Self-Assembled pH-Sensitive Polymeric Nanoparticles for the Inflammation-Targeted Delivery of Cu/Zn-Superoxide Dismutase

Sun, Xiangshi; Zhou, Yanmin; Dong, Shiyan; Hu, Wenjing; Sun, Yating; Li, Yuhuan; Xie, Jing; Lee, Robert J.; Sun, Fengying; Ma, Yifan; Wang, Shengnian; Kim, Betty Y.S.; Wang, Yifan; Yang, Zhaogang; Jiang, Wen; Li, Youxin; Teng, Lesheng

doi:10.1021/acsami.1c03589

Cited by 21 publications

(15 citation statements)

References 44 publications

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“…The group of novel polymers was utilized for their self-assembly into micellar nanoparticles to impart desirable hydrolytic characteristics, prolonged circulation, biocompatibility, and inflammation targetability. The pharmacodynamic outcomes showed excellent antioxidant and anti-inflammatory activities in adjuvant arthritis and peritonitis models (Sun et al, 2021).…”

Section: Applications Of Self-assembled Nanoparticles Polymeric Nanop...mentioning

confidence: 97%

Current State-of-the-Art and New Trends in Self-Assembled Nanocarriers as Drug Delivery Systems

Paliwal

Parihar

Prajapati

2022

Front. Nanotechnol.

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Self-assembled nanocarrier drug delivery has received profuse attention in the field of diagnosis and treatment of diseases. These carriers have proved that serious life-threatening diseases can be eliminated evidently by virtue of their characteristic design and features. This review is aimed at systematically presenting the research and advances in the field of self-assembled nanocarriers such as polymeric nanoparticles, dendrimers, liposomes, inorganic nanocarriers, solid lipid nanoparticles, polymerosomes, micellar systems, niosomes, and some other nanoparticles. The self-assembled delivery of nanocarriers has been developed in recent years for targeting diseases. Some of the innovative attempts with regard to prolonging drug action, improving bioavailability, avoiding drug resistance, enhancing cellular uptake, and so on have been discussed. The discussion about various delivery systems included the investigation conducted at the preliminary stage, i.e., preclinical trials and assessment of safety. The clinical studies of some of the recently developed self-assembled products are currently at the clinical trial phase or FDA approved.

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Section: Applications Of Self-assembled Nanoparticles Polymeric Nanop...mentioning

confidence: 97%

Current State-of-the-Art and New Trends in Self-Assembled Nanocarriers as Drug Delivery Systems

Paliwal

Parihar

Prajapati

2022

Front. Nanotechnol.

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“…A small library of biocompatible amphiphilic polymers based on methoxy poly(ethylene glycol)-poly (cyclohexane-1,4-diyl acetone dimethyleneketal) and methoxy poly(ethylene glycol)-poly((cyclohexane 86.7% , 1,5-pentane-diol 13.3% )-1,4-diyl acetone dimethylene ketal) has been synthesized for the targeted delivery of superoxide dismutase. The novel polymers release the enzyme in a pH-dependent manner, thus allowing the enzyme, which is normally rapidly cleared or degraded in vivo, to show good anti-oxidant and anti-inflammatory activities in AIA rats [158].…”

Section: Ph-responsive Drug Deliverymentioning

confidence: 99%

Recent advances in nano-targeting drug delivery systems for rheumatoid arthritis treatment

Gou

Liao

et al. 2023

Acta Materia Medica

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Rheumatoid arthritis is a systemic inflammatory disease that can lead to articular cartilage destruction and periarticular bone erosion, thus ultimately compromising joint integrity and function. Anti-inflammatory drugs and biological agents are commonly used to treat rheumatoid arthritis, but they cannot selectively target inflamed joints, because of their systemic mechanisms, short half-lives and low bioavailability. Consequently, these agents must be used at high doses and delivered frequently, thereby increasing costs and the risk of adverse effects. Drug delivery systems, such as nanoparticles, liposomes and micelles, can significantly prolong drug half-life in the body and enable targeted delivery into the joints. In this review, we comprehensively describe the pathogenesis and clinical diagnosis of rheumatoid arthritis, and summarize recent advances in targeted therapeutic strategies, particularly nano-targeting systems for rheumatoid arthritis.

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“…Nanoparticles, nanoflowers, nanoenzyme, and other nano-scale materials have received considerable attention since they have high stability, durability, selectivity, a large surface-to-volume ratio, simple synthesis, and low-cost in a variety of biosensors (Lee et al, 2016;Durrani-Kolarik et al, 2017;Sun et al, 2018aSun et al, , 2021Tran and Kim, 2018;Wu et al, 2020). Furthermore, combining bioinspired materials with nanotechnologies that alter or modify the properties of nanomaterials can decrease background noise, increase targeting efficiency, and enhance the detected signal.…”

Section: Nanoparticlesmentioning

confidence: 99%

Biomimetic Nanostructure Platform for Cancer Diagnosis Based on Tumor Biomarkers

Rao

et al. 2021

Front. Bioeng. Biotechnol.

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Biomarker discovery and its clinical use have attracted considerable attention since early cancer diagnosis can significantly decrease mortality. Cancer biomarkers include a wide range of biomolecules, such as nucleic acids, proteins, metabolites, sugars, and cytogenetic substances present in human biofluids. Except for free-circulating biomarkers, tumor-extracellular vesicles (tEVs) and circulating tumor cells (CTCs) can serve as biomarkers for the diagnosis and prognosis of various cancers. Considering the potential of tumor biomarkers in clinical settings, several bioinspired detection systems based on nanotechnologies are in the spotlight for detection. However, tremendous challenges remain in detection because of massive contamination, unstable signal-to-noise ratios due to heterogeneity, nonspecific bindings, or a lack of efficient amplification. To date, many approaches are under development to improve the sensitivity and specificity of tumor biomarker isolation and detection. Particularly, the exploration of natural materials in biological frames has encouraged researchers to develop new bioinspired and biomimetic nanostructures, which can mimic the natural processes to facilitate biomarker capture and detection in clinical settings. These platforms have substantial influence in biomedical applications, owing to their capture ability, significant contrast increase, high sensitivity, and specificity. In this review, we first describe the potential of tumor biomarkers in a liquid biopsy and then provide an overview of the progress of biomimetic nanostructure platforms to isolate and detect tumor biomarkers, including in vitro and in vivo studies. Capture efficiency, scale, amplification, sensitivity, and specificity are the criteria that will be further discussed for evaluating the capability of platforms. Bioinspired and biomimetic systems appear to have a bright future to settle obstacles encountered in tumor biomarker detection, thus enhancing effective cancer diagnosis.

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Self-Assembled pH-Sensitive Polymeric Nanoparticles for the Inflammation-Targeted Delivery of Cu/Zn-Superoxide Dismutase

Cited by 21 publications

References 44 publications

Current State-of-the-Art and New Trends in Self-Assembled Nanocarriers as Drug Delivery Systems

Current State-of-the-Art and New Trends in Self-Assembled Nanocarriers as Drug Delivery Systems

Recent advances in nano-targeting drug delivery systems for rheumatoid arthritis treatment

Biomimetic Nanostructure Platform for Cancer Diagnosis Based on Tumor Biomarkers

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