Self-assembling peptide semiconductors

Tao, Kai; Makam, Pandeeswar; Aizen, Ruth; Gazit, Ehud

doi:10.1126/science.aam9756

Cited by 372 publications

(329 citation statements)

References 91 publications

(132 reference statements)

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“…With extensive and directional hydrogen bonding and aromatic interactions serving as the driving forces, aromatic short peptides can provide new frontiers of smart materials, allowing a better interface between photoactive constituents and sustainable optoelectronics. Hence, attempts are being made to utilize these properties toward developing bioorganic semiconductors …”

Section: Introductionmentioning

confidence: 99%

Enhanced Fluorescence for Bioassembly by Environment‐Switching Doping of Metal Ions

Tao

Orr

et al. 2020

Adv Funct Materials

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The self‐assembly of cyclodipeptides composed of natural aromatic amino acids into supramolecular structures of diverse morphologies with intrinsic emissions in the visible light region is demonstrated. The assembly process can be halted at the initial oligomerization by coordination with zinc ions, with the most prominent effect observed for cyclo‐dihistidine (cyclo‐HH). This process is mediated by attracting and pulling of the metal ions from the solvent into the peptide environment, rather than by direct interaction in the solvent as commonly accepted, thus forming an “environment‐switching” doping mechanism. The doping induces a change of cyclo‐HH molecular configurations and leads to the formation of pseudo “core/shell” clusters, comprising peptides and zinc ions organized in ordered conformations partially surrounded by relatively amorphous layers, thus significantly enhancing the emissions and allowing the application of the assemblies for ecofriendly color‐converted light emitting diodes. These findings shed light into the very initial coordination procedure and elucidate an alternative mechanism of metal ions doping on biomolecules, thus presenting a promising avenue for integration of the bioorganic world and the optoelectronic field.

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Section: Introductionmentioning

confidence: 99%

Enhanced Fluorescence for Bioassembly by Environment‐Switching Doping of Metal Ions

Tao

Orr

et al. 2020

Adv Funct Materials

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“…Biodegradable natural materials with diverse electrical and mechanical properties can be employed as data‐storage layer in memories to promise an alternative approach to replace conventional inorganic semiconductors. In addition, biomaterials allow a biocompatible interface between electronic devices and biological worlds, thus broadening corresponding biotechnological and medicinal applications, such as implantable chips, artificial neurons, and electronic skin 20, 21, 22, 23, 24. Various types of biomaterials have been used as active units for fabrication of data‐storage devices, such as protein, polysaccharide, nucleic acid, and virus 25, 26, 27, 28, 29, 30.…”

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confidence: 99%

Phototunable Biomemory Based on Light‐Mediated Charge Trap

et al. 2018

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Phototunable biomaterial‐based resistive memory devices and understanding of their underlying switching mechanisms may pave a way toward new paradigm of smart and green electronics. Here, resistive switching behavior of photonic biomemory based on a novel structure of metal anode/carbon dots (CDs)‐silk protein/indium tin oxide is systematically investigated, with Al, Au, and Ag anodes as case studies. The charge trapping/detrapping and metal filaments formation/rupture are observed by in situ Kelvin probe force microscopy investigations and scanning electron microscopy and energy‐dispersive spectroscopy microanalysis, which demonstrates that the resistive switching behavior of Al, Au anode‐based device are related to the space‐charge‐limited‐conduction, while electrochemical metallization is the main mechanism for resistive transitions of Ag anode‐based devices. Incorporation of CDs with light‐adjustable charge trapping capacity is found to be responsible for phototunable resistive switching properties of CDs‐based resistive random access memory by performing the ultraviolet light illumination studies on as‐fabricated devices. The synergistic effect of photovoltaics and photogating can effectively enhance the internal electrical field to reduce the switching voltage. This demonstration provides a practical route for next‐generation biocompatible electronics.

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“…Recombinant peptides could be designed to modulate the morphology of the supramolecular assembly and tune the optical and conductive properties of the material (Tao et al ., 2017). Knowledge about the amino acids that mediate the conductivity is also critical to manipulate the conductive properties of the peptides and assemblies.…”

Section: Discussionmentioning

confidence: 99%

Harnessing the power of microbial nanowires

Reguera

2018

Microbial Biotechnology

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SummaryThe reduction of iron oxide minerals and uranium in model metal reducers in the genus Geobacter is mediated by conductive pili composed primarily of a structurally divergent pilin peptide that is otherwise recognized, processed and assembled in the inner membrane by a conserved Type IVa pilus apparatus. Electronic coupling among the peptides is promoted upon assembly, allowing the discharge of respiratory electrons at rates that greatly exceed the rates of cellular respiration. Harnessing the unique properties of these conductive appendages and their peptide building blocks in metal bioremediation will require understanding of how the pilins assemble to form a protein nanowire with specialized sites for metal immobilization. Also important are insights into how cells assemble the pili to make an electroactive matrix and grow on electrodes as biofilms that harvest electrical currents from the oxidation of waste organic substrates. Genetic engineering shows promise to modulate the properties of the peptide building blocks, protein nanowires and current‐harvesting biofilms for various applications. This minireview discusses what is known about the pilus material properties and reactions they catalyse and how this information can be harnessed in nanotechnology, bioremediation and bioenergy applications.

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Self-assembling peptide semiconductors

Cited by 372 publications

References 91 publications

Enhanced Fluorescence for Bioassembly by Environment‐Switching Doping of Metal Ions

Enhanced Fluorescence for Bioassembly by Environment‐Switching Doping of Metal Ions

Phototunable Biomemory Based on Light‐Mediated Charge Trap

Harnessing the power of microbial nanowires

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