Self-assembled oligonucleotide-polyester dendrimers

Abstract

A new approach to the controlled synthesis of multicomponent dendrimers is presented, in which three oligonucleotide-dendron conjugates were synthesized using solid phase techniques and hybridized to create a second generation polyester dendrimer with DNA as a core and bearing two types of peripheral functional groups.

Applications of Orthogonal “Click” Chemistries in the Synthesis of Functional Soft Materials

“…438,439 Similar strategies have been employed to synthesize peptides bearing initiators for controlled polymerization in solution via ATRP, 14,440–442 as well as RAFT. 443 Solid phase strategies have also been utilized for the preparation of conjugated polymer-peptide hybrids, 444 various PEG-peptide block copolymers, 445,446 dendrimer hybrids 89,447 among many other examples. 406,413 …”

A Synthetic “Tour de Force”: Well‐Defined Multivalent and Multimodal Dendritic Structures for Biomedical Applications

“…In contrast to the Upy dimerization, DNA hybridization is suitable for application in aqueous systems and can also be used to design asymmetric systems. In fact, it is not even limited to the connection of just two elements, as demonstrated by Fréchet and co‐workers for a three‐component system 27. Although the hybridization is only demonstrated with statistically modified dendrimers or unmodified dendrons in both cases, this approach undoubtedly also allows the linkage of well‐defined, discrete functionalized dendrons.…”

Ein Meisterstück in der Synthese: wohldefinierte, multivalente und multimodale dendritische Architekturen für biomedizinische Anwendungen

“…FrØchet und Mitarbeiter konnten zudem den Aufbau eines Dreikomponentensystems zeigen. [27] Obwohl die Hybridisierung in beiden Fällen lediglich mit statistisch modifizierten Dendrimeren oder unmodifizierten Dendrons gezeigt wurde, eignet sich dieser Ansatz sicher auch zur Verknüpfung von wohldefinierten, diskret funktionalisierten Dendrons. Schema 4.…”