Self-assembling peptide scaffolds in the clinic

Gelain, Fabrizio; Luo, Zhongli; Rioult, Marc G.; Zhang, Shuguang

doi:10.1038/s41536-020-00116-w

Cited by 80 publications

(60 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Self-assembling peptides (SAPs) have gained considerable attentions because of their potential applications in biology, nanotechnology, tissue engineering, and regenerative medicine [1][2][3][4]. Rationally designed SAPs can self-assemble into various nanostructures (i.e.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired photo-crosslinkable self-assembling peptides with pH-switchable “on–off” luminescence

2022

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Bioinspired photo-crosslinkable self-assembling peptides with pH-switchable “on–off” luminescence

2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…The main applications of peptides classified in this category are related to their ability to form hydrogels. Such biomaterials can serve as scaffolds for tissue engineering, bioprinting, cell proliferation, regenerative medicine and drug delivery ( Liu and Zhao, 2011 ; Levin et al, 2020 ; Gelain et al, 2021 ).…”

Section: Morphological Control Through Sequence Designmentioning

confidence: 99%

Exploiting Peptide Self-Assembly for the Development of Minimalistic Viral Mimetics

et al. 2021

View full text Add to dashboard Cite

Viruses are natural supramolecular nanostructures that form spontaneously by molecular self-assembly of complex biomolecules. Peptide self-assembly is a versatile tool that allows mimicking viruses by creating their simplified versions through the design of functional, supramolecular materials with modularity, tunability, and responsiveness to chemical and physical stimuli. The main challenge in the design and fabrication of peptide materials is related to the precise control between the peptide sequence and its resulting supramolecular morphology. We provide an overview of existing sequence patterns employed for the development of spherical and fibrillar peptide assemblies that can act as viral mimetics, offering the opportunity to tackle the challenges of viral infections.

show abstract

“…Furthermore, self-assembling peptide-based injectable hydrogels have demonstrated immense potential for clinical application. Briefly, these self-assembling peptides with repeating units like “AEAEAKAKAEAEAKAK” can be synthesized using a solid-phase peptide synthesis technique on a substrate ( 46 , 47 ).…”

Section: Fabrication Of Hydrogelsmentioning

confidence: 99%

De novo Drug Delivery Modalities for Treating Damaged Hearts: Current Challenges and Emerging Solutions

Alvi

Ahmed

Sridharan

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Cardiovascular disease (CVD) is the leading cause of mortality, resulting in approximately one-third of deaths worldwide. Among CVD, acute myocardial infarctions (MI) is the leading cause of death. Current treatment modalities for treating CVD have improved over the years, but the demand for new and innovative therapies has been on the rise. The field of nanomedicine and nanotechnology has opened a new paradigm for treating damaged hearts by providing improved drug delivery methods, specifically targeting injured areas of the myocardium. With the advent of innovative biomaterials, newer therapeutics such as growth factors, stem cells, and exosomes have been successfully delivered to the injured myocardial tissue, promoting improvement in cardiac function. This review focuses on three major drug delivery modalities: nanoparticles, microspheres, and hydrogels, and their potential for treating damaged hearts following an MI.

show abstract

Self-assembling peptide scaffolds in the clinic

Cited by 80 publications

References 51 publications

Bioinspired photo-crosslinkable self-assembling peptides with pH-switchable “on–off” luminescence

Bioinspired photo-crosslinkable self-assembling peptides with pH-switchable “on–off” luminescence

Exploiting Peptide Self-Assembly for the Development of Minimalistic Viral Mimetics

De novo Drug Delivery Modalities for Treating Damaged Hearts: Current Challenges and Emerging Solutions

Contact Info

Product

Resources

About