Self‐Assembly of Amphiphilic Janus Dendrimers into Mechanically Robust Supramolecular Hydrogels for Sustained Drug Release

Nummelin, Sami; Liljeström, Ville; Saarikoski, Eve; Ropponen, Jarmo; Nykänen, Antti; Linko, Veikko; Seppälä, Jukka; Hirvonen, Jouni; Ikkala, Olli; Bimbo, Luís M.; Kostiainen, Mauri A.

doi:10.1002/chem.201501812

Cited by 45 publications

(34 citation statements)

References 55 publications

(61 reference statements)

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“…In a separate attempt, Nummelin et al. reported Janus dendrimer based gel via coupling of isomeric O‐alkylated benzyl groups and hydroxyl terminated 2,2‐bis(methyol)propionic acid based polyester dendrons . They found hydrogel behaviour with extremely low critical gelation concentration (CGC) up to 0.2 wt%.…”

Section: Resultsmentioning

confidence: 91%

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Janus Dendrimer from Poly(Aryl Ether) Linked PAMAM for Supergelation and Guest Release

Prabakaran

Prasad

2016

ChemistrySelect

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The present work reports an easy-to-make procedure of Janus dendrimers containing two most widely used dendrons [poly (aryl ether) and poly(amido amine) {PAMAM}], and utilize them, for the first time, to form a hydrogel with supergelation ability. The first generation (G 1 G 1 ) Janus dendrimer forms hydrogel with a critical gelation concentration (CGC) of 6.5 mg/mL, whereas the CGC for G 1 G 1.5 dendrimer went as low as 0.90 mg/ mL in DMSO-H 2 O mixture. Judicious choice of solvent medium (ethanol-water) led to the formation of flexible morphology (long fibres to vesicles) by the Janus dendrimers, suggesting the possibility of tuning the mechanism of self-assembly in the system. The dye (rhodamine B) loading efficiency in the gel was successfully carried out using different generations {G 1 G 1 and G 1 G 1.5 } of the Janus dendrimer. Generation G 1 G 1 hydrogel (1 wt%) showed maximum dye loading efficiency of 4 mg/mL. Rhodamine B release profiles from the Janus dendrimers were determined and the results indicate that slow release kinetics was observed in the case of G 1 G 1 , where the self-assembly is robust.

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Section: Resultsmentioning

confidence: 91%

“…For example, studies from Nummelin et al. indicate that Janus dendritic hydrogels can be effectively utilized for enzymes and drug delivery . Recently, Yang et al.…”

Section: Introductionmentioning

confidence: 99%

Janus Dendrimer from Poly(Aryl Ether) Linked PAMAM for Supergelation and Guest Release

Prabakaran

Prasad

2016

ChemistrySelect

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“…The amount of Dox released was measured at 37 °C. Buffer solution (4 mL) was taken out from the buffer solution outside the dialysis bag for UV-visible spectrophotometer detection (detection wavelength is 485 nm) at different times (1,2,4,8,12,24,36,48,72,84,96,108, and 120 h), whereas 4 mL fresh buffer solution was added into the buffer solution outside the dialysis bag.…”

Section: The Release Behavior Of Dox From the La-peg-g-dox Nanomedicinementioning

confidence: 99%

“…Therefore, new green therapies need to be discovered to reduce the side effects of traditional cancer treatment is an urgent problem to be solved [2] . Various drug carriers provide a solution to the above problems [3][4][5][6] . Drug carriers can change the pharmacokinetic properties of the chemotherapy drug.…”

Section: Introductionmentioning

confidence: 99%

Delay Tumor Growth Properties of LA-PEG-G Molecule and Its' Application as Drug Carrier

Wei¹,

Xin²,

Wang³

et al. 2020

Preprint

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LA–PEG–G molecule was prepared through the covalent conjugation of linoleic acid, polyethylene glycol and guanosine. LA–PEG–G molecule can self-assemble into spherical aggregate in aqueous solution. The size of the LA–PEG–G aggregate was approximately 132.1 ± 13.718 nm, and the Zeta potential was −36.3 ± 0.9644 mv. The loading rate of LA–PEG–G aggregates to Dox was 84.62 ± 1.810%. In vitro release experiments showed that Dox release from the LA–PEG–G–Dox nanomedicine was slow-release. Cell experiments showed that LA–PEG–G aggregates have low cytotoxicity, and the relative cancer cells survival rate decreased with the increasing of time and LA–PEG–G–Dox nanomedicine concentration. In vivo experiments showed that LA–PEG–G–Dox nanomedicine can inhibit tumor growth, and the LA–PEG–G aggregate could also delay the tumor growth which is very important to play the synergistic antitumor effect with the anticancer drug. Serum biochemistry showed that LA–PEG–G–Dox nanomedicine which reduced the Dox toxicity had very good antitumor effect. The tumor tissue sections indicated that LA–PEG–G–Dox nanomedicine can effectively induce tumor cell apoptosis, and finally cause tissue necrosis to achieve tumor treatment.

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“…[5] In this regard, amphiphilic block copolymers, [6] Janus dendrimers, [5b, 7] giant surfactants, [8] proteins, [9] colloidal particles, [10] and others [11] have revolutionized fundamental understanding of the scope and limitations of molecular architecture while self-assembling. [12] These advances further fuel countless innovations in smart nano-carriers, [13] in vivo imaging vehicles, [14] or artificial organelles. [15] Though chosen by nature,lipid-type geometry itself,with one head and two extended tails,h as rarely been studied in am agnified size,w hich necessitates the design and investigation of aprototype system.…”

Section: Introductionmentioning

confidence: 99%

Magnifying the Structural Components of Biomembranes: A Prototype for the Study of the Self‐Assembly of Giant Lipids

et al. 2020

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How biomembranes are self‐organized to perform their functions remains a pivotal issue in biological and chemical science. Understanding the self‐assembly principles of lipid‐like molecules hence becomes crucial. Herein, we report the mesostructural evolution of amphiphilic sphere‐rod conjugates (giant lipids), and study the roles of geometric parameters (head–tail ratio and cross‐sectional area) during this course. As a prototype system, giant lipids resemble natural lipidic molecules by capturing their essential features. The self‐assembly behavior of two categories of giant lipids (I‐shape and T‐shape, a total of 8 molecules) is demonstrated. A rich variety of mesostructures is constructed in solution state and their molecular packing models are rationally understood. Giant lipids recast the phase behavior of natural lipids to a certain degree and the abundant self‐assembled morphologies reveal distinct physiochemical behaviors when geometric parameters deviate from natural analogues.

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Self‐Assembly of Amphiphilic Janus Dendrimers into Mechanically Robust Supramolecular Hydrogels for Sustained Drug Release

Cited by 45 publications

References 55 publications

Janus Dendrimer from Poly(Aryl Ether) Linked PAMAM for Supergelation and Guest Release

Janus Dendrimer from Poly(Aryl Ether) Linked PAMAM for Supergelation and Guest Release

Delay Tumor Growth Properties of LA-PEG-G Molecule and Its' Application as Drug Carrier

Magnifying the Structural Components of Biomembranes: A Prototype for the Study of the Self‐Assembly of Giant Lipids

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