Self-assembly and sedimentation of 5 nm SPIONs using horizontal, high magnetic fields and gradients

Gómez-Pastora, Jenifer; Wu, Xian; Sundar, N.S.; Alawi, Jamal; Nabar, G. M.; Winter, Jessica O.; Zborowski, Maciej; Chalmers, Jeffrey J.

doi:10.1016/j.seppur.2020.117012

Cited by 12 publications

(10 citation statements)

References 37 publications

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“…Thus, the micro-QMS exhibits an outstandingly improved efficiency, which substantiates its potential for being used for the recovery of magnetic beads when relatively high flow rates are required. These flow rates can be further increased by using higher magnetic field gradients, such as the ones considered in several QMSs published in the literature, namely, 300 T·m –1 or 1750 T·m –1 . , Assuming that these magnetic gradients can be ensured in the micro-QMS presented here (or one with a similar cross sectional area) by employing permanent magnets with a higher maximum magnetic field at their pole tips, and keeping the magnetic field value high enough to saturate the particles, complete bead capture can be fulfilled at flow rates of 18 mL·min –1 and 104 mL·min –1 ; these values correspond to flow rates of approximately 1.6 (∇ B = 300 T·m –1 ) and 9.5 (∇ B = 1750 T·m –1 ) times higher than the ones than can be processed when using the 186 T·m –1 gradient employed in this study. However, increasing the magnetic field gradient by reducing the QMS radius (instead of increasing the maximum magnetic field) could entail an undesirable decrease of the flow rate that can be processed for providing entire bead capture.…”

Section: Resultsmentioning

confidence: 99%

“…Generating regions with high magnetic field gradients has become a potential strategy for enhancing the efficiency of these systems. To this end, the use of several permanent magnets arranged in a quadrupolar orientation, which gives rise to a quadrupole magnetic sorter (QMS), represents an outstanding alternative since field gradients higher than those typically reached by a single permanent magnet could be obtained with QMSs. ,− Thereby, several QMSs have been designed and tested over the years for carrying out the magnetic isolation of both not labeled and labeled cells with magnetic beads. − …”

Section: Introductionmentioning

confidence: 99%

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Recovery of Magnetic Catalysts: Advanced Design for Process Intensification

González-Fernández

Gómez-Pastora

Bringas

et al. 2021

Ind. Eng. Chem. Res.

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The design of microdevices in which components with magnetic character must be separated and recovered from reactive media benefits from the advantages of microfluidics and meets the criteria for process intensification; however, there are open questions, such as the design of the most appropriate magnet arrangement, that need further research in order to increase the magnetic gradient exerted on the particles. Herein, we focus on the continuous recovery of magnetic microparticles, that can be used as support to facilitate the recovery of biocatalysts (magnetic microcatalysts, MMCs) from biological fluids. We analyze and compare the performance of two typical magnetophoretic microdevices for addressing bead recovery: (i) annular channels with a quadrupole orientation of the permanent magnets (quadrupole magnetic sorter, QMS) and (ii) the standard design, which consists of rectangular channels with a single permanent magnet to generate the magnetic field. To this end, an experimentally validated computational fluid dynamics (CFD) numerical model has been employed. Our results reveal that for devices with the same width and length, the micro-QMS, in comparison to a rectangular channel, could accomplish the complete particle retrieval while (i) processing more than 4 times higher fluid velocities, treating more than 360 times higher flow rates or (ii) working with smaller particles, thus reducing by 55% the particle mass. Additionally, the parallel performance of ≈300 micro-QMSs fulfills the processing of flow rates as high as 200 L·h –1 while entirely capturing the magnetic beads. Thereby, this work shows the potential of the QMS advanced design in the intensification of the recovery of catalysts supports of magnetic character.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recovery of Magnetic Catalysts: Advanced Design for Process Intensification

González-Fernández

Gómez-Pastora

Bringas

et al. 2021

Ind. Eng. Chem. Res.

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“…The magnetization of the bead is a function of the applied magnetic field. It is a linear function of the field (χH) up to a magnetic flux of approximately 0.1-0.5 T [31,82], after which it remains nearly constant, with a saturation magnetization of M sat that is independent of the applied magnetic field [31]. In the saturation region, Equation (6) needs to be replaced by the following equation [82]:…”

Section: Magnetic Forcesmentioning

confidence: 99%

“…It should be noted that a precise calculation of the interparticle effects as well as the effects that the particles have on the fluid field might be required for some applications. For example, magnetic dipole-dipole interactions or electrostatic interactions between particulate material could be beneficial for the separation process as they may speed up the aggregation of the material and/or magnify the force acting on it [82]. On the other hand, modifying the flow patterns as the material is separated might have detrimental consequences for the process if mixing is undesired and could underestimate the value of the force required for separation [33].…”

Section: Conclusion and Further Directionsmentioning

confidence: 99%

Novel Approaches Concerning the Numerical Modeling of Particle and Cell Separation in Microchannels: A Review

Karampelas¹,

Gómez-Pastora

2022

Processes

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The demand for precise separation of particles, cells, and other biological matter has significantly increased in recent years, leading to heightened scientific interest in this topic. More recently, due to advances in computational techniques and hardware, numerical simulations have been used to guide the design of separation devices. In this article, we establish the theoretical basis governing fluid flow and particle separation and then summarize the computational work performed in the field of particle and cell separation in the last five years with an emphasis on magnetic, dielectric, and acoustic methods. Nearly 70 articles are being reviewed and categorized depending on the type of material separated, fluid medium, software used, and experimental validation, with a brief description of some of the most notable results. Finally, further conclusions, future guidelines, and suggestions for potential improvement are highlighted.

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“…The foremost advantages of IONPs are (1) their superparamagnetic behavior that enables easy handling and manipulation using an external magnetic field [ 33 ], (2) their low-cost synthesis (mainly iron salts in an alkaline environment and the chemicals for surface modification) [ 34 ] and (3) a high surface-to-volume ratio [ 35 ]. To adjust the surface properties, IONPs are coated or functionalized to avoid aggregation or biodegradation, and to enhance their selectivity for adsorption of target molecules [ 36 – 38 ].…”

Section: Introductionmentioning

confidence: 99%

Bio-nano interactions: binding proteins, polysaccharides, lipids and nucleic acids onto magnetic nanoparticles

2021

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The major interest in nanoparticles as an application platform for biotechnology arises from their high surface-to-volume ratio. Iron oxide nanoparticles (IONPs) are particularly appealing due to their superparamagnetic behavior, which enables bioseparation using external magnetic fields. In order to design advanced biomaterials, improve binding capacities and develop innovative processing solutions, a thorough understanding of the factors governing organic-inorganic binding in solution is critical but has not yet been achieved, given the wide variety of chemical and physical influences. This paper offers a critical review of experimental studies of the interactions between low cost IONPs (bare iron oxides, silica-coated or easily-functionalized surfaces) and the main groups of biomolecules: proteins, lipids, nucleic acids and carbohydrates. Special attention is devoted to the driving forces and interdependencies responsible of interactions at the solid-liquid interface, to the unique structural characteristics of each biomolecular class, and to environmental conditions influencing adsorption. Furthermore, studies focusing on mixtures, which are still rare, but absolutely necessary to understand the biocorona, are also included. This review concludes with a discussion of future work needed to fill the gaps in knowledge of bio-nano interactions, seeking to improve nanoparticles’ targeting capabilities in complex systems, and to open the door for multipurpose recognition and bioseparation processes.

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Self-assembly and sedimentation of 5 nm SPIONs using horizontal, high magnetic fields and gradients

Cited by 12 publications

References 37 publications

Recovery of Magnetic Catalysts: Advanced Design for Process Intensification

Recovery of Magnetic Catalysts: Advanced Design for Process Intensification

Novel Approaches Concerning the Numerical Modeling of Particle and Cell Separation in Microchannels: A Review

Bio-nano interactions: binding proteins, polysaccharides, lipids and nucleic acids onto magnetic nanoparticles

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