Cytotoxicity, alpha-glucosidase inhibition and molecular docking studies of hydroxamic acid chromium(III) complexes

Design, synthesis, spectroscopic characterization, computational analysis, and in vitro α-amylase and α-glucosidase evaluation of 3-aminopyridin-2(1H)-one based novel monothiooxamides and 1,3,4-thiadiazoles

“…This method has also been successfully used to study the binding mechanisms of many alpha-glucosidase inhibitors. 56–58…”

“…This method has also been successfully used to study the binding mechanisms of many alpha-glucosidase inhibitors. [56][57][58] In the current study, four target receptors (i.e. FFA1, lysosomal alpha-glucosidase, α-glucosidase and α-amylase,) were selected because they play an important and critical role in maintaining glucose levels in the body.…”

A review on α-glucosidase inhibitory activity of first row transition metal complexes: a futuristic strategy for treatment of type 2 diabetes

“…Hassan et al reported a-glucosidase inhibitory activity of Cr(III) complexes 107-110 (Table 5, entry 7) of hydroxamic acid derivatives L29-L32 (Table 5, entry 1) comparing with acarbose as the standard drug (IC 50 ¼ 418 mM). 85 The efficacy of hydroxamic acid derivatives (L29-L32) were found to be more effective than PicAs (L11, L12, and L17), in spite the fact that all ligands were not inhibitor of a-glucosidase. Also, the presence of various substituents on hydroxamic acid moiety played an important role in the inhibitory activity.…”

“…However, their exact mechanism of action toward enzyme is not denitely clear. In this respect, the interaction mode of some potent compounds 5, 13,26,34,42,47,85,115,132,133, and 168 were investigated (Fig. 4).…”

“…(ii) Molecular docking of some complexes (5,13,26,34,42,47,85,115,132, and 133, and 168) were performed to predict binding conformations and interactions between ligands and the binding site of a-glucosidase.…”