Self-assembled small messenger RNA nanospheres for efficient therapeutic apoptin expression and synergistic Gene-Chemotherapy of breast cancer

Tang, Yuxia; Liao, Xiang; Wang, Chunyan; Liu, Ying; Pan, Jing; Tian, Ying; Teng, Zhaogang; Lu, Guangming

doi:10.1016/j.jcis.2021.06.061

Cited by 7 publications

(2 citation statements)

References 24 publications

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“…An encapsulation FND Dox rate of 18.67% was determined by measuring and calculating the Dox concentration of this fraction. This was higher than the 8.2% observed in earlier studies [ 30 ], indicating that FND has a high Dox encapsulation rate. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) were used to assess the FND when the circumstances were improved (Fig.…”

Section: Resultscontrasting

confidence: 74%

Aptamer functionalized nucleic acid nano drug for targeted synergistic therapy for colon cancer

Zhu

Yuhan

et al. 2023

J Nanobiotechnol

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Due to its complicated pathophysiology, propensity for metastasis, and poor prognosis, colon cancer is challenging to treat and must be managed with a combination of therapy. Using rolling circle transcription (RCT), this work created a nanosponge therapeutic medication system (AS1411@antimiR-21@Dox). Using the AS1411 aptamer, this approach accomplished targeted delivery to cancer cells. Furthermore, analysis of cell viability, cell apoptosis, cell cycle arrest, reactive oxygen species (ROS) content, and mitochondrial membrane potential (MMP) levels revealed that functional nucleic acid nanosponge drug (FND) can kill cancer cells. Moreover, transcriptomics uncovered a putative mechanism for the FND anti-tumor effect. These pathways, which included mitotic metaphase and anaphase as well as the SMAC-mediated dissociation of the IAP: caspase complexes, were principally linked to the cell cycle and cell death. In conclusion, by triggering cell cycle arrest and apoptosis, the nano-synergistic therapeutic system allowed for the intelligent and effective targeted administration of RNA and chemotherapeutic medicines for colon cancer treatment. The system allowed for payload efficiency while being customizable, targeted, reliable, stable, and affordable.

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Section: Resultscontrasting

confidence: 74%

Aptamer functionalized nucleic acid nano drug for targeted synergistic therapy for colon cancer

Zhu

Yuhan

et al. 2023

J Nanobiotechnol

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“…In a targeted drug delivery system, drug molecules are trapped in the nanospheres to avoid drug degradation by enzymes or other substances in circulation and improve the efficacy of drugs [ 98 ]. Tang et al [ 99 ] fabricated self-assembled mRNA nanospheres loaded with DOX, and the experiments showed that the nanospheres efficiently expressed apoptogens and increased the necrosis of tumor tissues, exhibiting the synergistic effects of gene chemotherapy. Moreover, Vahab and Alireza developed nanospheres that were composed of folic acid and poly(methacrylic acid) with pH responsiveness [ 100 ].…”

Section: Targeting Drug Delivery Systemsmentioning

confidence: 99%

Targeted Therapy and Immunotherapy for Heterogeneous Breast Cancer

Sun

Liu

et al. 2022

Cancers

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Breast cancer (BC) is the most common malignancy in women worldwide, and it is a molecularly diverse disease. Heterogeneity can be observed in a wide range of cell types with varying morphologies and behaviors. Molecular classifications are broadly used in clinical diagnosis, including estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), and breast cancer gene (BRCA) mutations, as indicators of tumor heterogeneity. Treatment strategies differ according to the molecular subtype. Besides the traditional treatments, such as hormone (endocrine) therapy, radiotherapy, and chemotherapy, innovative approaches have accelerated BC treatments, which contain targeted therapies and immunotherapy. Among them, monoclonal antibodies, small-molecule inhibitors and antibody–drug conjugates, and targeted delivery systems are promising armamentarium for breast cancer, while checkpoint inhibitors, CAR T cell therapy, cancer vaccines, and tumor-microenvironment-targeted therapy provide a more comprehensive understanding of breast cancer and could assist in developing new therapeutic strategies.

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Self-assembly of DNA-gold nanoaggregate for visual detection of thymidine kinase 1 (TK1) mRNA via lateral flow assay

Wang,

Shi,

Tang

et al. 2023

Microchim Acta

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Self-assembled small messenger RNA nanospheres for efficient therapeutic apoptin expression and synergistic Gene-Chemotherapy of breast cancer

Cited by 7 publications

References 24 publications

Aptamer functionalized nucleic acid nano drug for targeted synergistic therapy for colon cancer

Aptamer functionalized nucleic acid nano drug for targeted synergistic therapy for colon cancer

Targeted Therapy and Immunotherapy for Heterogeneous Breast Cancer

Self-assembly of DNA-gold nanoaggregate for visual detection of thymidine kinase 1 (TK1) mRNA via lateral flow assay

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