Self-assembled polymer particles based on thermoresponsive biodegradable copolymers of amino acids

Vdovchenko, Alena; Hubina, A.; Влах, Е. Г.; Tennikova, Tatiana

doi:10.1016/j.mencom.2017.03.015

Cited by 8 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The THF used as eluent for size exclusion chromatography (SEC) analysis was of HPLC grade and purchased from Merck (Darmstadt, Germany). PGlu was synthesized in IMC RAS via the ring-opening polymerization of γ-O-benzyl-α-glutamic acid N-carboxyanhydride, and then deprotected with TFA/TFSA, as described elsewhere [32,33]. The characteristics of PGlu were the following: M w = 2100 (weight average molecular weight), M n = 2000 (number average molecular weight), Ɖ = 1.05 (dispersity), and the amount of residual benzyl groups was 22% (according to NMR) [34].…”

Section: Methodsmentioning

confidence: 99%

PGlu-Modified Nanocrystalline Cellulose Improves Mechanical Properties, Biocompatibility, and Mineralization of Polyester-Based Composites

et al. 2019

View full text Add to dashboard Cite

The development of biocompatible composite materials is in high demand in many fields such as biomedicine, bioengineering, and biotechnology. In this study, two series of poly (D,L-lactide) and poly (ε-caprolactone)-based films filled with neat and modified with poly (glutamic acid) (PGlu) nanocrystalline cellulose (NCC) were prepared. An analysis of scanning electron and atomic force microscopies’ results shows that the modification of NCC with poly (glutamic acid) favored the better distribution of the nanofiller in the polymer matrix. Investigating the ability of the developed materials to attract and retain calcium ions led to the conclusion that composites containing NCC modified with PGlu induced better mineralization from model solutions than composites containing neat NCC. Moreover, compared to unmodified NCC, functionalization with PGlu improved the mechanical properties of composite films. The subcutaneous implantation of these composite materials into the backs of rats and the further histological investigation of neighboring tissues revealed the better biocompatibility of polyester materials filled with NCC–PGlu.

show abstract

Section: Methodsmentioning

confidence: 99%

PGlu-Modified Nanocrystalline Cellulose Improves Mechanical Properties, Biocompatibility, and Mineralization of Polyester-Based Composites

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In addition to copolymerization, modification of the side chains of homopolypeptides is also a widely used strategy to introduce new functionalities and produce copolypeptides. It can be the modification with other amino acids [71,72] or small functional moieties such as hydrophobic fragments [73,74], sugar units [75,76], OEG and pyridinium tetrafluoroborate [77], allyl or propargyl groups [78], etc.…”

Section: Copolypeptidesmentioning

confidence: 99%

Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery

Stepanova,

Nikiforov,

Tennikova

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition and architecture can vary over a wide range. Their unique ability to form secondary structures, as well as different pathways of modification and biofunctionalization due to the diversity of amino acids, provide variation in the physicochemical and biological properties of polypeptide-containing materials. In this review article, we summarize the advances in the synthesis of polypeptides and their copolymers and the application of these systems for drug delivery in the form of (nano)particles or hydrogels. The issues, such as the diversity of polypeptide-containing (nano)particle types, the methods for their preparation and drug loading, as well as the influence of physicochemical characteristics on stability, degradability, cellular uptake, cytotoxicity, hemolysis, and immunogenicity of polypeptide-containing nanoparticles and their drug formulations, are comprehensively discussed. Finally, recent advances in the development of certain drug nanoformulations for peptides, proteins, gene delivery, cancer therapy, and antimicrobial and anti-inflammatory systems are summarized.

show abstract

“…Accordingly, the temperature variation is a simple way to control the behavior of their solutions [ 1 , 2 , 3 , 4 , 5 , 6 ]. Thermoresponsive polymers are highly appealing for medical applications and biotechnology if the phase separation temperature is close to body temperature [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. Polymers used in biomedical applications must be non-toxic, biocompatible, stable in biological media, biodegradable, and/or completely excreted from the body.…”

Section: Introductionmentioning

confidence: 99%

Influence of Salt on the Self-Organization in Solutions of Star-Shaped Poly-2-alkyl-2-oxazoline and Poly-2-alkyl-2-oxazine on Heating

et al. 2021

View full text Add to dashboard Cite

The water–salt solutions of star-shaped six-arm poly-2-alkyl-2-oxazines and poly-2-alkyl-2-oxazolines were studied by light scattering and turbidimetry. The core was hexaaza[26]orthoparacyclophane and the arms were poly-2-ethyl-2-oxazine, poly-2-isopropyl-2-oxazine, poly-2-ethyl-2-oxazoline, and poly-2-isopropyl-2-oxazoline. NaCl and N-methylpyridinium p-toluenesulfonate were used as salts. Their concentration varied from 0–0.154 M. On heating, a phase transition was observed in all studied solutions. It was found that the effect of salt on the thermosensitivity of the investigated stars depends on the structure of the salt and polymer and on the salt content in the solution. The phase separation temperature decreased with an increase in the hydrophobicity of the polymers, which is caused by both a growth of the side radical size and an elongation of the monomer unit. For NaCl solutions, the phase separation temperature monotonically decreased with growth of salt concentration. In solutions with methylpyridinium p-toluenesulfonate, the dependence of the phase separation temperature on the salt concentration was non-monotonic with minimum at salt concentration corresponding to one salt molecule per one arm of a polymer star. Poly-2-alkyl-2-oxazine and poly-2-alkyl-2-oxazoline stars with a hexaaza[26]orthoparacyclophane core are more sensitive to the presence of salt in solution than the similar stars with a calix[n]arene branching center.

show abstract

Self-assembled polymer particles based on thermoresponsive biodegradable copolymers of amino acids

Cited by 8 publications

References 17 publications

PGlu-Modified Nanocrystalline Cellulose Improves Mechanical Properties, Biocompatibility, and Mineralization of Polyester-Based Composites

PGlu-Modified Nanocrystalline Cellulose Improves Mechanical Properties, Biocompatibility, and Mineralization of Polyester-Based Composites

Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery

Influence of Salt on the Self-Organization in Solutions of Star-Shaped Poly-2-alkyl-2-oxazoline and Poly-2-alkyl-2-oxazine on Heating

Contact Info

Product

Resources

About