No abstract

No abstract

Type 2 diabetes and Nonalcoholic fatty liver disease are two of the most common metabolic diseases in the world, with an increasing prevalence. Patients with T2DM have a two-fold increased risk of developing NAFLD, The evidence that certain antidiabetic drugs boost NAFLD/NASH in T2DM patients is growing. However, there are no specific pharmacologic treatments available. This review aims to outline the data supporting the effectiveness of anti-diabetic drugs in the treatment of NAFLD, besides providing an overview of novel antidiabetic therapies that have been proposed to achieve this goal. Most of these anti-diabetic agents demonstrate short-term efficacy, but have shown little to no impact on hepatic histology. Only thiazolides and GLP-1 receptor agonists have shown considerable improvement in hepatic histology.

Introduction: Aesthetic dentistry has developed in the recent decades. Orthodontic treatment has become one of the more popular ways for alignment of crowded teeth. However, when braces are removed, white spot lesions (WSLs) may have a detrimental impact on the patient's aesthetics and pleasure. Aim: this research aimed to evaluate the clinical effect of Self assembling peptides and Amorphous calcium phosphate varnish on the treatment of post orthodontic enamel WSLs. Materials and methods: A total of 40 patients teeth were enrolled in this prospective single-blinded randomized clinical study categorized into four groups (10 per group); Control group , Self assembling peptide P11-4 group (Curodont ™ Repair /Regenamel®), Amorphous Calcium Phosphate varnish group (Enamel Pro® Varnish 5% Sodium Fluoride Premier Dental) and combination group in which the two analogues were combined with each other. Enamel white spot lesions were evaluated quantitatively using Diagnodent® (KaVo Dental Corporation, USA). Results: A quantitative increase in remineralization of post orthodontic WSLs in all the groups and over time intervals. However, the WSLs recovery was significantly better in the combination group followed by the self-assembling peptide group, than control group which showed the least values of remineralization. Conclusion: Combining self-assembling peptideP11-4 with other inorganic remineralizing analogues provides additional benefits of accelerating and enhancing the remineralization process, allowing for significantly faster and improved regenerative repair for post orthodontic WSLs.

Aim: Oxidative stress has been implicated in the neurological diseases, one of them is epilepsy. Therefore, this study was conducted to determine the effect of vitamin C as an acute antioxidant protective treatment of epilepsy in mice. Materials and Methods: Seventy-eight male albino mice were divided into six groups. The first group was a normal control group that received NaCl, 0.9% (i.p.). The second group received PTZ (65 mg/kg, i.p.) as a single convulsive dose. The third and fourth groups received vitamin C (500 mg/kg/day, i.p.) and vitamin C (1000mg/kg, i.p.) respectively. The fifth and sixth groups received vitamin C (500 mg/kg/day, i.p.) and vitamin C (1000 mg/kg, i.p.) respectively, then after 30 minutes both received Pentylenetetrazole (PTZ) (65 mg/kg i.p.) as a single convulsive dose. Behavioral assessment was done immediately after injections using Racine scale and rotarod tests then after 24 hours, the animals were killed and brain tissue homogenates were prepared to measure lipid peroxide (Malondialdehyde) and catalase activity. Results: Vitamin C showed decreased percentage of seizures, prolonged latency to 1 st seizure, improved motor coordination, decreased lipid peroxide level and increased catalase activity. No difference in results between groups received vitamin C (500 mg/kg, i.p.) or (1000 mg/kg, i.p.). Conclusion: Vitamin C was proven to be a potential candidate for decreasing risk of epilepsy.