Self-Assembled PHMB Titanium Coating Enables Anti-Fusobacterium nucleatum Strategy

Zhao, Jing; Jin, Shixin; Delgado, António H. S.; Chen, Zhuofan; Matinlinna, Jukka Pekka; Tsoi, James Kit‐Hon

doi:10.3390/coatings11101190

Cited by 6 publications

(5 citation statements)

References 41 publications

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“…To further improve the bactericidal effect, synthetic polymer coatings have been applied to drug-delivery systems. For example, poly(L-lactic acid) nanoparticle coatings [ 98 , 243 ] and layer-by-layer deposited poly(acrylic acid)-poly-L-lysine coatings [ 244 ], have been used to load and release numerous antibacterial agents, or directly as the antibacterial agents [ 137 ] to prevent peri-implant diseases. The explosive release of antibiotics in the initial stage may result in poor antibacterial effect in preventing bacterial invasion, leading to implantation failure.…”

Section: Strategies To Enhance Ti-based Implant Successmentioning

confidence: 99%

Biomaterials science and surface engineering strategies for dental peri-implantitis management

Yu,

Lu,

Zhang

et al. 2024

Military Med Res

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Peri-implantitis is a bacterial infection that causes soft tissue inflammatory lesions and alveolar bone resorption, ultimately resulting in implant failure. Dental implants for clinical use barely have antibacterial properties, and bacterial colonization and biofilm formation on the dental implants are major causes of peri-implantitis. Treatment strategies such as mechanical debridement and antibiotic therapy have been used to remove dental plaque. However, it is particularly important to prevent the occurrence of peri-implantitis rather than treatment. Therefore, the current research spot has focused on improving the antibacterial properties of dental implants, such as the construction of specific micro-nano surface texture, the introduction of diverse functional coatings, or the application of materials with intrinsic antibacterial properties. The aforementioned antibacterial surfaces can be incorporated with bioactive molecules, metallic nanoparticles, or other functional components to further enhance the osteogenic properties and accelerate the healing process. In this review, we summarize the recent developments in biomaterial science and the modification strategies applied to dental implants to inhibit biofilm formation and facilitate bone-implant integration. Furthermore, we summarized the obstacles existing in the process of laboratory research to reach the clinic products, and propose corresponding directions for future developments and research perspectives, so that to provide insights into the rational design and construction of dental implants with the aim to balance antibacterial efficacy, biological safety, and osteogenic property.

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Section: Strategies To Enhance Ti-based Implant Successmentioning

confidence: 99%

Biomaterials science and surface engineering strategies for dental peri-implantitis management

Yu,

Lu,

Zhang

et al. 2024

Military Med Res

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“…The Ti surface is covered with another material, which can change the composition of the implant surface to a greater extent and achieve more excellent biomedical functions. Coating technologies include plasma spraying, , nanospray drying, sol–gel method, , hydrothermal method, , self-assembly method, , 3D printing, and so on.…”

Section: Surface Modification Techniques For Dental Implantsmentioning

confidence: 99%

Surface Modification and Functionalities for Titanium Dental Implants

Sun,

Liu,

Wang

et al. 2023

ACS Biomater. Sci. Eng.

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Dental implants have become the mainstream strategy for oral restoration, and implant materials are the most important research hot spot in this field. So far, Ti implants dominate all kinds of implants. The surface properties of the Ti implant play decisive roles in osseointegration and antibacterial performance. Surface modifications can significantly change the surface micro/nanotopography and composition of Ti implants, which will effectively improve their hydrophilicity, mechanical properties, osseointegration performance, antibacterial performance, etc. These optimizations will thus improve implant success and service life. In this paper, the latest surface modification techniques of Ti dental implants are systematically and comprehensively reviewed. The various biomedical functionalities of surface modifications are discussed in-depth. Finally, a profound comment on the challenges and opportunities of this frontier is proposed, and the most promising directions for the future were explored.

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“…For in vitro assessments, polyhexanide (PHA) and polyhexamethylene biguanide (PHMB) are commonly employed for wound treatment as well as oral and ocular disinfection. [52,54] These agents exhibit promising outcomes in antimicrobial assays, effectively inhibiting F. nucleatum biofilms in vitro. More specifically, they have demonstrated a significant reduction in F. nucleatum survival relative to the control group, as confirmed by real-time PCR.…”

Section:  Polymersmentioning

confidence: 99%

“…[ 48‐51 ] The fourth part discusses the inhibitory effects of polymers against F. nucleatum and presents examples of using antibacterial polymers to suppress drug‐resistant CRC. [ 52–56 ] In the following section, inorganic‐organic hybrid materials for F. nucleatum killing will be presented. Some dual‐combination antibacterial strategies will open up new ideas for F. nucleatum inhibition.…”

Section: Introductionmentioning

confidence: 99%

Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

Liu,

Yu,

Dong

et al. 2023

Exploration

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Colorectal cancer (CRC) is generally characterized by a high prevalence of Fusobacterium nucleatum (F. nucleatum), a spindle‐shaped, Gram‐negative anaerobe pathogen derived from the oral cavity. This tumor‐resident microorganism has been closely correlated with the occurrence, progression, chemoresistance and immunosuppressive microenvironment of CRC. Furthermore, F. nucleatum can specifically colonize CRC tissues through adhesion on its surface, forming biofilms that are highly resistant to commonly used antibiotics. Accordingly, it is crucial to develop efficacious non‐antibiotic approaches to eradicate F. nucleatum and its biofilms for CRC treatment. In recent years, various antimicrobial strategies, such as natural extracts, inorganic chemicals, organic chemicals, polymers, inorganic‐organic hybrid materials, bacteriophages, probiotics, and vaccines, have been proposed to combat F. nucleatum and F. nucleatum biofilms. This review summarizes the latest advancements in anti‐F. nucleatum research, elucidates the antimicrobial mechanisms employed by these systems, and discusses the benefits and drawbacks of each antimicrobial technology. Additionally, this review also provides an outlook on the antimicrobial specificity, potential clinical implications, challenges, and future improvements of these antimicrobial strategies in the treatment of CRC.

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Self-Assembled PHMB Titanium Coating Enables Anti-Fusobacterium nucleatum Strategy

Cited by 6 publications

References 41 publications

Biomaterials science and surface engineering strategies for dental peri-implantitis management

Biomaterials science and surface engineering strategies for dental peri-implantitis management

Surface Modification and Functionalities for Titanium Dental Implants

Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

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