Temperature‐Sensitive (BA)(AC)₂ Miktoarm Star Diblock Copolymer Based on PMMA, PPEGMA, and PNIPAm

Abstract

A well-defi ned (BA)(AC) 2 miktoarm star diblock copolymer, (PPEGMA 32 -b -PMMA 41 )-b -(PMMA 45 -b -PNIPAm 19 ) 2 , is synthesized by the combination of ATRP and click reaction. The miktoarm star block copolymer and its precursors are characterized by means of NMR and SEC/MALLS measurements. The copolymer exhibits a low critical aggregation concentration in aqueous solution. Micelles that self-assemble from the copolymer are prepared in aqueous solution below 15 °C by a sonication method. The micelles have a PMMA core and a PPEGMA/PNIPAm corona and exhibit temperature sensitivity. Using celecoxib as a guest molecule, it is found that the loading capacity of the star copolymer is 8.8 wt% and the celecoxib release from the loaded self-assembly is temperature tunable.

Silver Metallic Cyclodextrin‐Core Star mPEG

“…Here mPEG is selected as the arms, because of its good biocompatibility and environmental friendliness. The formation of the star was carried out by the copper‐catalyzed azide–alkyne click reaction . On the one hand, the click reaction is highly efficient; on the other hand, it can incorporate the 1,2,3‐triazole moieties into the star architecture.…”

“…III was synthesized by the copper‐catalyzed azide−alkyne click reaction of I and II (Scheme f) . The experiment was carried out in excess of II , and the unreacted II was removed by the dialysis method.…”

“…The formation of the star was carried out by the coppercatalyzed azide-alkyne click reaction. [6,[28][29][30] On the one hand, the click reaction is highly efficient; on the other hand, it can incorporate the 1,2,3-triazole moieties into the star architecture. In this study, the involved synthesis conditions were optimized.…”

“…III was synthesized by the copper-catalyzed azide−alkyne click reaction of I and II (Scheme 1f). [6,[28][29][30] The experiment was carried out in excess of II, and the unreacted II was removed by the dialysis method. As seen from Figure S3, Supporting Information, the presence of the resonance at δ = 7.51 assigned to 1,4-disubstituted-1,2,3-triazole group indicates that the click reaction was carried out.…”

Dual pH‐Sensitive DOX‐Conjugated Cyclodextrin‐Core Star Nano‐Copolymer Prodrugs

“…However, drug nanocarriers self‐assembled from amphiphilic linear copolymers show several drawbacks. First, the formation of micelles depends on the critical aggregation concentration of the amphiphilic linear copolymers, resulting in the fact that the self‐assembled polymeric nanoparticles become significantly unstable under extremely diluted condition and dissociate into free chains . This brings about premature release of the payload.…”