Self-assembling Peptide P11-4: A Biomimetic Agent for Enamel Remineralization

Bonchev, Alexander; Vasileva, Radosveta; Dyulgerova, Elena; Yantcheva, Sevda

doi:10.1007/s10989-020-10136-1

Cited by 11 publications

(11 citation statements)

References 59 publications

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“…Causes a noticeable alteration in the damaged enamel surface's optical characteristics. Bonchev et al, (13) in this regard, when SAP is applied to a tooth, the peptide diffuse into the subsurface micropores, forming a three-dimensional scaffold of tiny fibers. These scaffolds resemble teeth development proteins and promote hydroxyl apatite crystallization around them to restore tooth enamel over a three-month period.…”

Section: Discussionmentioning

confidence: 99%

Effect of Two Remineralizing Analogues on Treatment of Post Orthodontic Enamel White Spot Lesions Using spectrophotometer: An in Vivo Study

Ali

Elezz

Nadim

et al. 2022

Dental Science Updates

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Introduction: Patients seeking orthodontic treatment are mainly targeting improving their esthetic, but they are faced with an unfavorable side effect of fixed orthodontic treatment, which is enamel demineralization manifested as white spot lesions (WSLs). As a result, it's critical to alter caries risk factors and focus on therapeutic options that emphasize remineralization of lesions. Aim: The purpose of this study was to assess the clinical effect of self-assembling peptides and amorphous calcium phosphate varnish on the treatment of post orthodontic enamel WSLs. Materials and methods. In this prospective single-blinded randomized clinical investigation, a total of 40 patients' teeth (10 per group) were enrolled in four groups; first the control group, two remineralizing analogue groups; Self-assembling peptide P11-4 group (Curodont ™ Repair /Regenamel®), and Amorphous Calcium Phosphate varnish (Enamel Pro® Varnish 5% Sodium Fluoride Premier Dental). The combination of the two analogues were used to form the fourth group; through combining Selfassembling peptide containing a considerable quantity of calcium phosphate and fluoride ions. WSLs were evaluated using Vita Easy® Shade spectrophotometer (Vita Zahnfabrik, Germany) to calculate (∆E) of shade changes, immediately after de-bonding of the orthodontic brackets. Follow ups were done after one, three, and six months. Results: WSLs recovery was significantly better in the combination group followed by the s combine Self-assembling peptide group, than the control group, which had the lowest remineralization levels. Conclusion: Combining organic and inorganic remineralizing analogues showing the highest remineralizing potential reflected by the increase in Vita Easy ® Shade readings.

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Section: Discussionmentioning

confidence: 99%

Effect of Two Remineralizing Analogues on Treatment of Post Orthodontic Enamel White Spot Lesions Using spectrophotometer: An in Vivo Study

Ali

Elezz

Nadim

et al. 2022

Dental Science Updates

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“…The glutamine (Gln) residues of peptide P11-2 are organised in a specific order. These residues have side chains that interact and cause β-sheet formations to form [71]. By replacing the glutamic acid residues at positions 5 and 7 with glutamine residues, peptide P11-4 was induced to remain monomeric at high pH and transform to a nematic gel at low pH [70].…”

Section: Mode Of Actionmentioning

confidence: 99%

Effectiveness of Self-Assembling Peptide (P11-4) in Dental Hard Tissue Conditions: A Comprehensive Review

et al. 2022

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The limitations on the use of fluoride therapy in dental caries prevention has necessitated the development of newer preventive agents. This review focusses on the recent and significant studies on P11-4 peptide with an emphasis on different applications in dental hard tissue conditions. The self-assembling peptide P11-4 diffuses into the subsurface lesion assembles into aggregates throughout the lesion, supporting the nucleation of de novo hydroxyapatite nanocrystals, resulting in increased mineral density. P11-4 treated teeth shows more remarkable changes in the lesion area between the first and second weeks. The biomimetic remineralisation facilitated in conjunction with fluoride application is an effective and non-invasive treatment for early carious lesions. Despite, some studies have reported that the P11-4 group had the least amount of remineralised enamel microhardness and a significantly lower mean calcium/phosphate weight percentage ratio than the others. In addition, when compared to a low-viscosity resin, self-assembling peptides could neither inhibit nor mask the lesions significantly. Moreover, when it is combined with other agents, better results can be achieved, allowing more effective biomimetic remineralisation. Other applications discussed include treatment of dental erosion, tooth whitening and dentinal caries. However, the evidence on its true clinical potential in varied dental diseases still remains under-explored, which calls for future cohort studies on its in vivo efficacy.

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“…474 SAP P 11 -4 creates a biomimetic scaffold within the initial enamel caries lesion resembling the enamel peptide matrix and represents a most promising clinical product. Two very interesting reviews on SAPs were published by Mohamed et al 474 and Bonchev et al 475 Both concluded that this material is effective in remineralizing enamel caries. Although both these systematic reviews were based primarily on in vitro studies, they provide perfect background reading for 2 additional clinical randomized controlled studies published on this topic in 2020.…”

Section: Remineralizationmentioning

confidence: 99%

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

Cagna

Donovan

McKee³

et al. 2021

The Journal of Prosthetic Dentistry

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Self-assembling Peptide P11-4: A Biomimetic Agent for Enamel Remineralization

Cited by 11 publications

References 59 publications

Effect of Two Remineralizing Analogues on Treatment of Post Orthodontic Enamel White Spot Lesions Using spectrophotometer: An in Vivo Study

Effect of Two Remineralizing Analogues on Treatment of Post Orthodontic Enamel White Spot Lesions Using spectrophotometer: An in Vivo Study

Effectiveness of Self-Assembling Peptide (P11-4) in Dental Hard Tissue Conditions: A Comprehensive Review

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

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