Self-assemblies of the six-armed star triblock ABC copolymer: pH-tunable morphologies and drug release

Designed Monomers and Polymers

et al. 2016

An amphipathic spiropyran-based random copolymer P(SPMA-co-DMAEMA) was synthesized by atom transfer radical polymerization, and the resulting copolymer was characterized by means of 1 H nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, and gel permeation chromatography. The self-assembly behaviors and morphology transition were systematically investigated under single and combined external environmental stimuli by transmission electron microscopy. With coumarin 102 as the model drug molecule, the selfassembly micelles were used to control drug loading, release, and re-encapsulation to some extent. The characterization results indicated the successful preparation of the spiropyran-based random copolymer P(SPMA-co-DMAEMA). The external stimuli had some influences on the morphology of the self-assembly aggregate, and the 'schizophrenic' behavior was interestingly found in this work. The drug release experiments showed the reversible loading and release process up to a point, which might expand the potential application domain of the amphiphilic spiropyran-based random copolymer in drug delivery.

Section: Introductionmentioning

confidence: 99%

Self-assembly and morphology transition of amphipathic spiropyran-based random copolymers to control drug release

Chen

Designed Monomers and Polymers

et al. 2016

“…The low CAC value means that the miktoarm star block copolymer has potential applications in drug delivery. [ 7,8,13 ] The micelles from the self-assembly of MSP1 in water were denoted as M1 . Figure 5 shows DLS measurements and a TEM image of M1 .…”

Section: Self-assembly Of Msp1 and Its Temperature Sensitivitymentioning

confidence: 99%

“…[1][2][3][4][5][6][7] Compared with their linear counterparts, star polymers exhibit unique morphologies, properties, and functions, [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] especially miktoarm star polymers. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] This is because a miktoarm star polymer combines different polymer arms into a molecule through a single core.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, amphiphilic star polymers generally exhibit low critical aggregation concentration (CAC) values in aqueous solution. [7][8][9]13,14,18,19 ] This is very benefi cial for drug delivery. [ 7,8 ] Herein, a (BA)(AC) 2 miktoarm star diblock copolymer is reported.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9]13,14,18,19 ] This is very benefi cial for drug delivery. [ 7,8 ] Herein, a (BA)(AC) 2 miktoarm star diblock copolymer is reported. The two arms consist of PMMA-b -PNIPAm (PMMA, poly(methyl methacrylate)) and the other arm is PMMA-b -PPEGMA (poly(poly(ethylene glycol) methyl ether methacrylate)).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Temperature‐Sensitive (BA)(AC)₂ Miktoarm Star Diblock Copolymer Based on PMMA, PPEGMA, and PNIPAm

Zhu

Macro Chemistry & Physics

Xiao

et al. 2016

Self Cite

A well-defi ned (BA)(AC) 2 miktoarm star diblock copolymer, (PPEGMA 32 -b -PMMA 41 )-b -(PMMA 45 -b -PNIPAm 19 ) 2 , is synthesized by the combination of ATRP and click reaction. The miktoarm star block copolymer and its precursors are characterized by means of NMR and SEC/MALLS measurements. The copolymer exhibits a low critical aggregation concentration in aqueous solution. Micelles that self-assemble from the copolymer are prepared in aqueous solution below 15 °C by a sonication method. The micelles have a PMMA core and a PPEGMA/PNIPAm corona and exhibit temperature sensitivity. Using celecoxib as a guest molecule, it is found that the loading capacity of the star copolymer is 8.8 wt% and the celecoxib release from the loaded self-assembly is temperature tunable.

Dual pH‐Sensitive DOX‐Conjugated Cyclodextrin‐Core Star Nano‐Copolymer Prodrugs

Hou

Macro Chemistry & Physics

Sun

et al. 2017

Herein this study reports dual pH‐sensitive doxorubicin (DOX)‐conjugated β‐cyclodextrin‐core star copolymers with tailoring properties such as direct water‐solubility and stability prior to reaching target sites. For these purposes, three kinds of novel well‐defined β‐cyclodextrin‐core poly(2‐(diethylamino)ethyl methacrylate‐co‐4‐formylphenyl methacrylate)‐b‐poly(poly(ethylene glycol) methyl ether methacrylate) star copolymers (CD‐star‐P(DEA‐co‐FPMA)‐b‐PPEGMA, SPDFP1–3) with different poly(ethylene glycol) methyl ether methacrylate contents are designed and synthesized by atom transfer radical polymerization (ATRP) strategy. 4‐Formylphenyl methacrylate is introduced into the inner arm block of the star copolymers for conjugating DOX by imine bond formation. Interestingly, the DOX‐conjugated β‐cyclodextrin‐core star copolymers not only can directly dissolve in aqueous buffer solution of pH 7.0 to form unimolecular micelles without any aid of organic solvent, but also exhibit strong pH‐dependent DOX release. At normal pH 7.4 the DOX amount released is very small, whereas at pH 5.0 DOX can be released. By selecting SPDFP2–DOX as a representative, it is found that the SPDFP2–DOX micelles show less cytotoxicity compared to carrier‐free DOX and can be internalized by HeLa cells. It is expected that the exploration can provide new strategy for preparing drug delivery system.