compound is important since their organization at supramolecular level plays a decisiverole for ascertaining their potential applications as in drug delivery and sensing .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of the Fluorescent Self-Assembled Structures Formed by Benzothiazolone Conjugates and Applications in Cellular Imaging

Gour

Kshtriya²,

Koshti³

et al. 2021

Preprint

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We report <a>the synthesis and characterization of self-assembled</a> structures formed by4-Choro-2(3H)-benzothiazolone (VK) to panchromatic fibers and its application as cell imaging tool. The aggregation properties ofthe synthesized compounds have been studied extensively under different solvent and concentrationand theirmorphologies examined at supramolecular level was observed by microscopic techniques like optical microscopy, fluorescence microscopy, and atomic force microscopy(AFM). Interestingly, the self-assembled structures formed by VKreveal panchromatic emission properties andshow blue, green and red fluorescence under different excitation filters. The intensity of the fluorescence observed was blue>green>red and the dye interestingly do not show any fluorescence quenching, on the other hand reveal photoactive properties under green channel. The mechanisms of formation of the self-assemblies were studied through different techniques like concentration dependent NMR and,UV visible spectroscopy and fluorescencemicroscopic studies.Finally, the utility of VK for cell imaging applications is demonstrated and it can be noted that VK can be efficientlyup taken by mammalian cells and the stained cells reveal panchromatic emission under blue, green and red channel.

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Self-assembly of biological structures

Cited by 135 publications

References 222 publications

Ribonucleic acid synthesis and transport in animal cells at 27°C

Ribonucleic acid synthesis and transport in animal cells at 27°C

3D Self‐Assembled Microelectronic Devices: Concepts, Materials, Applications

Synthesis and Characterization of the Fluorescent Self-Assembled Structures Formed by Benzothiazolone Conjugates and Applications in Cellular Imaging

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