Novel Approaches Concerning the Numerical Modeling of Particle and Cell Separation in Microchannels: A Review

Karampelas, Ioannis; Gómez-Pastora, Jenifer

doi:10.3390/pr10061226

Cited by 13 publications

(6 citation statements)

References 79 publications

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“…JMP was used to determine the model effects of (𝑥, 𝑦) position on the experimentally measure force field proportional constants, 𝐒 𝑚 . Equation (7) shows the initial model parameters used to describe the shape of the 𝐒 𝑚 field. An iterative procedure was performed to remove model parameters from the model until only the remaining parameters had a p-value less than 0.05 in the model.…”

Section: Resultsmentioning

confidence: 99%

“…The resulting data is then analyzed using JMP statistical analysis software to quantify the force field distribution by fitting the measured quantities to spatial distribution functions described by Equation (7). Equation ( 7) represents the local magnetic field driving force, 𝐒 𝑚 , which is a vector function of position (𝑥, 𝑦) and is composed of two components: 𝑆 𝑚,𝑥 and 𝑆 𝑚,𝑦 .…”

Section: Experimental Measurementmentioning

confidence: 99%

“…Applications of particle‐pheresis include studies on bioremediation using nanoparticles [1], acoustic separators for particulate and cell separators [2], and enhanced magnetic resonance imaging (MRI) through the use of magnetic nanoparticles [3], among others. Indeed, electrophoresis, dielectrophoresis, magnetophoresis, acoustophoresis, and so forth have been the focus of intense research in the last few decades for their ability to precisely manipulate and separate particles and cells [4–8]. In this work we focus on magnetophoresis of micron‐sized particles with the goal of quantifying spatial distribution of magnetic forces inside microfluidic magnetic devices.…”

Section: Introductionmentioning

confidence: 99%

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Measuring magnetic force field distributions in microfluidic devices: Experimental and numerical approaches

Strayer,

Choe,

et al. 2023

Electrophoresis

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Precisely and accurately determining the magnetic force and its spatial distribution in microfluidic devices is challenging. Typically, magnetic microfluidic devices are designed in a way to both maximize the force within the separation region and to minimize the necessity for knowing such details—such as designing magnetic geometries that create regions of nearly constant magnetic force or that dictate the behavior of the magnetic force to be highly predictable in a specified region. In this work, we present a method to determine the spatial distribution of the magnetic force field in a magnetic microfluidic device by particle tracking magnetophoresis. Polystyrene microparticles were suspended in a paramagnetic fluid, gadolinium, and this suspension was exposed to various magnetic field geometries. Polystyrene particle motion was tracked using a microscope and images processed using Fiji (ImageJ). From a sample with a large spatial distribution of particle tracks, the magnetic force field distribution was calculated. The force field distribution was fitted to nonlinear spatial distribution models. These experimental models are compared to and supported by 3D simulations of the magnetic force field in COMSOL.

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Section: Resultsmentioning

confidence: 99%

Section: Experimental Measurementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Measuring magnetic force field distributions in microfluidic devices: Experimental and numerical approaches

Strayer,

Choe,

et al. 2023

Electrophoresis

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“…It is important to note that, with the exception of micromilling, unconventional procedures are frequently used in the production of microchannels. With the exception of circular channels, which are essentially manufactured on the interior of the base material, the channels are produced on the exterior of the base material 285,[290][291][292][293][294][295][296][297] . Other fabrication methods have been utilised in several research, however much of this literature is unavailable.…”

Section: Fabrication Of Microchannelsmentioning

confidence: 99%

A Review on Microchannel Fabrication Methods and Applications in Large-Scale and Prospective Industries

Afzal¹,

Tayyaba²,

Ashraf³

et al. 2022

Evergreen

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Microchannels based on microelectromechanical systems (MEMS) have received a lot of interest in the microfluidics and biomedical fields over the past forty years. While their applications have been multifarious, a comprehensive literature review focusing on their design, type, and applications is not currently present in the literature. Researchers working on these elements of microchannels will gain targeted knowledge from the current review on microchannels. Due to its advanced properties, flexibility of mass, and small size, microdevice demand has been rising quickly, particularly in industrial applications. The classification of microchannels and their uses are the main focus of this work. These include but are not limited to molding, electroplating, lithography, lab-ona-chip, micromolding, micromachining, micromilling, laser ablation, lithography, microcontact printing (µcp), hot embossing, electrochemical micromachining (EMM), and etching. In addition, numerous hybrid techniques for microchannel manufacturing have been reported. So, in essence, this review offers a range of advancements in microchannel manufacturing. The review also attempts to present a qualitative analysis describing the various methodologies associated with microchannels in terms of their design, shape, and flow regimes for applications such as pressure drop and transfer of heat prediction. Additionally, depending on the precise uses needed, a number of materials, including but not limited to ceramics, silicon, metals, and polymers, are utilized in the manufacture of microchannels. On metallic substrates, polymers such as silicon, glass, and polymeric materials are used. The biomedical industry uses polymeric and glass substrates instead of silicon substrates, which are used for mechanical engineering and electronic applications. In addition to outlining methods for choosing the best kind of microchannel, this paper also suggests important directions for the future.

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“…Magnetophoresis, a term used as an analogy to electrophoresis, describes particle and/or cell motion in a viscous medium under the influence of magnetic fields (Gómez‐Pastora, Moore et al, 2022; Zborowski et al, 2002). Magnetophoretic‐based techniques are presented as simple, low‐cost, and portable technologies that can be used to manipulate biological material, in comparison to other methods for blood cell manipulation such as electrophoresis, thermophoresis, dielectrophoresis, optical trapping, and acoustophoresis (Karampelas & Gómez‐Pastora, 2022; Zhu & Trung Nguyen, 2010). Even at a low volume fraction, the paramagnetic constituents of a cell (in this case, iron) control the cell's volume magnetic susceptibility, as they have a high magnetic susceptibility relative to the diamagnetic constituents of the cell (Xue et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Iron in blood cells: Function, relation to disease, and potential for magnetic separation

Barua

Ciannella

Tijani

et al. 2023

Biotech & Bioengineering

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Iron in blood cells has several physiological functions like transporting oxygen to cells and maintaining iron homeostasis. Iron is primarily contained in red blood cells (RBCs), but monocytes also store iron as these cells are responsible for the recycling of senescent RBCs. Iron also serves an important role related to the function of different leukocytes. In inflammation, iron homeostasis is dependent on cytokines derived from T cells and macrophages. Fluctuations of iron content in the body lead to different diseases. Iron deficiency, which is also known as anemia, hampers different physiological processes in the human body. On the other hand, genetic or acquired hemochromatosis ultimately results in iron overload and leads to the failure of different vital organs. Different diagnoses and treatments are developed for these kinds of disorders, but the majority are costly and suffer from side effects. To address this issue, magnetophoresis could be an attractive technology for the diagnosis (and in some cases treatment) of these pathologies due to the paramagnetic character of the cells containing iron. In this review, we discuss the main functions of iron in blood cells and iron‐related diseases in humans and highlight the potential of magnetophoresis for diagnosing and treating some of these disorders.

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Novel Approaches Concerning the Numerical Modeling of Particle and Cell Separation in Microchannels: A Review

Cited by 13 publications

References 79 publications

Measuring magnetic force field distributions in microfluidic devices: Experimental and numerical approaches

Measuring magnetic force field distributions in microfluidic devices: Experimental and numerical approaches

A Review on Microchannel Fabrication Methods and Applications in Large-Scale and Prospective Industries

Iron in blood cells: Function, relation to disease, and potential for magnetic separation

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