Self-assembly and cytotoxicity study of waterwheel-like dinuclear metal complexes: The first metal complexes appended with multiple free hydroxamic acid groups

Wang, Wenhua; Liu, Weisheng; Wang, Yawen; Yang, Li; Zheng, Liqin; Wang, Daqi

doi:10.1016/j.jinorgbio.2006.10.002

Cited by 14 publications

(2 citation statements)

References 47 publications

(40 reference statements)

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“…Wang et al [270] have reported the self-assembly synthesis of the waterwheel-like dimetal HPHA complex (73) appended with four free hydroxamic acid groups. Waterwheel-like dimetal copper and zinc complexes were evaluated for their in vitro cytotoxic activity against SMMC-7721 and HO-8910 cancer cells.…”

Section: Miscellaneous Complexesmentioning

confidence: 99%

Copper Complexes as Anticancer Agents

Marzano

Pellei²,

Tisato³

et al. 2009

ACAMC

715

395

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Metal-based antitumor drugs play a relevant role in antiblastic chemotherapy. Cisplatin is regarded as one of the most effective drugs, even if severe toxicities and drug resistance phenomena limit its clinical use. Therefore, in recent years there has been a rapid expansion in research and development of novel metal-based anticancer drugs to improve clinical effectiveness, to reduce general toxicity and to broaden the spectrum of activity. The variety of metal ion functions in biology has stimulated the development of new metallodrugs other than Pt drugs with the aim to obtain compounds acting via alternative mechanisms of action. Among non-Pt compounds, copper complexes are potentially attractive as anticancer agents. Actually, since many years a lot of researches have actively investigated copper compounds based on the assumption proposal that endogenous metals may be less toxic. It has been established that the properties of copper-coordinated compounds are largely determined by the nature of ligands and donor atoms bound to the metal ion. In this review, the most remarkable achievements in the design and development of copper(I, II) complexes as antitumor agents are discussed. Special emphasis has been focused on the identification of structure-activity relationships for the different classes of copper(I,II) complexes. This work was motivated by the observation that no comprehensive surveys of copper complexes as anticancer agents were available in the literature. Moreover, up to now, despite the enormous efforts in synthesizing different classes of copper complexes, very few data concerning the molecular basis of the mechanisms underlying their antitumor activity are available. This overview, collecting the most significant strategies adopted in the last ten years to design promising anticancer copper(I,II) compounds, would be a help to the researchers working in this field.

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Section: Miscellaneous Complexesmentioning

confidence: 99%

Copper Complexes as Anticancer Agents

Marzano

Pellei²,

Tisato³

et al. 2009

ACAMC

715

395

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“…Hydroxamic acids play a vital role in development of organic and inorganic molecules [1] and they have also being valuable intermediates in the pharmaceutical applications [2,3,4,5]. The exploration of their biological activity features with different metal ions assigning to their inhibitory action against enzymes having metallo-protein as their functional group [6,7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral analysis, molecular docking and DFT studies of 3-(2, 6-dichlorophenyl)-acrylamide and its dimer through QTAIM approach

Shukla

Chaudhary²,

Pandey

2020

Heliyon

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In this paper, an experimental study of ( E )-3-(2,6-dichlorophenyl)-acrylamide and its associated dimer were analysed with molecular docking, DFT and QTAIM approach. To spot, describe, and measure the non-covalent interactions (NCIs) of the atoms in the molecules of the monomer and its dimer, some important topological parameters of the charge densities, ρ(r) acquired from the Bader's QTAIM tool are determined, quantitatively. The bond paths are shown to persist for a range of five types of NCIs such as weak conventional (C-H···Cl) and nonconventional (C-O···C and N-O···Cl), medium (N-H···Cl) and strong O-H···O NCIs revealed by the existence of BCPs (ranging from 1.921 - 3.259 Å). A comprehensive explanation of the spectroscopic data like vibrational, electronic, and NMR spectra is reported along with the NLO, reactivity. Hydroxamic acid exhibited an excellent nonlinear optical activity (β 0 = 14.8098 × 10 −30 ). To predict the various reactive sites in the molecule, molecular electrostatic potential diagrams were displayed.

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